Conclusive evidence of endotoxaemia in biliary ... - Europe PMC
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Conclusive evidence of endotoxaemia in biliary obstruction W D B Clements, P Erwin, M D McCaigue, I Halliday, G R Barclay, B J Rowlands
Department of Surgery, The Queen’s University of Belfast W D B Clements P Erwin M D McCaigue I Halliday B J Rowlands Edinburgh Blood Transfusion Service G R Barclay Correspondence to: Mr W D B Clements, Department of Surgery, Institute of Clinical Science, Grosvenor Road, Belfast BT12 6BJ, UK. Accepted for publication 24 June 1997
Abstract Background—Endotoxaemia is implicated in the pathophysiology of obstructive jaundice. The EndoCab enzyme linked immunosorbent assay (ELISA) is a novel assay which measures endogenous antibody (IgG) to the inner core region of circulating endotoxins (ACGA). Aims—To investigate the significance of endotoxaemia in biliary obstruction using the EndoCab assay and assess the specificity of the humoral response to endotoxin compared with an exogenous antigenic challenge (tetanus toxoid, TT). Methods—Three groups of adult male Wistar rats were studied: no operation, sham operation, and bile duct ligation for 21 days (BDL). In the second study, rats rats received prior immunisation with TT. Results—In the preliminary experiment, plasma ACGA was significantly increased in the BDL group (306.6 (18.3)% versus 119.9 (6.7)% and 105.2 (4.6)% in the sham and no operation groups, respectively; p
