CAP2 vs. Control

HIST1H2BD ALDH8A1 HIST1H2AB /// HIST1H2AE TTC18 HIST1H2AG /// HIST1H2AH /// HIST1H2AI /// HIST1H2AK /// HIST1H2AL /// HIST1H2AM NCALD ERVK3-‐2 /// LOC100506358 NPR3 NOV CCL4 /// CCL4L1 /// CCL4L2 /// LOC101060278 SERPINC1 EGR1 HIST2H2BE HIST1H2BC /// HIST1H2BE /// HIST1H2BF /// HIST1H2BG /// HIST1H2BI /// NCALD SLC17A8 HIST2H2AA3 /// HIST2H2AA4 HIST1H1C SSR1 MDM2 HIST1H2BC /// HIST1H2BE /// HIST1H2BF /// HIST1H2BG /// HIST1H2BI OSGIN1 FBXO11 CDKL2 LTB4R GLS ADRBK2 CYP2C9 PLGLA /// PLGLB1 /// PLGLB2 GUCA1B T1H4B /// HIST1H4C /// HIST1H4D /// HIST1H4E /// HIST1H4F /// HIST1H4H /// HIST1H4I /// HIST1H4J /// HIST1H4K /// HIST1H4L /// HIST2H4A /// HIST2H4B /// HIST4H4 WDR96 LSMEM1 TNFSF13B TICAM2 /// TMED7-‐TICAM2 ARRDC4 ATF3 SRXN1 SCG5 TDRD6 CD200R1 ACTG1P4 /// AMY1A /// AMY1B /// AMY1C /// AMY2A /// AMY2B MSH4 SCARNA14 SOX30 ACTC1 PRDM2 CDKN1A MYRFL DHRS2 ITGAM ITGA9 RNF150 LRRC8C CHRNA10 HIST1H2BK HIST1H2BJ HIST1H2AC CORIN RASA4 /// RASA4B LAT2 LDHAL6B HIST1H3A /// HIST1H3B /// HIST1H3C /// HIST1H3D /// HIST1H3E /// HIST1H3F /// HIST1H3G /// HIST1H3H /// HIST1H3I /// HIST1H3J PLAGL1 MBP ALLC BTG2 CCDC11 ZNF211 PYGM RHOB SERTAD1 NFYA ERRFI1 TXK SRP19 /// ZRSR1 KIAA1683 TLL2 CLEC4A C12orf5 MGEA5 SCARNA20 PDZK1 /// PDZK1P1 LOC101060503 /// TXNIP MIR22 /// MIR22HG CHST7 LOC100507577 /// LONP2 POPDC2 C18orf25 MOBP SERPINE1 CREBRF TP53INP1 STX16 ACTG1P4 /// AMY2A /// AMY2B HIST1H2AK LRRC39 DNHD1 FOXD4 /// FOXD4L1 /// FOXD4L3 /// FOXD4L6 /// LOC101060560 CRYGS CDKN2D SECISBP2 ZNF791 TGOLN2 DCAF4L1 OSBPL8 KLF6 TARDBP LEFTY1 HIPK1

CAP2 vs. Control

UP 52 29 27 25 24 23 23 22 21 20 19 19 18 18 15 15 14 14 13 13 13 12 12 12 12 11 11 11 11 11 10 10 10 10 10 10 10 10 9 9 9 9 9 9 9 9 9 8 8 8 8 8 8 8 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5

