John Ross, Jr., La Jolla, California. Abraham M. Rudolph, San Francisco, California. David C. Sabiston, Jr., Durham, North Carolina. David J. Sahn, San Diego, ...
CIRCULATION Editor-in-Chief: Burton E. Sobel, St. Louis, Missouri Associate Editors Michael E. Cain, St. Louis, Missouri Peter B. Corr, St. Louis, Missouri Edward M. Geltman, St. Louis, Missouri Philip A. Ludbrook, St. Louis, Missouri Gustav Schonfeld, St. Louis, Missouri Managing Editor: Melanie Miller
EDITORIAL BOARD George A. Beller, Charlottesville, Virginia J. Thomas Bigger, Jr., New York, New York Henry W. Blackburn, Minneapolis, Minnesota Eugene Braunwald, Boston, Massachusetts B. Greg Brown, Seattle, Washington L. Maximilian Buja, Dallas, Texas Bernadine Healy Bulkley, Baltimore, Maryland David B. Case, New York, New York Lawrence S. Cohen, New Haven, Connecticut Jay N. Cohn, Minneapolis, Minnesota James L. Cox, St. Louis, Missouri Donald B. Doty, Iowa City, Iowa Stephen E. Epstein, Bethesda, Maryland John J. Fenoglio, Jr., New York, New York Curt D. Furberg, Bethesda, Maryland William H. Gaasch, Boston, Massachusetts Paul C. Gillette, Houston, Texas Stanton A. Glantz, San Francisco, California Joseph C. Greenfield, Jr., Durham, North Carolina William Grossman, Boston, Massachusetts Scott M. Grundy, Dallas, Texas Charles B. Higgins, San Francisco, California Julien 1. E. Hoffman, San Francisco, California Norman K. Hollenberg, Boston, Massachusetts Michiel J. Janse, Amsterdam, The Netherlands Mark E. Josephson, Philadelphia, Pennsylvania Gerard A. Kaiser, Miami, Florida Richard E. Kerber, Iowa City, Iowa Francis J. Klocke, Buffalo, New York Ronald M. Lauer, Iowa City, Iowa Martin J. Lipton, San Francisco, California
Maurice McGregor, Montreal, Quebec, Canada Barry Joel Maron, Bethesda, Marvland Israel Mirsky, Boston, Massachusetts Russell M. Nelson, Salt Lake City, Utah Robert A. O'Rourke, San Antonio, Texas Michael Oliver, Edinburgh, Scotland Sven J. Paulin, Boston, Massachusetts Joseph K. Perloff, Los Angeles, California Gerald M. Pohost, Boston, Massachusetts Richard L. Popp, Stanford, California Shahbudin H. Rahimtoola, Los Angeles, California James L. Ritchie, Seattle, Washington Michael R. Rosen, New York, New York John Ross, Jr., La Jolla, California Abraham M. Rudolph, San Francisco, California David C. Sabiston, Jr., Durham, North Carolina David J. Sahn, San Diego, California Ernst J. Schaefer, Boston, Massachusetts James Scheuer, Bronx, New York John S. Schroeder, Stanford, California Madison S. Spach, Durham, North Carolina Jeremiah Stamler, Chicago, Illinois Harold J. C. Swan, Los Angeles, California Henry N. Wagner, Jr., Baltimore, Maryland Myron L. Weisfeldt, Baltimore, Maryland Hein J. J. Wellens, Maastricht, The Netherlands Arthur E. Weyman, Boston, Massachusetts James T. Willerson, Dallas, Texas Roberta Gay Williams, Los Angeles, California Andrew L. Wit, New York, New York Douglas P. Zipes, Indianapolis, Indiana
CONSULTING EDITORS Elliot Rapaport, San Franc isco, California
Julius H. Comroe, Jr., San Francisco, California
PUBLICATIONS COMMITTEE, AMERICAN HEART ASSOCIATION FRANCOIS M. ABBOUD
Iovwa Citv, IA JOHN T. BAKER Chicago, IL H.J. M. BARNETT
London, Ontario, Canada EDWIN L. BIERMAN Seattle. WA JOHN R. BLINKS Rochester, MN
Chairman: Robert M. Berne, Charlottesville, Virginia FREDERICK BOWES 111 FRANK 1. MARCUS
Boston, MA GRACE E. BROWN Madison, WI MARY Jo BURGESS Salt Lake Citv, UT MELVIN D. CHEITLIN San Francisco, CA
THOMAS W. SMITH
Tucson, AZ
Boston, MA
ALLYN MARK
BURTON E. SOBEL St. Louis, MO
Iowa City, IA OSCAR M. REINMUTH
H. ALFRED TYROLER
Pittsburgh, PA
Chapel Hill, NC
EDGAR HABER
THOMAS J. RYAN
