Data on prevalence and risk factors associated with ...

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1 Contents lists available at ScienceDirect 2 3 4 5 6 journal homepage: www.elsevier.com/locate/dib 7 8 9 Data Article 10 11 12 13 14 15 Q6 16 17 18 Márcia B. Silva a, Ana L.M. Amor b, Leonardo N. Santos a, 19 Alana A. Galvão a, Aida Y. Oviedo V a, Eduardo S. Silva a, 20 21 Cynara Gomes Barbosa c, Philip J. Cooper d,e, 22 Camila A. Figueiredo a, Rita de Cassia Ribeiro f, 23 a,n 24 Q1 Neuza Maria Alcântara-Neves a 25 Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, Brazil b Centro de Ciências da Saúde. Universidade Federal do Recôncavo da Bahia, Santo Antônio de Jesus, 26 Bahia, Brazil 27 c Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Bahia, Brazil 28 d Facultad de Ciencias Medicas, de la Salud y la Vida, Universidad Internacional del Ecuador, Quito, Ecuador e 29 St George’s University of London, Division of Clinical Sciences, Cranmer Terrace, London SW17 ORE, UK f Escola de Nutrição, Universidade Federal da Bahia, Salvador, Brazil 30 31 32 33 a r t i c l e i n f o abstract 34 Article history: 35 In the present article, we provide shortly, data on risk factors for Received 12 April 2016 acquiring Toxocara spp. infection and investigate possible asso36 Received in revised form ciations between this infection with atopy and asthma in school 37 11 August 2016 children of a small town and its semi-rural areas of Northeast 38 Accepted 22 August 2016 Brazil. The data set are composed by demographic, social and 39 home environment variables. The detection of anti-Toxocara spp. 40 Keywords: IgG and specific IgE to aeroallergens was determined by ELISA and 41 Risk factors ImmunocAP/Phadiatrope systems, respectively. The data presented 42 in this article are related to the article entitled “Risk factors for 43 44 45 DOI of original article: http://dx.doi.org/10.1016/j.actatropica.2016.04.005 n Correspondence to: Laboratório de Alergia e Acarologia, Instituto de Ciências da Saúde, Universidade Federal da Bahia, 46 Avenida Reitor Miguel Calmon, sem nº, Canela, CEP: 40110-100, Salvador, Bahia, Brazil. 47 E-mail addresses: [email protected] (M.B. Silva), [email protected] (A.L.M. Amor), 48 [email protected] (L.N. Santos), [email protected] (A.A. Galvão), [email protected] (A.Y. Oviedo V), 49 [email protected] (E.S. Silva), [email protected] (C.G. Barbosa), [email protected] (P.J. Cooper), cavfi[email protected] (C.A. Figueiredo), [email protected] (R.d.C. Ribeiro), 50 [email protected] (N.M. Alcântara-Neves). 51 52 http://dx.doi.org/10.1016/j.dib.2016.08.062 53 2352-3409/& 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license 54 (http://creativecommons.org/licenses/by/4.0/).

Data in Brief

Data on prevalence and risk factors associated with Toxocara spp infection, atopy and asthma development in Northeast Brazilian school children

Please cite this article as: M.B. Silva, et al., Data on prevalence and risk factors associated with Toxocara spp infection, atopy and asthma development in Northeast Brazilian school children, Data in Brief (2016), http://dx.doi.org/10.1016/j.dib.2016.08.062i

M.B. Silva et al. / Data in Brief ∎ (∎∎∎∎) ∎∎∎–∎∎∎

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Toxocara spp, Atopy Wheezing/Asthma

Toxocara spp. seroprevalence and its association with atopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil” (M.B. Silva, A.L. Amor, L.N. Q2 Santos, A.A. Galvão, A.V. Oviedo Vera, E.S. Silva et al., 2016) [1]. & 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Specifications Table Subject area More specific subject area Type of data How data was acquired Data format Experimental factors Experimental features Data source location Data accessibility

Epidemiology, alergology Immunoparasitology Figure, Table ELISA, ImmunoCAP and Phadiatrope Analyzed Stool and blood samples, and sera for measurement of allergen-specific IgE and anti-Toxocara spp. IgG Immunoassay Federal University of Bahia, Salvador, Bahia, Brazil Data is available with this article

Value of the data

These data set will be of value for the scientific community who work in the area of infectious diseases since it involves the risk factors related to Toxocara spp. infection.

