CONCEPT: USE OF PROTECTING GROUPS Organometallics are ...
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CONCEPT: USE OF PROTECTING GROUPS Organometallics are ...
Organometallics are powerful bases. They will react with any acidic protons available, ruining the reagent. We can use t
CONCEPT: USE OF PROTECTING GROUPS
□ Organometallics are powerful bases. They will react with any acidic protons available, ruining the reagent.
We can use tert-butyl or silyl ethers to protect alcohols from deprotonation by organometallic reagents ● p-Toluenesulfonic acid is an acid commonly used for this step (abbrev. TsOH or pTSA)
EXAMPLE: Provide the mechanism and final product for the following transformation
