RESEARCH ARTICLE
Correlation between plasma endothelin-1 levels and severity of septic liver failure quantified by maximal liver function capacity (LiMAx test). A prospective study Magnus F. Kaffarnik1*, Navid Ahmadi1, Johan F. Lock1,2, Tilo Wuensch1, Johann Pratschke1, Martin Stockmann1, Maciej Malinowski1,3
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1 Charite´–Universita¨tsmedizin Berlin, Department of General, Visceral and Transplantation Surgery, Augustenburger Platz 1, Berlin, Germany, 2 University Hospital of Wuerzburg, Department of General-, Visceral-, Vascular- and Paediatric Surgery, Wuerzburg, Germany, 3 University Hospital of Homburg, Department of General-, Visceral-, Vascular- and Paediatric Surgery, Homburg, Germany *
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Abstract OPEN ACCESS Citation: Kaffarnik MF, Ahmadi N, Lock JF, Wuensch T, Pratschke J, Stockmann M, et al. (2017) Correlation between plasma endothelin-1 levels and severity of septic liver failure quantified by maximal liver function capacity (LiMAx test). A prospective study. PLoS ONE 12(5): e0178237. https://doi.org/10.1371/journal.pone.0178237 Editor: Chiara Lazzeri, Azienda Ospedaliero Universitaria Careggi, ITALY Received: July 12, 2016 Accepted: April 28, 2017 Published: May 23, 2017 Copyright: © 2017 Kaffarnik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: The study was funded by research grants of the Charite´—University Hospital, Berlin. B.R.A.H. M.S. GmbH (Hennigsdorf, Germany) supported this study by provision of CT-proET-1 assay kits (BRAHMS CRproET1 Kryptor, Material Transfer Agreement). This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Aim To investigate the relationship between the degree of liver dysfunction, quantified by maximal liver function capacity (LiMAx test) and endothelin-1, TNF-α and IL-6 in septic surgical patients.
Methods 28 septic patients (8 female, 20 male, age range 35–80y) were prospectively investigated on a surgical intensive care unit. Liver function, defined by LiMAx test, and measurements of plasma levels of endothelin-1, TNF-α and IL-6 were carried out within the first 24 hours after onset of septic symptoms, followed by day 2, 5 and 10. Patients were divided into 2 groups (group A: LiMAx 100 μg/kg/h, moderate liver dysfunction; group B: LiMAx
