CONCEPT: REDUCTIVE AMINATION Recall that ketones and ...
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CONCEPT: ALDOL CONDENSATION. Via enolates, ketones and aldehydes will react with. to condensate into. â The final prod
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CONCEPT: REDUCTIVE AMINATION Recall that ketones and ...
CONCEPT: REDUCTIVE AMINATION. Recall that ketones and aldehydes can react with primary amines in acidic conditions to fo
CONCEPT: REDUCTIVE AMINATION Recall that ketones and aldehydes can react with primary amines in acidic conditions to form imines. ● This mechanism passed through an important intermediate called an iminium cation.
Ketones and aldehydes can be made to form amines instead by using the reducing agent, NaBH3CN on the imine.
● This mechanism starts the same, except for the fact that we reduce the imine instead of deprotonating it
EXAMPLE: Provide the major product for the following reaction.
![Reductive Amination with [11C]Formaldehyde: A Versatile Approach ...](https://m.moam.info/img/260x300/reductive-amination-with-11cformaldehyde-a-versati_5ac8d8371723ddfe3312ae56.jpg)