Comparison of Intravenous Dexmedetomidine and Midazolam for ...
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Abstract. Objective To compare the safety and efficacy of midazolam given intranasally with diazepam given intravenously in the treatment of children with.
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Comparison of Intravenous Dexmedetomidine and Midazolam for ...
Authors’ ABCDEF Contribution: Youn Yi Jo Study Design A BF Dongchul Lee Data Collection B BF Wol Seon Jung Statistical Analysis C Data Interpretation B D Noo Ree Cho Manuscript Preparation E ABDEF Hyun Jeong Kwak Literature Search F Funds Collection G
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Department of Anesthesiology and Pain Medicine, Gachon University Gil Medical Center, Incheon, South Korea
Despite the high frequency of hypotension during spinal anesthesia with proper sedation, no previous report has compared the hemodynamic effects of dexmedetomidine and midazolam sedation during spinal anesthesia. We compared the effects of bispectral index (BIS)-guided intravenous sedation using midazolam or dexmedetomidine on hemodynamics and recovery profiles in patients who underwent spinal anesthesia. One hundred and sixteen adult patients were randomly assigned to receive either midazolam (midazolam group; n=58) or dexmedetomidine (dexmedetomidine group; n=58) during spinal anesthesia. Systolic, diastolic, and mean arterial pressures; heart rates; peripheral oxygen saturations; and bispectral index scores were recorded during surgery, and Ramsay sedation scores and postanesthesia care unit (PACU) stay were monitored. Hypotension occurred more frequently in the midazolam group (P
