Chronic Parathyroid Hormone Excess In Vivo Increases Resting ...

Chronic Resting Studies Failure’ Miroslaw

Parathyroid Hormone Excess In Vivo Increases Levels of Cytosolic Calcium in Brain Synaptosomes: in the Presence and Absence of Chronic Renal

Smogorzewski,

M. Smogorzewski, 5G.

Massry,

P. Koureta, Division

of Medicine,

Pany

of

University

Koureta,

G.Z.

Faddar,

Nephrology

Los Angeles,

(J. Am.

Soc. Nephrol.

A.F.

and

of Southern

Medicine,

George

Z. Fadda,

School

of

CA

1991; 1:1162-1

F. Perna,

168)

0.0 1) lower

between

administration

ments

that excess renal failure

of PTH to normal

in norepinephrine

parathyroid hor(CRF) or chronic

rats caused

and

derange-

phospholipid

metabo-

a decrease

In the

study

cytosolic

ured (2)

in synaptosomal

presented

calcium

in brain

in six groups rats

with

here,

content

the

resting

synaptosomes

than

that

in normal

CRF of 21-days

of

cemic

parathyroidectomized rats with CRF of 21-days duration; (4) rats with CRF of 2 1-days duration treated with

verapamil

treated rats

with

treated

cytosolic

(437 (428

from

day

verapamil with

±

calcium 18.0 nM)

±

5.6 nM)

I of CRF;

normal

(5)

for 21 days;

and

2 1 days.

Resting

PTH for

were

significantly

(P