Journal of Chemotherapy
Vol. 23 - n. 2 (97-101) - 2011
REVIEW Comparative In Vitro Susceptibility of Clinical isolates of Candida parapsilosis Complex and Other Candida Species to Caspofungin and Anidulafungin by etest Z. KHAn - s. AHMAD - L. JOsEPH - R. CHAnDY - A. THEYYATHEL Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait Correspondence: Prof. Ziauddin Khan, Department of Microbiology, Faculty of Medicine, Kuwait University, P. O. Box 24923, safat, Kuwait-13110. Email:
[email protected]. Tel: 00965-24986504 ; Fax: 00965-25318454/25332719
Summary In vitro susceptibility of 141 clinical isolates of Candida species to caspofungin and anidulafungin is reported. the etest was performed according to recommended procedure and minimum inhibitory concentrations (miCs) were read after 24 h of incubation at 35oC. Applying a breakpoint of ≤2 mg/ml, all Candida spp. isolates, except those belonging to C. parapsilosis complex, were susceptible. the geometric mean for caspofungin and anidulafungin for different Candida spp. were as follows: Candida parapsilosis, 0.438 and 3.355 mg/ml; Candida orthopsilosis, 0.210 and 1.456 mg/ml; Candida albicans, 0.049 and 0.007 mg/ml; Candida dubliniensis, 0.077 and 0.009 mg/ml; Candida tropicalis, 0.061 and
0.027 mg/ml; Candida glabrata, 0.120 and 0.032 mg/ml; and Candida krusei, 0.288 and 0.052 mg/ml, respectively. Anidulafungin was significantly more active than caspofungin (p 2 mg/ml was similar between those originating from blood and other clinical specimens (Table 3). Only two isolates of C. orthopsilosis showed anidulafungin MiCs >2 mg/ml (Table 3). Excluding the isolates of C. parapsilosis species complex, the mean MiCs for caspofugin and anidulafungin for other Candida spp. were 0.090 and 0.017 mg/ml, respectively, indicating that the latter drug has significantly higher in vitro activity against other Candida species tested (p
