RESEARCH ARTICLE
Cancer-Related Causes of Death among HIVInfected Patients in France in 2010: Evolution since 2000 Marie-Anne Vandenhende1,2,3*, Caroline Roussillon1,2, Sandrine Henard4, Philippe Morlat1,2,3, Eric Oksenhendler5, Hugues Aumaitre6, Aurore Georget1,2, Thierry May4, Eric Rosenthal7,8, Dominique Salmon9,10, Patrice Cacoub11,12, Dominique Costagliola13,14, Geneviève Chêne1,2, Fabrice Bonnet1,2,3, the ANRS EN20 Mortalité 2010 study group¶
OPEN ACCESS Citation: Vandenhende M-A, Roussillon C, Henard S, Morlat P, Oksenhendler E, Aumaitre H, et al. (2015) Cancer-Related Causes of Death among HIVInfected Patients in France in 2010: Evolution since 2000. PLoS ONE 10(6): e0129550. doi:10.1371/ journal.pone.0129550 Academic Editor: Patrick S Sullivan, Rollins School of Public Health, Emory University, UNITED STATES
1 INSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistiques, Bordeaux, France, 2 Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistiques, Bordeaux, France, 3 Service de médecine interne et maladies infectieuses, CHU de Bordeaux, Bordeaux, France, 4 Service de Maladies Infectieuses, Hôpital Brabois, Vandoeuvre-Les-Nancy, France, 5 Service d’Immunopathologie Clinique, Hôpital Saint Louis, AP-HP, Paris, France, 6 Service des Maladies Infectieuses, Centre Hospitalier, Perpignan, France, 7 Service de Médecine Interne, Hôpital de l’Archet, Nice, France, 8 Université de NiceSophia Antipolis, Nice, France, 9 Unité de Pathologie Infectieuse, Pôle Médecine, Hôpital Cochin, AP-HP, Paris, France, 10 Université Paris Descartes, Paris, France, 11 Service de Médecine Interne, Hôpital La Pitié-Salpêtrière, AP-HP, Paris, France, 12 Université Pierre et Marie Curie, Paris, France, 13 INSERM, UMR_S 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Paris, France, 14 Sorbonne Universités, UPMC Université Paris 06, UMR_S 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Paris, France ¶ Membership of the ANRS EN20 Mortalité 2010 study group is listed in the Acknowledgments. *
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Abstract
Received: December 16, 2014 Accepted: May 10, 2015
Objectives
Published: June 17, 2015
The current study aimed at describing the distribution and characteristics of malignancy related deaths in human immunodeficiency virus (HIV) infected patients in 2010 and at comparing them to those obtained in 2000 and 2005.
Copyright: © 2015 Vandenhende et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper. Funding: This study was supported by the Agence Nationale de Recherche sur le Sida et les hépatites virales (ANRS)/French National Agency for Research on AIDS and Viral Hepatitis. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have read the journal's policy and the authors of this manuscript have the following competing interests: CR, AG, EO
Methods Data were obtained from three national surveys conducted in France in 2010, 2005 and 2000. The underlying cause of death was documented using a standardized questionnaire fulfilled in French hospital wards involved in the management of HIV infection.
Results Among the 728 deaths reported in 2010, 262 were cancer-related (36%). After a significant increase from 28% in 2000 to 33% in 2005 and 36% in 2010, cancers represent the leading cause of mortality in HIV infected patients. The proportion of deaths attributed to non-AIDS/ non-hepatitis-related cancers significantly increased from 2000 to 2010 (11% of the deaths in 2000, 17% in 2005 and 22% in 2010, p
