Short Article
Conformational Plasticity of the Immunoglobulin Fc Domain in Solution Graphical Abstract
Authors Soumya G. Remesh, Anthony A. Armstrong, Andrew D. Mahan, Jinquan Luo, Michal Hammel
Correspondence
[email protected] (J.L.),
[email protected] (M.H.)
In Brief Fragment crystallizable (Fc) region of immunoglobulin G controls antibody effector function through specific Fc receptors interaction. Remesh et al. developed and applied an all-atom solution scattering-based modeling tool to reveal biologically relevant conformational plasticity of the Fc isotypes. This inexpensive SAXS-based approach can also aid typical antibody engineering efforts.
Highlights d
Experimental visualization of Fc flexibility in solution
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Flexibility variation observed between Fc isotypes in solution
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All-atom modeling provides an accurate conformational sampling of glycoproteins
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SAXS utilized to model