DOWN SYNCRIP NMI ZMYND8 SLC16A14 VAV3 RFXAP KIT SRSF1 SPC25 PPIL1 ARMCX5 PTPRO ELK3 PCK1 SH3PXD2A CXCL3 FAIM KLHL23 /// PHOSPHO2-‐KLHL23 GJA1 DCAF16 GCNT3 ITPRIPL2 ADORA2B MLKL HNF4G PLEKHA2 STEAP1 TRAF5 SORBS2 LGR5 POLE2 PRMT6 KBTBD11 PPP1R9A PDGFC QSER1 FUT3 ZBTB38 MYB MAGEF1 AIM1 KIAA0226L RABGAP1L UTRN DIXDC1 SCAMP1 EFNA4 IL33 ZNF165 TM4SF1 PTGDR SPIN4 SMARCAD1 TRMT11 SP100 PHLDA1 SLITRK6 POLR3G CXCL1 IRF2BP2 ANKRD22 N4BP2L2 KCNN4 PAIP1 TUBBP5 ZCCHC10 LGALS8 CASD1 EMG1 C2CD2 USP46 TRABD2A WDFY3 CMPK2 STEAP2 RIMBP2 ACBD5 CXCL2 WT1 KIAA1430 INTS6 EREG SH3BP2 VPS54 AGR3 SLC35G1 CLASP2 DMRTA2 CDX1 UNC50 MYC TSEN2 UPRT PRR15L KLHL13 FAM169A ZNF827 E2F8 ZNF532 ELOVL6 TNFSF10 SSTR1 UHRF1BP1 RTN4IP1 LXN FUNDC1 DENND2D ZHX2 DLG3 STEAP1 /// STEAP1B

-‐34.0 -‐32.3 -‐28.5 -‐27.8 -‐27.2 -‐24.8 -‐23.8 -‐21.5 -‐21.1 -‐20.7 -‐20.0 -‐19.3 -‐18.6 -‐18.1 -‐18.0 -‐17.9 -‐17.9 -‐17.8 -‐17.3 -‐17.2 -‐16.9 -‐16.3 -‐16.2 -‐15.7 -‐15.5 -‐15.5 -‐15.5 -‐15.3 -‐15.2 -‐15.1 -‐15.1 -‐14.3 -‐14.3 -‐14.2 -‐14.1 -‐14.0 -‐13.9 -‐13.8 -‐13.6 -‐13.6 -‐13.5 -‐13.5 -‐13.0 -‐13.0 -‐13.0 -‐12.8 -‐12.8 -‐12.7 -‐12.5 -‐12.5 -‐12.4 -‐12.2 -‐12.1 -‐12.0 -‐11.8 -‐11.7 -‐11.7 -‐11.6 -‐11.5 -‐11.5 -‐11.4 -‐11.4 -‐11.3 -‐11.3 -‐11.3 -‐11.3 -‐11.3 -‐11.3 -‐11.2 -‐11.2 -‐11.1 -‐11.1 -‐11.0 -‐10.9 -‐10.9 -‐10.9 -‐10.9 -‐10.8 -‐10.7 -‐10.6 -‐10.6 -‐10.6 -‐10.5 -‐10.4 -‐10.4 -‐10.3 -‐10.3 -‐10.2 -‐10.2 -‐10.2 -‐10.2 -‐10.2 -‐10.1 -‐10.1 -‐10.1 -‐10.1 -‐9.9 -‐9.9 -‐9.9 -‐9.9 -‐9.9 -‐9.8 -‐9.8 -‐9.8 -‐9.8 -‐9.7 -‐9.7 -‐9.7 -‐9.7 -‐9.7

