Contribution of innate cortical mechanisms to the maturation of ...

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Dec 12, 2016 - Alerts: Sign up at www.jneurosci.org/cgi/alerts to receive customized email alerts when the fully formatted version of this ... Tables: 1. 14. Abstract: 197 ..... transplanted PV neurons were found to be responsive (table 1). 288.
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Research Articles: Development/Plasticity/Repair

Contribution of innate cortical mechanisms to the maturation of orientation selectivity in Parvalbumin interneurons Dario X. Figueroa Velez1, Kyle L. Ellefsen1, Ethan R. Hathaway1, Mathew C. Carathedathu1 and Sunil P. Gandhi1 1

Department of Neurobiology and Behavior; University of California, Irvine, CA, 92697; USA

DOI: 10.1523/JNEUROSCI.2386-16.2016 Received: 27 July 2016 Revised: 30 November 2016 Accepted: 7 December 2016 Published: 12 December 2016

Author contributions: D.X.F., K.L.E., E.R.H. and S.P.G. designed the experiments. D.X.F. performed the transplantation procedures. D.X.F recorded and analyzed two-photon calcium imaging data. K.L.E. and M.C.C. developed acquisition and analysis routines for the two-photon and optical imaging experiments. D.X.F. and S.P.G. wrote the manuscript with input from K.L.E. and E.R.H. Conflict of Interest: The authors have no competing financial interests associated with this work. We are grateful to J. Cang and F. Weghorst for providing a critical reading of the manuscript. We would also like to thank V. Jayaraman, R. Kerr, D. Kim, L. Looger, and K. Svoboda from the GENIE Project, Janelia Farm Research Campus, Howard Hughes Medical Institute for making the GCaMP6s vectors available. Confocal imaging was made possible by the Optical Biology Shared Resource of the UCI Cancer Center Support Grant (CA-62203). This work was supported by a NIH Director's New Innovator Award (DP2 EY024504-01), a Whitehall Grant, a Searle Scholars Award and a Klingenstein Fellowship. K.L.E. and E.R.H. were supported by a predoctoral training grant from the Department of Education GAANN program. Corresponding author: Sunil P. Gandhi, 2213 McGaugh Hall, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-4550. [email protected] Cite as: J. Neurosci 2016; 10.1523/JNEUROSCI.2386-16.2016 Alerts: Sign up at www.jneurosci.org/cgi/alerts to receive customized email alerts when the fully formatted version of this article is published.

Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. Copyright © 2016 the authors

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