Clinicopathological characteristics, treatment and ... - Semantic Scholar

5 downloads 62 Views 482KB Size Report
Jul 24, 2015 - Objective: Uterine carcinosarcoma (UCS) shared the same staging system with endometrial carcinoma in the International Federation of ...
J Gynecol Oncol. 2016 Mar;27(2):e18 http://doi.org/10.3802/jgo.2016.27.e18 pISSN 2005-0380 · eISSN 2005-0399

Original Article

Clinicopathological characteristics, treatment and outcomes in uterine carcinosarcoma and grade 3 endometrial cancer patients: a comparative study Jun Zhu,1 Hao Wen,1 Rui Bi,2 Xiaohua Wu1,3 1

Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China 3 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China 2

Received: Jun 25, 2015 Revised: Jul 24, 2015 Accepted: Jul 31, 2015 Correspondence to Xiaohua Wu Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, China. E-mail: [email protected] Copyright © 2016. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

ORCID Jun Zhu http://orcid.org/0000-0003-1224-2771 Hao Wen http://orcid.org/0000-0002-4217-8937 Rui Bi http://orcid.org/0000-0001-7634-5070 Xiaohua Wu http://orcid.org/0000-0002-6889-3541

http://ejgo.org

ABSTRACT Objective: Uterine carcinosarcoma (UCS) shared the same staging system with endometrial carcinoma in the International Federation of Gynecology and Obstetrics 2009. The aim of the present study was to compare the clinicopathological and prognostic characteristics between UCS and grade 3 endometrioid endometrial carcinoma (G3EC). Methods: A retrospective analysis of 60 UCS and 115 G3EC patients with initial treatment at the Department of Gynecology in the Fudan University Shanghai Cancer Center between February 2006 and August 2013. Chi-square analysis was used to compare differences between variables. Prognostic factors were determined using univariate/multivariate analysis, and the survival rates were assessed using the Kaplan-Meier method. The Cox regression model was used to assess the independent prognostic factor. Results: UCS had significantly worse overall survival (OS) compared with G3EC. Carcinosarcoma subtype was an independent factor (hazard ratio [HR], 2.4; 95% confidence interval [CI], 1.0 to 5.8; p=0.039), stratified based on stage. Compared with G3EC, UCS patients had a greater incidence of ascites fluid (55.0% vs. 15.7%, p