NFIA PSMG4 ADSS NSMCE4A DEPDC1 MYADM TGIF2 NDC1 EPHX4 SLC9A2 CRLS1 SLC38A1 LGALSL KCTD20 MTPAP CFL2 METAP2 MSH2 CAPRIN1 TACC2 MAP3K5 AGPS GPATCH2 SQLE METTL21A ASCL2 FASTKD2 RAD51AP1 PBDC1 C4orf19 TMEM68 PRKD3 ERBB2IP USP24 TRIM2 SRSF7 RNF125 UTP18 C2CD4A SCLT1 FUBP1 FNBP1L PRKCH TJP2 ZNF518A SNTB1 NUDT12 TRMT61B NAV2 TOX MET RANBP2 BRWD1 KIN IPO8 MDFIC MIR17 /// MIR17HG /// MIR18A /// MIR19A /// MIR19B1 /// MIR20A /// MIR92A1 MANSC1 PLA2G3 SRSF3 LNX1 C8orf44-‐SGK3 /// SGK3 GTF2H2 /// GTF2H2B /// GTF2H2C /// GTF2H2D DNAH14 ZDHHC23 FGFBP1 ARHGAP32 STAMBPL1 MOB1B CAND1 AGO4 LOC100190940 ABHD13 CD58 OR51E1 ARMC8 DTWD1 RRM2 NCAPG UBE2J1 LHFPL2 BIVM MTHFS /// ST20-‐MTHFS C19orf12 ATP2B1 ZC3HAV1L C8orf4 METTL8 SREK1IP1 FAM105A STXBP6 GTF2IRD1 CDC14B PLA2G4A MYCL1 OVOL2 ZNF681 PLSCR1 SLC43A3 EED NHLRC3 BAG2 NAA15 GIMAP2 UBE2Q2 XRCC4 ID4 RPS6KB1 SASS6 DDX52 RBM12 MRPL15 IFIH1 BUB1B PLEKHA5

-‐9.6 -‐9.5 -‐9.5 -‐9.5 -‐9.5 -‐9.4 -‐9.4 -‐9.4 -‐9.3 -‐9.3 -‐9.3 -‐9.2 -‐9.2 -‐9.2 -‐9.2 -‐9.2 -‐9.2 -‐9.2 -‐9.2 -‐9.2 -‐9.2 -‐9.2 -‐9.1 -‐9.1 -‐9.1 -‐9.1 -‐9.0 -‐9.0 -‐9.0 -‐9.0 -‐9.0 -‐8.9 -‐8.8 -‐8.8 -‐8.8 -‐8.8 -‐8.7 -‐8.7 -‐8.7 -‐8.7 -‐8.7 -‐8.6 -‐8.6 -‐8.6 -‐8.6 -‐8.5 -‐8.5 -‐8.5 -‐8.5 -‐8.5 -‐8.5 -‐8.5 -‐8.5 -‐8.5 -‐8.4 -‐8.4 -‐8.3 -‐8.3 -‐8.3 -‐8.3 -‐8.3 -‐8.3 -‐8.2 -‐8.2 -‐8.2 -‐8.2 -‐8.2 -‐8.2 -‐8.1 -‐8.1 -‐8.1 -‐8.1 -‐8.0 -‐8.0 -‐8.0 -‐8.0 -‐8.0 -‐8.0 -‐8.0 -‐8.0 -‐8.0 -‐8.0 -‐8.0 -‐8.0 -‐7.8 -‐7.8 -‐7.8 -‐7.8 -‐7.8 -‐7.8 -‐7.7 -‐7.7 -‐7.7 -‐7.7 -‐7.7 -‐7.6 -‐7.6 -‐7.5 -‐7.5 -‐7.5 -‐7.5 -‐7.5 -‐7.5 -‐7.5 -‐7.5 -‐7.5 -‐7.5 -‐7.5 -‐7.4 -‐7.4 -‐7.4 -‐7.4 -‐7.4 -‐7.4 -‐7.4

