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Treatment for paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) and comorbid depression: a systematic review Maria E Loades,1 Elizabeth A Sheils,1 Esther Crawley2
To cite: Loades ME, Sheils EA, Crawley E. Treatment for paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) and comorbid depression: a systematic review. BMJ Open 2016;6: e012271. doi:10.1136/ bmjopen-2016-012271 ▸ Prepublication history and additional material is available. To view please visit the journal (http://dx.doi.org/ 10.1136/bmjopen-2016012271).
Received 13 April 2016 Revised 27 July 2016 Accepted 28 July 2016
1
Department of Psychology, University of Bath, Bath, UK 2 School of Social and Community Medicine, University of Bristol, Bristol, UK Correspondence to Dr Maria E Loades; m.e.
[email protected]
ABSTRACT Objectives: At least 30% of young people with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) also have symptoms of depression. This systematic review aimed to establish which treatment approaches for depression are effective and whether comorbid depression mediates outcome. Setting: A systematic review was undertaken. The search terms were entered into MEDLINE, EMBASE, PsycInfo and the Cochrane library. Participants: Inclusion and exclusion criteria were applied to identify relevant papers. Inclusion criteria were children age
