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Jul 9, 2014 - 5 Division of Clinical Microbiology, Helsinki University Central ... rence of complement components and regulators in placentae were analyzed.
ORIGINAL RESEARCH ARTICLE published: 09 July 2014 doi: 10.3389/fimmu.2014.00312

Complement activation and regulation in preeclamptic placenta Anna Inkeri Lokki 1,2,3 *† , Jenni Heikkinen-Eloranta 1,4 † , Hanna Jarva 2,3,5 , Terhi Saisto 4 , Marja-Liisa Lokki 6 , Hannele Laivuori 1,4 and Seppo Meri 2,3,5 1

Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland 3 Immunobiology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland 4 Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland 5 Division of Clinical Microbiology, Helsinki University Central Hospital Laboratory (HUSLAB), Helsinki, Finland 6 Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland 2

Edited by: Luis Graca, University of Lisbon, Portugal Reviewed by: Bin Li, Chinese Academy of Sciences, China Lennart T. Mars, National Institute of Health and Medical Research, France *Correspondence: Anna Inkeri Lokki , Biomedicum/LGO, Helsingin yliopisto, Haartmaninkatu 8, Helsinki 00014, Finland e-mail: [email protected]

Anna Inkeri Lokki and Jenni Heikkinen-Eloranta have contributed equally to this work.

Preeclampsia (PE) is a common disorder of pregnancy originating in the placenta. We examined whether excessive activation or poor regulation of the complement system at the maternal–fetal interface could contribute to the development of PE. Location and occurrence of complement components and regulators in placentae were analyzed. Cryostat sections of placentae were processed from 7 early-onset PE (diagnosis