MYO1B BCL11B TCEAL8 LARP7 BRCA1 TMPO CKAP4 CHML TOMM40L NAPEPLD WDR36 KIF11 PHF2 GPR126 SKIV2L2 HIVEP1 ZFHX3 MMACHC FAM13A ANGEL2 MACC1 TCEAL1 EVA1A PTPRB EXOG SMAD6 CASP1 NAMPT GPR180 XKRX SEH1L RAP2C PSMG1 ZMYM2 KCTD14 /// NDUFC2-‐KCTD14 IQGAP2 PEX3 USP13 TET3 TIFA SPIN2A /// SPIN2B SLC4A7 THUMPD2 HNRNPDL MKI67 MT4 GTPBP8 ESRP1 IL20RA TMEM216 CEBPD ZNF689 PTGS2 KRIT1 PCDHB2 PNN DCLRE1A RAB28 PPP6C OPA1 CAV2 ADAT2 PARP9 HNRNPU TTF2 SIMC1 BCL2 GINS3 PSME4 EEF1E1 MBTPS2 PRLR ZNF260 SP8 FUT4 TLK1 ZNF639 CFLAR C15orf52 DSC2 ZNF248 HUNK C9orf64 PWP1 OAS1 PATZ1 CSTF3 FDXACB1 CELF2 PTPN3 LIPG CLDN1 KIAA1199 DEPTOR HMGA2 PPP2R1B ABHD12B /// MIR4454 MAGOHB SLC25A43 ITGB8 CRADD TMEM30B RPS14 ZBED1 TMEM168 RWDD3 /// TMEM56-‐RWDD3 ZNF618 PHACTR2 BUB3 IGF2BP3 AKAP1 ATP1B1 ANKRD13C QTRTD1 MAML3

-‐7.4 -‐7.4 -‐7.3 -‐7.3 -‐7.3 -‐7.3 -‐7.3 -‐7.3 -‐7.3 -‐7.3 -‐7.3 -‐7.3 -‐7.2 -‐7.2 -‐7.2 -‐7.2 -‐7.2 -‐7.2 -‐7.1 -‐7.1 -‐7.1 -‐7.1 -‐7.1 -‐7.1 -‐7.1 -‐7.1 -‐7.1 -‐7.1 -‐7.1 -‐7.0 -‐7.0 -‐7.0 -‐7.0 -‐7.0 -‐7.0 -‐7.0 -‐7.0 -‐7.0 -‐6.9 -‐6.9 -‐6.9 -‐6.9 -‐6.9 -‐6.9 -‐6.9 -‐6.8 -‐6.8 -‐6.8 -‐6.8 -‐6.8 -‐6.8 -‐6.8 -‐6.8 -‐6.8 -‐6.7 -‐6.7 -‐6.7 -‐6.7 -‐6.7 -‐6.7 -‐6.7 -‐6.7 -‐6.7 -‐6.7 -‐6.6 -‐6.6 -‐6.6 -‐6.6 -‐6.6 -‐6.6 -‐6.6 -‐6.6 -‐6.6 -‐6.6 -‐6.6 -‐6.5 -‐6.5 -‐6.5 -‐6.5 -‐6.4 -‐6.4 -‐6.4 -‐6.4 -‐6.4 -‐6.4 -‐6.4 -‐6.4 -‐6.4 -‐6.4 -‐6.4 -‐6.4 -‐6.3 -‐6.3 -‐6.3 -‐6.3 -‐6.3 -‐6.3 -‐6.3 -‐6.3 -‐6.3 -‐6.3 -‐6.3 -‐6.3 -‐6.3 -‐6.3 -‐6.3 -‐6.3 -‐6.2 -‐6.2 -‐6.2 -‐6.2 -‐6.2 -‐6.2 -‐6.2 -‐6.2

VEZT ERICH1 GHR ITGA6 GLRX SMARCAL1 UCHL5 PTGER4 TMEM246 SHANK2 SLC17A5 METTL1 GPR39 LOC100509484 /// PLIN2 PDS5B KLHL7 TMEM56 TNS3 NUP35 FUT2 SNX9 NASP TCERG1 PCGF6 ENPP4 DENND4C ZNF711 SENP7 KNSTRN CFTR PDE5A NUDCD1 PRDM8 CLPX RPAIN XK CD24 INPP1 C9orf40 VASH2 IRS1 GJB2 ATP7B PRDM16 ZNF32 NIF3L1 NF1 LYSMD2 KLHL42 ZMYM6 /// ZMYM6NB ZNF189 ELF2 NFIC MND1 E2F5 PARP2 MTMR1 MPZL2 MCPH1 HEATR1 TBL1XR1 SETD6 ZNF232 RQCD1 FYCO1 CCDC58 TRIM32 MDGA2 C1orf106 PLCB4 RFC3 MKX IVNS1ABP CAMK2N1 ZBED6CL SBF2 TAF5L THRA LEPROTL1 SMIM3 AP4M1 SEMA3A CHRAC1 ASXL1 SRSF8 TMEM117 BEND3 TLR3 PCDHB14 IL8 TRAPPC13 FNDC3A ID2 EEPD1 KIAA1586 SLC11A2 SLTM BET1 LDOC1L HOMER1 LTV1 NR2C1 CDC7 MCM3 TAMM41 RAB27A PPM1A NUP98 DTX3L IRAK1BP1 IMPACT DDX60 MON2 KIAA0391 YAP1

