RESEARCH ARTICLE
Central Pressure Appraisal: Clinical Validation of a Subject-Specific Mathematical Model Francesco Tosello1☯, Andrea Guala2☯, Dario Leone1, Carlo Camporeale2, Giulia Bruno1, Luca Ridolfi2, Franco Veglio1, Alberto Milan1* 1 Department of Medical Sciences, Division of Internal Medicine, Hypertension Unit, University Hospital ‘AOU Città della Salute e della Scienza di Torino', University of Torino, Torino, Italy, 2 DIATI, Politecnico di Torino, Turin, Italy ☯ These authors contributed equally to this work. *
[email protected]
a11111
Abstract Introduction OPEN ACCESS Citation: Tosello F, Guala A, Leone D, Camporeale C, Bruno G, Ridolfi L, et al. (2016) Central Pressure Appraisal: Clinical Validation of a Subject-Specific Mathematical Model. PLoS ONE 11(3): e0151523. doi:10.1371/journal.pone.0151523 Editor: Yoshihiro Fukumoto, Kurume University School of Medicine, JAPAN
Current evidence suggests that aortic blood pressure has a superior prognostic value with respect to brachial pressure for cardiovascular events, but direct measurement is not feasible in daily clinical practice.
Aim The aim of the present study is the clinical validation of a multiscale mathematical model for non-invasive appraisal of central blood pressure from subject-specific characteristics.
Received: October 18, 2015
Methods
Accepted: February 28, 2016
A total of 51 young male were selected for the present study. Aortic systolic and diastolic pressure were estimated with a mathematical model and were compared to the most-used non-invasive validated technique (SphygmoCor device, AtCor Medical, Australia). SphygmoCor was calibrated through diastolic and systolic brachial pressure obtained with a sphygmomanometer, while model inputs consist of brachial pressure, height, weight, age, left-ventricular end-systolic and end-diastolic volumes, and data from a pulse wave velocity study.
Published: March 24, 2016 Copyright: © 2016 Tosello et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information file. Additional information can be requested by sending requests to
[email protected]. Funding: This work was supported by Ministry of Health (Italy) (Ricerca Sanitaria Finalizzata 2013 GR-2013-02356887). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist.
Results Model-estimated systolic and diastolic central blood pressures resulted to be significantly related to SphygmoCor-assessed central systolic (r = 0.65 p
