Journal of Cancer Research and Therapeutics - July-September 2014 - Volume 10 - Issue 3. Nasser Samadi1,2,. Parisa Ghanbari1,3,. Mahsa Mohseni1,3,.
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Original Article
Combination therapy increases the efficacy of docetaxel, vinblastine and tamoxifen in cancer cells ABSTRACT Introduction: Developing novel strategies to increase the efficacy of chemotherapy is an urgent need. We investigated the impact of combination therapy with docetaxel, or vinblastine with tamoxifen in inhibition of proliferation and induction of apoptosis in MDA‑MB‑231 and H1299 cells. Materials and Methods: Cell proliferation was assessed by MTT assay and the percentage of apoptotic cells was measured using DAPI staining. Statistical Analysis: Statistical analysis was performed by one‑way ANOVA using SPSS software. Results: Vinblastine or docetaxel induced higher percentage of apoptosis in MDA‑MB‑231 cells than H1299 cells (P
