None but CHM311 is a pre requisite for Organic Synthesis I and II. 4 ...
Stereochemistry and conformational analysis (Chapters 16 & 18, Clayden): 8 h. 5
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Course code and title
CHM 311 Physical Organic Chemistry
2
Credits:
4 Credits
3 5 4
Course Coordinator Pre requisites Objectives (goals, type of students for whom useful, outcome etc)
Dr. Harinath Chakrapani (
[email protected]) None but CHM311 is a pre requisite for Organic Synthesis I and II. The primary objective of this course is to expose students to the concepts of structure and function in organic chemistry. The use of kinetics, thermodynamics and stereochemistry to understand outcomes of reactions will be discussed. The students will use quantitative methods to understand mechanisms and at the end of this course, students will be in a position to understand and predict reactivity patterns and propose reasonable mechanisms.
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Course contents 1. Basic concepts of acidity, basicity, and pKa (Chapter 8, Clayden): 2 h 2.
Equilibria, kinetics and basic mechanistic principles (Chapter 13, Clayden): 4 h
3.
Determining reaction mechanisms: (Chapter 41, Clayden) 6 h
4.
Stereochemistry and conformational analysis (Chapters 16 & 18, Clayden): 8 h
5.
Pericyclic reactions (Chapters 35, 36, Clayden): 12 h
6.
Rearrangements (Chapter 37, Clayden): 3 h
7.
Reactions of radicals and carbenes (Chapter 39, 40 Clayden): 3 h
8.
Mechanisms in Biological Chemistry (Chapter 50, Clayden): 2 h
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Evaluation
7
Text Books‡
8
Reference Books
9
Schedule
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Notes
11
Office Hours
12
Teaching Assistant
a. Problem Set 1: 15%: Submission Date, Friday Sep 13, 2013† b. Mid-sem examination: 35 % (as per Institute Schedule); 2 h c. Problem Set 2: 15%: Monday, Nov 15, 2013, 2013† d. End-sem examination: 35 % (as per Institute Schedule); 2 h Clayden, J.; Greeves, N.; Warren, S.; Wothers, P. Organic Chemistry. Oxford University Press, 1st Edition. (Primary) Anslyn, E.; Dougherty, D. A.; Modern Physical Organic Chemistry, 1st edition, 2006. University Science Books. Sundberg, R. J.; Carey, F. A. Advanced Organic Chemistry, Part A: Structure and Mechanism, 4th Edition. Kluwer/Plenum Press, 2000. Isaacs, N. Physical Organic Chemistry, 2nd Edition, Addison-WesleyLongman, 1995. Monday, 10:30-11:25 (201) Institute rules regarding Tuesday, 3:30-4:25 (201) attendance will be followed Thursday, 2:30-3:25 (201) †You can discuss/collaborate amongst yourselves but the final submitted version of your solutions must be yours. You will also be expected to defend your answers during discussions in class. Wednesday 10-11 AM (111 Mendeleev Block) You can also email me for an appointment to meet Venkateswararao Boddu (Venky);
[email protected]