-‐6.2 -‐6.1 -‐6.1 -‐6.1 -‐6.1 -‐6.1 -‐6.1 -‐6.1 -‐6.1 -‐6.1 -‐6.1 -‐6.1 -‐6.1 -‐6.1 -‐6.1 -‐6.0 -‐6.0 -‐6.0 -‐6.0 -‐6.0 -‐6.0 -‐6.0 -‐6.0 -‐6.0 -‐6.0 -‐6.0 -‐6.0 -‐6.0 -‐6.0 -‐6.0 -‐5.9 -‐5.9 -‐5.9 -‐5.9 -‐5.9 -‐5.9 -‐5.9 -‐5.9 -‐5.9 -‐5.9 -‐5.9 -‐5.9 -‐5.9 -‐5.8 -‐5.8 -‐5.8 -‐5.8 -‐5.8 -‐5.8 -‐5.8 -‐5.8 -‐5.8 -‐5.8 -‐5.8 -‐5.7 -‐5.7 -‐5.7 -‐5.7 -‐5.7 -‐5.7 -‐5.7 -‐5.7 -‐5.7 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.6 -‐5.5 -‐5.5 -‐5.5 -‐5.5 -‐5.5 -‐5.5 -‐5.5 -‐5.5 -‐5.5 -‐5.5 -‐5.5 -‐5.4 -‐5.4 -‐5.4 -‐5.4 -‐5.4 -‐5.4 -‐5.4 -‐5.4 -‐5.4 -‐5.4 -‐5.4 -‐5.4 -‐5.4 -‐5.4 -‐5.4 -‐5.4 -‐5.3 -‐5.3 -‐5.3 -‐5.3 -‐5.3 -‐5.3

ERLEC1 GGA2 ISCA1 ARID2 GNAI1 CTPS2 TBC1D9 ZW10 TOX3 ZFYVE16 SLC37A1 MRPS31 SMPDL3A GPRC5A COX20 TRAK2 AJUBA BBX RNF2 PIK3AP1 PVRL3 TM7SF3 SUV420H1 POLA2 SH3RF3 TBC1D8B HNRNPD TMEM39A SAP30 DENND5B DIMT1 RNF145 CSRP2BP /// PET117 NUP88 SH3RF2 NEDD4 RPGR XIAP STAU2 TRIB2 YARS2 NFKB1 IFT81 TIPIN RIF1 ICK DOCK9 IFT74 FAR2 ANKRD32 RNF138 AKAP2 /// PALM2-‐AKAP2 RNF144A SRP19 RAB11FIP2 PPP4R1 ROCK2 ZNF641 LYPLAL1 SENP6 TMEM218 UNC93A LURAP1L UTP20 KIF21A QRSL1 MYEOV GNPTAB IBTK LPPR1 AGFG1 PRKAA1 ZNF321P /// ZNF816 /// ZNF816-‐ZNF321P ZNF608 CCDC50 SNX13

