Eur Radiol (2016) 26:311–321 DOI 10.1007/s00330-015-3860-7
ONCOLOGY
Change in volume parameters induced by neoadjuvant chemotherapy provide accurate prediction of overall survival after resection in patients with oesophageal cancer Dietmar Tamandl 1 & Richard M. Gore 2 & Barbara Fueger 1 & Patrick Kinsperger 1 & Michael Hejna 4 & Matthias Paireder 3 & Alexander Haug 1 & Sebastian F. Schoppmann 3 & Ahmed Ba-Ssalamah 1
Received: 24 March 2015 / Revised: 4 May 2015 / Accepted: 20 May 2015 / Published online: 5 June 2015 # European Society of Radiology 2015
Abstract Objectives To assess the prognostic value of volumetric parameters measured with CT and PET/CT in patients with neoadjuvant chemotherapy (NACT) and resection for oesophageal cancer (EC). Methods Patients with locally advanced EC, who were treated with NACT and resection, were retrospectively analysed. Data from CT volumetry and 18 F-FDG PET/CT (maximum standardized uptake [SUVmax], metabolic tumour volume [MTV], and total lesion glycolysis [TLG]) were recorded before and after NACT. The impact of volumetric parameter changes induced by NACT (MTVRATIO, TLGRATIO, etc.) on overall survival (OS) was assessed using a Cox proportional hazards model. Results Eighty-four patients were assessed using CT volumetry; of those, 50 also had PET/CT before and after Electronic supplementary material The online version of this article (doi:10.1007/s00330-015-3860-7) contains supplementary material, which is available to authorized users. * Dietmar Tamandl
[email protected] 1
Department of Biomedical Imaging and Image-Guided Therapy, Comprehensive Cancer Center GET-Unit, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria
2
Department of Radiology, University of Chicago Pritzker School of Medicine, Chicago, IL, USA
3
Department of Surgery, Upper-GI-Service, Comprehensive Cancer Center GET-Unit, Medical University of Vienna, Vienna, Austria
4
Department of Internal Medicine, Division of Medical Oncology, Comprehensive Cancer Center GET-Unit, Medical University of Vienna, Vienna, Austria
NACT. Low post-treatment CT volume and thickness, MTV, TLG, and SUVmax were all associated with longer OS (p
