Feb 6, 2018 - chronic kidney disease (CKD); the risk of high SUA in young ... cardiovascular disease. ..... Bjornstad P, et al: Asymptomatic hyperurice-.
Treviño-Becerra A, Iseki K (eds): Uric Acid in Chronic Kidney Disease. Contrib Nephrol. Basel, Karger, 2018, vol 192, pp 125–134 (DOI: 10.1159/000484287)
Clinical Significance of Serum Uric Acid Levels in Mexican Young Adults Araceli Alegría-Díaz a · Rafael Valdez-Ortiz a · Miguel Murguía-Romero b, c · Rafael Jiménez-Flores b, c · Rafael Villalobos-Molina b, c · Srinivas Mummidi d · Ravindranth Duggirala d · Juan C. López-Alvarenga d, e · Monserrat Pérez-Navarro a a Department of Nephrology, Hospital General de México, México City, b Iztacala School of Graduate Studies, National Autonomous University of Mexico (FES-I. UNAM), Tlalnepantla, c National Laboratory in Health: Molecular Diagnosis and Environmental Effect in Chronic-Degenerative Diseases, National Autonomous University of Mexico (UNAM), Tlalnepantla, México; d South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, TX, USA; e Universidad Mexico Americana del Norte, Reynosa Tamaulipas, México
Background: High serum uric acid concentration (SUA >6 for women [W] or 7 mg/dL for men [M]) in adults is an independent risk factor for causing cardiovascular disease and chronic kidney disease (CKD); the risk of high SUA in young population is still being debated. Summary: We conducted an epidemiological study to determine the association between SUA quartiles with cardiometabolic risk factors (CRF) and renal impairment in apparently healthy young adults. CRF (dyslipidemia, overweight [Ow], obesity [Ob], blood pressure [BP], hyperglycemia, insulin resistance [IR]) and renal impairment were defined as glomerular filtration rate (GFR) by CKD-Epidemiology Collaboration formula >130/120, 6/7 mg/dL W/M); hypertriglyceridemia (≥150 mg/dL), low HDL-cholesterol (HDL-c 130 mg/dL), insulin resistance (HOMA-IR, >2.3/2.9 W/M). Metabolic syndrome (MetS) was defined according to the criteria established by the International Diabetes Federation and the American Heart Association/National Heart, Lung, and Blood Institute [13]. GFR was estimated by using the CKD-Epidemiology Collaboration formula; stratifying the values obtained by FGR >130/120 mL/min/1.73 m2 (M/W), FGR normal ≥90–120/90–130 mL/min/1.73 m2 (W/M), and FGR
