Chapter 3 Changes in microparticle numbers and ...

Downloaded from UvA-DARE, the Institutional Repository of the University of Amsterdam (UvA) http://dare.uva.nl/document/107883

Description File ID Filename

Chapter 3: Changes in microparticle numbers and cellular origin during pregnancy and preeclampsia 107883 06.pdf

SOURCE, OR PART OF THE FOLLOWING SOURCE: Type Dissertation Title Microparticles in pregnancy and preeclampsia Author C.A.R. Lok Faculty Faculty of Medicine Year 2008 Pages 216

FULL BIBLIOGRAPHIC DETAILS: http://dare.uva.nl/record/274059

Copyrights It is not permitted to download or to forward/distribute the text or part of it without the consent of the copyright holder (usually the author), other then for strictly personal, individual use.

UvA-DARE is a service provided by the Library of the University of Amsterdam (http://dare.uva.nl)



    

               

                           





!"# 



  &"&  ' (  ")&  &    *+  &  , &  &&+  !   * "!"!- &    &  ++  & &  !+.+. &* ++-/!* !   !   "+ * "& +"      *+ "& +"& " * & !  )"     . &!  &&   +.  "&-  "& +"  &  0 + !  -    !! ! +.    !  - * "& +"  +" .*+"+"& +"&" "&-""+  .-* &-+-   1"&-  &2% ! ""+  "& +"  +.&%3#$ '.! "4556( &-)    "& +"%3'"45557( #%'"455%(  #$   '"4552(    -!&-)    %3   '"4556(  &)   &"&-"& +""&-&  " . " &)    - & .  " '45##  "45528(  !& *    1 "&-  +. *   - &  .9 - + :  &)   &  ". - .& * " &  !  "& +"  & +. *      & "   & & +.*+&-)  * &+&-&  !&!+-.;" *!-+&* ++"& +"& *& .+.*   -*"& +"! +. ;" !"

& **&* 

 $%

&"& "&-"& +"



 !"  + "& ++. &  !&!.*+!& *&    ! &&   ""  &  * .  &   !   &  &"&  ' ( " -  *    .! * ++  & 2 % & +  "&-     +  "& +"  .! &!&: .- &  * &  "!-     * ++- #  &!  &&  +.!&  *&+- !& * !"&   -   ! ! ! +55A)&(+"  -:*+* && + &   '=  .( !  D * '& 1& B   (!*&'=(&'( !+&



$8

#

!"# 

 *.*!:-'="&  -(  ! &"&-  . ; E ; E ++  && * * && .  ! & )"&*& +&   .  && * & &&*-")+&!& ./!+.* "  " +& & !* *+ @+.?4;'255?8(;'>88?* (; '25$?%85( !&!!+.* !" *.!;E & )"&*&.- 255'P(!' (  +*! "*   *+ !&! 8 'P(   * .   >88 'P(  !    + * ! .   " *    *   !  + 'P(  -: " + .- ! * &-+  + "  .- 25$ '*+ P  (  * -  %85 'P(  !  

 +*!" + 9*+!&!   = &-+& -*" &)  "*+& "& '8P 9(&.*28+++"   *   + * 88 P *  & %8 ++ ?  % '?  " 76(   .  ,13%% * &.    ! ! %55 P * ? .9 -  C '=.(%)=/ '8 P(   * 28 +  + +"   . +.-*#55P.**+.+ &+". *+ +.*      1 -:!& & *!& &&**0    228 '  ; E  C&!+  /! ! ( 1**& . +"!& -:! )0!-F1&!+ .  &+"!!)9="I8 =!J;&+; + 'GE*"++!&&*+  (   -:  +.   *& *    '" ++( 1**&.!+ ""!"& +"&"* !**+" " -:! )0!-F'&)&  ++( * + !  +"     .  *  "& +"& " *  & "  ! +  & &    * !  -     -:!. )1**&&*& *"I558

 $$

&"& "&-"& +"



#"$ &     &!&&  ++:   * /! +   ! +  " +  #53 - &+"  %$8 -  ! "& +"& "  ;"&  .! - &   & .  "      ! "& +" &+"+ "&- !! !**&. " - " *2%  *!"!-" .*%5  /!+8'75)225( 83'85)75(  253'255)2%5( $3'88)78(  % $ ) %8%'257)653(

%$8'%53)##5(  2%5'225)288( 78'$8)>5(  2$5'265)%25( 228'>5)2#5(  25 2 >#'57)2$#( %5$'6%)8$3(

