CONCEPT: COOH DERIVATIVES AND NUCLEOPHILIC ACYL ...
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CONCEPT: COOH DERIVATIVES AND NUCLEOPHILIC ACYL ...
Carboxylic acid derivatives are defined as any carbonyl with a single electronegative group (-Z) in the α-position. â
CONCEPT: COOH DERIVATIVES AND NUCLEOPHILIC ACYL SUBSTITUTION Carboxylic acid derivatives are defined as any carbonyl with a single electronegative group (-Z) in the α-position. ● These follow unique nucleophilic mechanism due to the presence of a leaving group, called NAS. ● By definition, they can ALL be hydrolyzed to a carboxylic acid using water with acid or base.
□ Nitriles also fall into this category due to their ability to be hydrolyzed = -Cl, -COOR -OR, -OH, - NH3
