Childhood?onset disease as a predictor of ... - Wiley Online Library

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as having graduated high school or less, some college/ trade school, or a college degree or higher. The percentage of participants living below the poverty level, ...
Arthritis Care & Research Vol. 62, No. 8, August 2010, pp 1152–1159 DOI 10.1002/acr.20179 © 2010, American College of Rheumatology

ORIGINAL ARTICLE

Childhood-Onset Disease as a Predictor of Mortality in an Adult Cohort of Patients With Systemic Lupus Erythematosus AIMEE O. HERSH, LAURA TRUPIN, JINOOS YAZDANY, PETER PANOPALIS, LAURA JULIAN, PATRICIA KATZ, LINDSEY A. CRISWELL, AND EDWARD YELIN

Objective. To examine childhood-onset disease as a predictor of mortality in a cohort of adult patients with systemic lupus erythematosus (SLE). Methods. Data were derived from the University of California Lupus Outcomes Study, a longitudinal cohort of 957 adult subjects with SLE that includes 98 subjects with childhood-onset SLE. Baseline and followup data were obtained via telephone interviews conducted in 2002–2007. The number of deaths during 5 years of followup was determined and standardized mortality ratios (SMRs) for the cohort, and across age groups, were calculated. Kaplan-Meier life table analysis was used to compare mortality rates between childhood- (defined as SLE diagnosis at