55#  55552 5552  55552 55552

 ' ?+%(

%#3'23%)#2>(

%2$'%55)653(



 #>#'#76)6%5( 2 7 #685'%>65)#375(

 #6#'%$2)#$$( 3 # 2#88'675)%#25(

1  - C' ( & E .! !!'+(

&

555$ ) 55#

55552 55# 55552

                                !     "#$   

  % &'     ( $      )    

*+,         



$7

#

!"# 

=+!+ ""& +"&"!*+ "&- .*!""&-G+!+ " "*"& +/+ "+ "& +"& " +   ! " "&-  - . K25>?  "4556( &+"  ""+ /!! +. -+ :  ! ""+    "&- '"455%( !  +;++ +.      * %3   '7#K25>?( /!+75 >7> '>8%)>32( '>6$)>>8( %7 25 '57)65( '56)6$( 5% I52 '5)23( '1( I52 I52 '1( '1( I52 I52 '1( '1( 25 53 '5)2$( '5)27(

%> '23)7%(

2% 7# '%%)258(

%3 87 '%7)227(

#% 88 '%5)27>(

#$

7# '28)>>(

""

2> '57)86(

28 '5$)87(

23 '25)65(

#5 '2>)75(

22 '5$)27(

>>5 >7> >7% >32 >32 '>72)>>$( '>$%)>33( '>82)>>8( '33#)>>3( '3#$)>3>( 5$ 2$ 2# 26 2> '5#)2>( '5%)%8( '56)#6( '5)$6( '2%)28#( I52 I52 I52 I52 I52 '1( '1( '1( '1( '1( I52 I52 I52 I52 I52 '1( '1( '1( '1( '1( I52 I52 I52 I52 I52 '1( '1( '1( '1( '1( 56 5> 53 5> 57 '5)23( '5)%6( '5)#5( '5)8#( '5)%7(

82 '%2)2##(

%6



-    % . #       6 %-   %

        #         - )            *441   %*4416 )  -  - 

#  &  # 74*1    

L &)  

L,!  )& )  

L)& )  

L &-)  

L/! ")& )  

L,-!&-)  

L  )  

/  '25>?(



1   

 0    '     +   )



!"# 

+.*&&   &-)  (  0 &2+     * 16  13  126    +   1%5  1$$    .     &  ! ! +. *  &- = -  56L)25L *  *,) & !&!+"  !  & & 1 +  ") &-  ! "& * " &)     . 28  #L  *& & * ! .  +. * " &)    *  "&- '"45558(  ! ! !!     #$      '(  0( "+!"&& 22L+& .!  +.*" &)    -  #      - & .  "  "               '45##  "45528(  *  +      -8% 

 * ! !-)"            ,    +'+#$-  9%       - +& &    #             &&" (       *  /   +01201 '    ,13%%  & " &)              *  #            34440)       :; ,     &  /! +. *    - +  " + *+ "& +"& " * +!!" /! +.* &!"& +" !".%3#$ '(  ( . +.*  &"& +"&"&+"+ & *!+    %3  #$       ! **&  & - *& '.! "4556( ;   ""+   +. ! &   +     '"45552(&+"+."& +" .!'""+(+. + !*+ "++ + "&- ! +

)

2% )

%5 )

%6

%3

#%

#$

""



%#K'p( ## %#K'p( 7% '22)68( '2>)$$( '2%)8$( '%$)%63( L  )   >8%'p( >85K'p( >#% >35 ) ) ) '>55)>33( '>%6)>36( '3%6)>3>( '372)>>%( L,-!&-)   8#K'n( %>'n( 63'n( 22 ) ) ) '28)2%#( '5$)83( '57)2%$( '5#)2%$( L/! ")& )   5$ 56 I52 I52 ) ) ) '5)8#( '5)6#( '1( '1( L &-)   %2K'n( 2#K'n( 28K'n( I52 ) ) ) '5>)#8( '5)#7( '5%)#$( '1( L)& )   I52 I52 5#K'n( I52 ) ) ) '1( '1( '5)53( '1( L,!  )& )   5$ 53 2% 58 ) ) ) '5)53( '5)#5( '56)6>( '5)22( L &)   %% #> 8$ 5> ) ) ) '2#)##( '2#)255( '23)25#( '52)$%( #         %-   %

        #         - )      

    *441   %*441 )       #             7440      ()n   p          #               &   #  74*1    -  - 

#   ?4*1+     )            =     A '      %  .   # )#   =