Supplemental Figure 1. Chemical structures and rela ve binding affini es for ligands used. Rela ve binding affini es are for wild-âtype AR rela ve to R1881.
Supplemental Figure 1, Brooke et al. Androgens
Dihydrotestosterone (DHT)
Mibolerone (MIB)
RBA = 100 (24)
RBA = 100 (25)
Steroidal an/-‐androgen
Cyproterone Acetate (CPA) RBA = 2.2 (26)
Non-‐steroidal an/-‐androgen
Bicalutamide (BIC)
Hydroxyflutamide (OHF)
RBA = 6.36 (24)
RBA = 1 (24)
Supplemental Figure 1. Chemical structures and relaLve binding affiniLes for ligands used. RelaLve binding affiniLes are for wild-‐type AR relaLve to R1881.
