Comparative Efficacy and Safety of Low-Dose

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Feb 23, 2010 - than 3 times the upper normal limit of alanine aminotransferase or 10 times that ... creased aspartate aminotransferase (AST) (1.5%) or in-.
RESEARCH REPORTS Dyslipidemia

Comparative Efficacy and Safety of Low-Dose Pitavastatin Versus Atorvastatin in Patients with Hypercholesterolemia Nakarin Sansanayudh, Supakit Wongwiwatthananukit, Pawat Putwai, Rawadee Dhumma-Upakorn

oronary heart disease (CHD) remains the leading cause of death globally.1,2 Numerous clinical trials have found that elevated low-density lipoprotein cholesterol (LDL-C) levels play a pivotal role in the pathogenesis of atherosclerosis and that LDL-C–lowering therapy can reduce CHD morbidity and mortality.3-11 Based on these findings, the National Cholesterol Education Program–Adult Treatment Panel III (NCEP-ATP III) has issued treatment guidelines that identify elevated LDL-C as the primary target goal for cholesterol-lowering therapy.12,13 The LDL-C goals, categorized by cardiovascular risk, are high risk (