FRANK M. YATSU
Boston, MA
Boston, MA
Houston, TX
6
CIRCULATION Editor-in-Chief: Burton E. Sobel, St. Louis, Missouri Associate Editors Peter B. Corr, St. Louis. Missouri Michael E. Cain, St. Louis, Missouri Edward M. Geltman, St. Louis, Missouri Philip A. Ludbrook, St. Louis, Missouri Gustav Schonfeld, St. Louis, Missouri Managing Editor: Melanie Miller
EDITORIAL BOARD Maurice McGregor. Montreal, Quebec, Canada Barry Joel Maron, Bethesda, Mary1land lsrael Mirsky, Boston, Massachusetts Russell M. Nelson, Salt Lake Citv, Utah Robert A. O'Rourke, San Antoniio, Texas Michael Oliver, Edinburgh, Sc.otlaind Sven J. Paulin, Boston, Massachusetts Joseph K. Perloff, Los Angeles, California Gerald M. Pohost, Bostoni, Massachusetts Richard L. Popp, Stanford, Califovrnia1 Shahbudin H. Rahimtoola, Los Angeles, California James L. Ritchie, Seattle, Washingtont Michael R. Rosen, New York, New1 York John Ross, Jr., La Jolla, Cal iftrnia Abraham M. Rudolph, San Francisco, California David C. Sabiston, Jr.. Durham, North Carolina David J. Sahn, Sani Diego, Californiia Ernst J. Schaefer, Bostont, Massachusetts James Scheuer, Brontx, New York John S. Schroeder, Stcanford, Californzia Madison S. Spach, Durham, North Carolina Jeremiah Stamler, Chic.ago, Illinois Harold J. C. Swan, Los Anigeles, Califtnrnia Henry N. Wagner, Jr., Baltimore, Maryland Myron L. Weisfeldt, Baltimore, Maryland Hein J. J. Wellens, Maastricht, The Netherltan.ds Arthur E. Weyman, Bostoni, Massachusetts James T. Willerson, Dallas, Texas Roberta Gay Williams, Los Angeles, California Andrew L. Wit, New York, News York Douglas P. Zipes, Indianapolis, Indiana
George A. Beller, Charlottesville, Virginia J. Thomas Bigger. Jr., Newv York, New! York Henry W. Blackburn, Minneapolis, Minnesota Eugene Braunwald, Boston, Massachusetts B. Greg Brown, Seattle, Washington L. Maximilian Buja, Dallas, Texas Bernadine Healy Bulkley, Baltimore, Maryland David B. Case, Newt! York, New York Lawrence S. Cohen, News Haven, Connecticut Jay N. Cohn, Miinneapolis, Minnesota James L. Cox. St. Louis, Missouri Donald B. Doty. Iowa City. 1o1wa Stephen E. Epstein. Bethesda, Maryland John J. Fenoglio. Jr., New York, New York Curt D. Furberg, Bethesda, Maryland William H. Gaasch, Boston, Massachusett.s Paul C. Gillette, Houston, Te-xas Stanton A. Glantz, San Francisco, California Joseph C. Greenfield, Jr.. Durham, North Carolina William Grossman, Boston, Massachusetts Scott M. Grundy. Dallas, Texnas Charles B. Higgins, Sant Francisco, California Julien 1. E. Hoffman. Sacn Francisco, California Norman K. Hollenberg. Bostoil, Massachusetts Michiel J. Janse, Amsterdam, The Netherlands Mark E. Josephson, Philadelphia, Pennsylvania Gerard A. Kaiser, Miami, Florida Richard E. Kerber. Iowa City, Iowa Francis J, Klocke, Buffalo, New York Ronald M. Lauer, lowa City Iowa Martin J. Lipton. San Francisco, California
CONSULTING EDITORS Julius H. Comroe, Jr., San7 Francisco, California
Elliot Rapaport, Sani Francisco, California
PUBLICATIONS COMMITTEE, AMERICAN HEART ASSOCIATION Chairman: Robert M. Berne. Charlottevsville, Virginia FRANCOIS M. ABBou 1) lowa Citv, IA
FREDERICK BowEs 111 Bostoni, MA
JoH1N T. BAKFR Chicago, IL
Madisoni, WI
H.J.M. BARNETT
London. Onitairio, Canada Ei)wiN L. BIERMAN Seattle, WA JohIN R. BI INKS Rochester MN
Tuicson, AZ
T[hoMAS W. SMIThI Bostoni, MA
Ai. YN MARK low(a Citv, IA
St. Loulis, MO
FRANK I. MARCUR,
GRACF. E. BROWN
MARY Jo BURGESS Salt Lake Cin. UT
BU-IR roN E. SoBi-i
OSCAR M. RihINMlI-rIi
H. AL.FRi-[) TYROI FR
MELVIN D. CHEIT.IN San Francisco, CA
Pittsburgh, PA
Chapel Hill, NC
EDGAR HABER
THlOMAS J. RYAN Boston, MA
Houston, TX
Bostotn, MA
6
FRANK M. YATSLJ