The data will also be of value for studies in the area of allergy and its interface with helminthic diseases, since they report an association of Toxocara spp. infection with aeroallergen specific IgE.

These data reinforce the hypothesis that this association may be related to the cross-reactivity between parasite-specific and aeroallergen-specific IgE.

1. Data The data demonstrate obtained in this work is summarized in Fig. 1 and Table 1. Fig. 1 shows that being male and having contact with dogs and cats were risk factors for Toxocara spp. infection among other variables studied. Table 1 shows the analysis of Toxocara spp. infection as risk factors for atopy and asthma. We found that Toxocara spp. seropositive school age children were more prone to have positive serum aeroallergen-specific IgE.

2. Experimental design, materials and methods The data presented in this paper investigated the risk factors to acquire Toxocara spp. infection and its association with atopy and asthma. It reports the data obtained in a study conducted in a small city of Northeast Brazil with 791 school-age children. Students underwent an epidemiological survey answered by their parents on sanitation, social class and risk factors for toxocariasis. Moreover, they answered an ISAAC Portuguese-adapted questionnaire for asthma diagnosis [2]. Blood collection was Please cite this article as: M.B. Silva, et al., Data on prevalence and risk factors associated with Toxocara spp infection, atopy and asthma development in Northeast Brazilian school children, Data in Brief (2016), http://dx.doi.org/10.1016/j.dib.2016.08.062i


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Fig. 1. ORs and 95% confident intervals calculated by logistic analysis model adjusted by age, sex, contact with dogs and cats, school location, maternal schooling, family income and helminth infection.

Table 1 Association between Toxocara spp. seropositivity with atopy and wheezing/asthma in 791 elementary school students, 6–13 years old. Outcomes

n (%)/N

Adjusted OR (95% CI)a

Phadiatop* IgE Z 0.70 KU/L) B. tropicalis specific IgEZ 0.70 KU/L Any allergen IgE Z0.70 KU/L Atopic wheezing/asthma Non-atopic wheeezing/asthma

251(49.9)/503 286 (56.8)/503 342 (67.9)/503 398(79.2)/503 57(11.3)/503

1.95 (1.40–2.72) 1.85 (1.31–2.62) 2.00 (1.49–2.68) 1.04 (0.54–2.08) 1.08 (0.40–2.70)

a IgE specific to Blomia tropicalis (D201) and to Phadiatop aerollergens (pollen extracts, fungi extracts, dog and cat epithelia and Dermatophagoides spp.) measured by immunoCAP.

Fig. 2. Schematic representation of the steps involved during the study to achieve the results.


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163 performed to evaluate the levels of allergen-specific IgE and IgG anti-Toxocara spp. reactivity. Uni164 variable and multivariable analyses were used to analyze Toxocara spp. infection risk factors and the 165 association of this infection with atopy and asthma phenotypes. The variables investigated were: 166 gender, age, maternal schooling, income, school location, contact with dog and cat (Fig. 2). 167 168 169 Conflict of interest 170 171 The authors declare that they have no competing interests. 172 173 174 Acknowledgments 175 176 Q4 The authors would like to acknowledge FAPESB, Brazil, for financial support and technical support 177 Q5 to conduct this work. 178 179 180 Transparency document. Supplementary material 181 182 Transparency data associated with this article can be found in the online version at http://dx.doi. 183 org/10.1016/j.dib.2016.08.062. 184 185 186 References 187 188 [1] M.B. Silva, A.L. Amor, L.N. Santos, A.A. Galvão, A.V. Oviedo Vera, E.S. Silva, et al., Risk factors for Toxocara spp. seroprevalence and its association with atopy and asthma phenotypes in school-age children in a small town and semi-rural areas of 189 Northeast Brazil, Acta Trop. (2016). 190 [2] A. Strina, S. Cairncross, M.L. Barreto, C. Larrea, M.S. Prado, Childhood diarrhea and observed hygiene behavior in Salvador, 191 Brazil, Am. J. Epidemiol. (2003).
