Cell Cycle Arrest and Inhibition of Tumor Cell ... - Cancer Research

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Aug 1, 1995 - SDS-PAGE analysis each lane was loaded with cell lysates equivalent lo ..... T., Miura, K., Wu, D. J., Lois, A., and Carson, D. A. Deletions of the.
[CANCER RESEARCH 55, 3250-3253,

August 1, 1995]

Advances in Brief

Cell Cycle Arrest and Inhibition of Tumor Cell Proliferation by the pl6WK4 Gene Mediated by an Adenovirus Vector1 Xiaomei Jin, Dao Nguyen, Wei-Wei Zhang,2 Athanassios P. Kyritsis, and Jack A. Roth3 Section of Thoracic Molecular Oncology, Departments of Thoracic and Cardiovascular

Surgen- ¡X.J., D. N.. W-W. Z J. A. /?./, Neuro-Oncology

¡A.P. K.I. and Tumor Biology

[J. A. R.I. The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030

the suppressive function of the p/6INK4 gene and its potential in cancer gene therapy, we inserted the /?/6INK4 gene in a recombinant

Abstract The p/