CHEM 314- Biochemistry

CHEM 314- Biochemistry Meets 8/26/2013 through 12/13/2013 TR 6:30p-7:45p Location: STC135 COURSE DESCRIPTION This introductory course in biochemistry is intended to provide undergraduate and graduate students with a foundation and in depth knowledge of biochemistry. This course will be covering many aspects of biochemistry, including: biomolecules and metabolism. The course consists of lectures sessions and the topic covered will be given in details in the course schedule. In addition to the lectures, 2 modules of Problem Based Learning Activity (PBL) will be conducted to introduce students to biochemistry and its relationship to other disciplines. This activity will provide an opportunity to the students to interact and work as a team to apply their knowledge in basic biochemistry to practical scenarios (research problems, case studies and scientific publications).

COURSE GOALS Students who successfully complete this course will be able to: The main objectives of this course are to provide a basic foundation and understanding of the principles of modern biochemistry necessary for further work in the biochemical/biomedical areas. Unlike much earlier chemistry the material is often conceptually complex and not yet amenable to straightforward mathematical interpretation. Accordingly, the students may find the material more heavily descriptive than in their earlier chemical studies. By the end of this course the students will have a better understanding of the structure and function of the biological macromolecules its metabolism and biosynthesis. Student Learning Outcomes (SLO) At the completion of this course students should have the knowledge to  Identify the levels of structure in proteins and explain the structural stabilization.  Describe the relationship of structure and function of proteins.  Interpret plots of enzyme kinetic data.  Describe the primary metabolic pathways of major molecular classes

REQUIRED TEXTBOOK (S) Required Text Book: Lehninger, Principles of Biochemistry, Fourth Edition, ISBN- 07167- 4339- 6 REQUIRED JOURNAL ARTICLE (S) Lectures and other supplementary materials (Journal articles, case study material and assignments and quizzes) will be email to the students before the session. RECOMMENDED TEXTBOOK (S)/READING (S) Recommended for additional reading BIOCHEMISTRY by Stryer, 7th edition Biochemistry by Garrett and Grisham. Biochemistry by Mathews and Van Holde EXAMS There will be three equally weighted exams given, two during the course and the third at the final exam time. The Students will be expected to be available and prepared for the exams at the specified times. Missing an exam will result in a 0 score for that exam unless due to illness as documented by a doctor's note and the

student notifies the instructor of the illness before the exam (e-mail, phone message, etc.). Make-up exams will not be given ordinarily. The exams will contain a mix of multiple choice questions, long (explanation) questions, short (formulas and definitions) questions and graphical/diagrammatic questions. COURSE GRADING Grading: Your final grade is based on the performance in 3 exams (20% each), Problem Based Learning Activity (PBL)/quizzes (20%) and the final exam (20%) Grading will be based on a standard percentage scale: 100-90 = A; 89-80 = B; 79-70 = C; 69-60 = D; 59-below = F. Dishonest scholarship will earn an automatic zero (0) and initiate prosecution to the fullest extent. Incomplete grades may be given only if the student has a current average ³70% and is precluded from completion of the course by a documented illness or family crisis. COURSE SCHEDULE Date Topic August 27 ABC’s of Biochemistry Ch. 1 29 Water and buffers Ch 2 September 3 Amino acids peptides and protein Ch. 3 5 Protein structure and function Ch.4 and 5 10Problem Based Learning Activity 1 12 Nucleic acids, regulation of gene expression– Ch 8, 17 No class 19 Enzymes Kinetics – Ch 6 24 review 26 FIRST TEST October 1 Carbohydrates Ch 7 3 Lipids 10 8 Membrane Transport& Biosignaling Part-I - Ch. 11&12 10 Membrane Transport& Biosignaling Part-II - Ch. 11&12 15 Glycolysis, Gluconeogenesis and Pentose phosphate Pathway Ch. 14 17-23 No Class 24 - Review for SECOND TEST 29 SECOND TEST 31 Citric Acid Cycle Ch. 16 November 5 Lipid metabolism Ch. 17 and 21 7 Urea Cycle, Amino Acid metabolism Ch. 18 and 22 12 Oxidative Phosphorylation Ch. 19 14 (Problem Based Learning Activity 2) 19 Hormonal regulation and Integration of Metabolism Ch 23 21 Exam Review 26 THIRD TEST 28 Thanksgiving Holiday December 3 Review Dec 2nd week Cumulative final

ALL DATES AND ASSIGNMENTS ARE TENTATIVE AND SUBJECT TO CHANGE Problem Based Learning Activity (PBL) - Biochemistry and its relationship to other disciplines Will provide an opportunity to the students to interact and work as a team to apply their knowledge in basic biochemistry to practical scenarios ( research problems, case studies and scientific publications). Special Needs and Accommodations Please advise the instructor of any special problems or needs at the beginning of the semester. The Americans with Disabilities Act (ADA) is a federal anti-discrimination statute that provides comprehensive civil rights protection for persons with disabilities. Among other things, this legislation requires that all students with disabilities be guaranteed a learning environment that provides for reasonable accommodation of their disabilities. If you have a disability requiring an accommodation, please contact: Office of Student Disability Resources and Services Texas A&M University-Commerce Gee Library, Room 132 Phone (903) 886-5150 or (903) 886-5835 Fax (903) 468-8148 [email protected]