Lydia Suh, BSc2, James E. Norton, MS2, Kathryn E. Hulse, PhD2, Atsushi. Kato, PhD2, Robert P. Schleimer, PhD2, Bruce K. Tan, MD1; 1Department.
Abstracts AB285
J ALLERGY CLIN IMMUNOL VOLUME 137, NUMBER 2
Chronic Rhinosinusitis Patients with Gastroesophageal Reflux Disease Have Significantly Higher Prevalence of Atopic Conditions
Erica L. Palmisano, MD1, Mohamed Benhammuda2, Arpita Mehta2, Mary C. Tobin, MD2, Christopher D. Codispoti, MD, PhD2, Sindhura Bandi, MD2, Pete Batra, MD3, Phillip LoSavio, MD3, Robert P. Schleimer, PhD4, Mahboobeh Mahdavinia, MD, PhD2; 1Allergy/ Immunology section, Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL, 2Department of Immunology and Microbiology, Allergy/Immunology Section, Rush University Medical Center, Chicago, IL, 3Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, IL, 4Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL. RATIONALE: Chronic rhinosinusitis (CRS) is characterized by chronic inflammation in the nasal and paranasal sinus mucosal membranes and is associated with increased risk of gastroesophageal reflux disease (GERD). However the mechanism underlying the link between CRS and GERD and the risk factors for GERD in patients with CRS are unknown. METHODS: We investigated the diagnosis of GERD in a large cohort of patients with CRS between 2005-2015. The diagnosis of GERD was based on positive symptoms of heartburn/regurgitation plus response to empiric therapy with PPI. Cases with possible diagnosis without evidence for treatment or positive GI diagnostic results were excluded. Charts were then evaluated for presence or absence of asthma, allergic rhinitis, eczema and food allergy. Comparisons between groups were assessed by using logistic regression; all analyses were adjusted for age, gender and BMI. RESULTS: Our cohort included 1005 patients with documented diagnosis of CRS; 211(20.9%) had GERD. Patients with CRS and GERD were predominantly female, and had higher BMI and age compared to CRS without GERD. CRS and GERD patients had higher prevalence of asthma (47.4% vs 26.6%, p