-‐5.3 -‐5.3 -‐5.3 -‐5.3 -‐5.3 -‐5.3 -‐5.3 -‐5.3 -‐5.3 -‐5.3 -‐5.3 -‐5.3 -‐5.3 -‐5.3 -‐5.3 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.2 -‐5.1 -‐5.1 -‐5.1 -‐5.1 -‐5.1 -‐5.1 -‐5.1 -‐5.1 -‐5.1 -‐5.1 -‐5.1 -‐5.1 -‐5.1 -‐5.1 -‐5.1 -‐5.1 -‐5.0 -‐5.0 -‐5.0 -‐5.0 -‐5.0 -‐5.0 -‐5.0 -‐5.0 -‐5.0 -‐5.0 -‐5.0 -‐5.0 -‐5.0 -‐5.0

Ivermectin vs. Control UP CASP5 RAB39B ATF3 DDIT3 BEX2 ISG20 IFIT1 OASL IRF9 PEAR1 IL1A CDKN2B EGR1 FILIP1L GADD45A TSLP C8orf4 H1F0 IFIT2 ANXA1 IFI44 FAM129A VIMP SLC22A15 ZFAND2A HKDC1 WIPI1 ZNF222 SPINK1 CLGN AREG /// AREGB FBXO16 XDH C6orf223 HSPA13 FGF21 GDF15 SERPINB8 MIR22 /// MIR22HG ARMCX3 GTPBP2 NFIL3 CREB5 PECR PTPRH ZCCHC2 LRRC2 TRIB3 SEPP1 INHBE MYH4 SLC30A1 DAPP1 CREB5 /// LOC401317 LAMP3 SELM DNAJB9 CALCA ARHGAP29 FOS TMEM39A SQSTM1 LYPD6B FKBP14 IRF7 GK CHD2 /// LOC100507217 TMEM154 GADD45G RWDD2A CYP39A1

37.8 28.1 24.9 24.8 24.5 21.4 18.5 16.7 16.6 16.4 15.9 12.4 11.1 10.6 10.2 9.8 9.3 9.3 8.9 8.9 8.6 8.6 8.4 8.0 7.9 7.9 7.7 7.6 7.6 7.4 7.3 7.2 6.8 6.8 6.8 6.4 6.3 6.3 6.3 6.3 6.2 6.2 6.0 6.0 5.9 5.9 5.8 5.8 5.8 5.8 5.7 5.7 5.7 5.6 5.5 5.4 5.4 5.4 5.3 5.2 5.2 5.1 5.1 5.1 5.1 5.1 5.1 5.1 5.0 5.0 5.0

DOWN MT4 CXCL5 FGFBP1 UGT2B15 HMGB3 PTGDR PTPRO OLFM4 SMAD6 C10orf99 OR51E1 ID1 INSIG1 EPHB3 ID4 PLA2G3 CYB5B CCNE2 MIR636 /// SRSF2 FAM198B SLC39A10 FABP1 /// PRDM10 KIAA0101 SMOC2 H3F3A /// H3F3B /// MIR4738 CCNE1 LGR5 MCM3 HMGB1 HNRNPU ADRA2A ETS2 C2CD4A ISX ATP5G3 SRSF11 DEFA6 HSPA1A /// HSPA1B PDZD2 MYBL1 ID2 RASL11A GINS2 MYB FAM111B METTL7A CYTIP LYZ

-‐24.6 -‐21.5 -‐16.1 -‐16.0 -‐15.5 -‐15.1 -‐14.1 -‐13.4 -‐10.8 -‐10.3 -‐9.4 -‐8.6 -‐8.4 -‐8.4 -‐8.3 -‐8.1 -‐7.6 -‐7.0 -‐6.8 -‐6.7 -‐6.5 -‐6.5 -‐6.4 -‐6.3 -‐6.1 -‐6.0 -‐6.0 -‐6.0 -‐5.9 -‐5.9 -‐5.6 -‐5.6 -‐5.5 -‐5.4 -‐5.4 -‐5.3 -‐5.3 -‐5.3 -‐5.3 -‐5.2 -‐5.2 -‐5.1 -‐5.1 -‐5.1 -‐5.0 -‐5.0 -‐5.0 -‐5.0