Compound 4 Compound 11-(S) Compound 12-(S) - PLOS

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10-9. 10-8. 10-7. 10-6. 10-5. 10-4. -50. -25. 0. 25. 50. 75. 100. -25. 0. 25. 50. 75. 100. Compound concentration (M). % of In h ibitio n on in fe c te tion of e x tra c e.
10 -7

10 -6

10 -5

10 -4

125

100

100

75

75

50

50

25

25

0

0

-25 10 -9

10 -8

10 -7

10 -6

10 -5

-25

10 -4

100

75

75

50

50

25

25

0 -25

0

-50 10 -9

-25

10 -8

10 -7

10 -6

10 -5

Compound concentration (M)

10 -4

10 -5

-25 10 -4

Compound concentration (M)

Compound 6 125

125

100

100

75

75

50

50

25

25

0 -25

0

-50 10 -9

-25

10 -8

10 -7

10 -6

10 -5

10 -4

Compound 10-(S) 125

125

100

100

75

75

50

50

25

25

0 -25

0

-50 10 -9

-25

10 -8

10 -7

10 -6

10 -5

Compound concentration (M)

10 -4

50

50

25

25

0 -25

0

-50 10 -9

-25

10 -8

10 -7

10 -6

10 -5

10 -4

Compound concentration (M)

Compound 7 125

125

100

100

75

75

50

50

25

25

0 -25

0

-50 10 -9

-25

10 -8

10 -7

10 -6

10 -5

10 -4

Compound concentration (M)

Compound 11-(S) 125

125

100

100

75

75

50

50

25

25

0 -25

0

-50 10 -9

-25

10 -8

10 -7

10 -6

10 -5

Compound concentration (M)

10 -4

100

75

75

50

50

25

25

0

0

-25 -50 10 -9

10 -8

10 -7

10 -6

10 -5

-25 10 -4

Compound concentration (M)

Compound 8 125

125

100

100

75

75

50

50

25

25

0

0

-25 -50 10 -9

10 -8

10 -7

10 -6

10 -5

-25 10 -4

Compound concentration (M)

Compound 12-(S) 125

125

100

100

75

75

50

50

25

25

0

0

-25 -50 10 -9

10 -8

10 -7

10 -6

10 -5

Compound concentration (M)

-25 10 -4

% of inhibition of extracellular growth

100

10 -6

75

% of inhibition of extracellular growth

125

10 -7

% of inhibition of o extracellular growth

Compound 9 125

10 -8

Compound concentration (M)

% of inhibition of o extracellular growth

% of Inhibition on infected cells

Compound concentration (M)

-50 10 -9

75

125

100

% of inhibition of extracellular growth

Compound 5 125

0

-25

% of inhibition n of extracellular growth

% of inhibition n of extracellular growth

% of Inhibition on inffected cells

Compound concentration (M)

0

100

% of Inhibition on infe ected cells

-25

25

125

100

% of Inhibition on in nfected cells

0

-50 10 -8

50

25

125

% of Inhibition on infected cells

-25

75

50

% of Inhibition on infec cted cells

0

100

75

% of Inhibition on in nfected cells

25

100

% of Inhibition on infected cells

25

% of Inhibition on infecte ed cells

50

% of Inhibition on inffected cells

50

% of Inhibition on in nfected cells

% of Inhibition on infec cted cells

75

125

Compound 4 125

% of inhibitio on of extracellular growth

75

125

% of inhibition of extracellular growth

100

Compound 3

% of inhibitiion of extracellular growth

100

Compound 2

% of inhibition of extracellular growth

125

% of inhibitio on of extracellular growth

Compound 1 125