Decision Support - Vanda, Healthcare Management Systems

Knowledge Base for Clinical

Decision Support

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With fresh, accurate information, have greater

confidence in making safe decisions

at every point of care.

About Us MIMS is a leading provider of business-to-business solutions that help companies worldwide meet their information needs. With more than 40 years in medical publishing and communication, MIMS is one of the world’s leading providers of drug information, educational content and marketing services to healthcare professionals, pharmaceutical industry, patients and consumers, through its well-established and renowned leading brands. MIMS’s range of innovative products and responsive services include: •

MIMS Drug Information System (MIMS, MIMS Annual, MIMS Specialty Editions)

•

MIMS Online (www.mims.com)

•

MIMS Gateway (Clinical reference solutions)

•

MIMS Integrated (Clinical decision support knowledge bases)

•

Professional Medical Publications and CME Journals (Medical Tribune, Oncology Tribune, Journal of Paediatrics, Obstetrics & Gynaecology, Pharmacy Today)

•

Integrated Marketing Solutions for medical professionals and patients

Through these, we reach healthcare professionals in Australia, New Zealand and Asia. Our focus on these communities are unparalleled. MIMS has an international presence in Singapore, China, Indonesia, Thailand, Korea, Hong Kong, Vietnam, Philippines, Malaysia, India, Australia and New Zealand.

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Integrated. Comprehensive. Current.

MIMS MIMS* has been the hallmark of drug information for over 40 years in Asia Pacific. An advanced Drug Information System, MIMS continues to evolve to meet the emerging requirements and needs of healthcare professionals. MIMS has developed tools and knowledge bases for integration into clinical applications for decision support, helping healthcare professionals make informed decisions at the point of care.

BE CONFIDENT AT WORK. Let MIMS - the local drug prescribing information you have trusted for over 40 years - work for you, in this new integrated, enhanced format!

DEPLOY THE SOLUTION THAT WORKS.

MIMS INTEGRATED provides essential clinical decision support to help optimise clinician’s time and improve the quality of patient care

MIMS has a presence in Asia, Australia and

MIMS INTEGRATED contains the MIMS drug database - the most up to date and comprehensive source of locally approved drug information, and the MIMS decision support modules which are internationally referenced and clinically reviewed.

healthcare solutions backed with international

New Zealand, bringing to you a unique Drug Information

System

that

embodies

local

expertise.

MIMS INTEGRATED provides real-time interactivity and intervention checks for doctors and pharmacists, improving medication management at the point of care. * Available in India as CIMS; in Korea as KIMS

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Better

Patient

Safety.

Why MIMS INTEGRATED •

MIMS INTEGRATED provides a comprehensive knowledge base of locally approved drug information powered with internationally referenced Clinical Decision Support tools.

•

MIMS INTEGRATED is embedded in the clinical application system, supplying up to date drug information and interacting intelligently with the patient’s profile to maximise healthcare professionals’ time.

•

MIMS INTEGRATED provides Clinical Decision Support knowledge bases to help healthcare professionals in electronic prescribing and dispensing environments make better-informed prescribing & therapeutic choices.

•

MIMS INTEGRATED enables healthcare professionals to improve the quality of patient care in the area of medication management.

•

MIMS INTEGRATED is a fully customisable drug database that can be mapped to any hospital formulary and integrated into a prescribing system to double up as the backbone of the inventory management process.

•

MIMS INTEGRATED Decision Support Modules are internationally referenced & clinically reviewed.

•

MIMS INTEGRATED is based on a modular architecture which comprises of the following modules:



✚ DrugInfo



✚ DrugAlert



✚ DrugAllergyAlert



✚ DrugHealthAlert



✚ DuplicateAlert



✚ DrugPregnancyAlert



✚ DrugLactationAlert



✚ DrugDoseAlert



Clinical Decision Support refers broadly to providing clinicians or patients with clinical knowledge and patient-related information, intelligently filtered or presented at appropriate times, to enhance patient care. Clinical knowledge of interest could range from simple facts and relationships to best practices for managing patients with specific disease states, new medical knowledge from clinical research and other types of information.



Clinical Decision Support goals and objectives are the target healthcare processes and outcomes that Clinical Decision Support efforts are intended to achieve. Goals are high-level or strategic targets such as increasing patient safety; objectives are more specific, tactical targets, such as increasing the use of specific life-saving medications in appropriate circumstances. Healthcare Information and Management Systems Society http://www.himss.org/ASP/topics_clinicalDecision.asp (April 2007)

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MIMS INTEGRATED adapts to your needs by

mapping to your formulary.

DrugInfo Module

The DrugInfo* module delivers timely and regularly updated prescribing information on pharmaceutical products. This module comprises of MIMS Essential Product Information linked to the MIMS Annual Full Product Information and independently compiled MIMS Generic Monographs.

Essential Product Information • Brand Name • Generic Name • MIMS Classification • Poison Class/Drug Schedule • Content/Active Ingredient • Indications • Dosage • Administration

• Contraindications • Special Precautions • Adverse Effects • Drug Interactions • Presentation, Pack And Price • Supplier’s Information • Pregnancy Category (US FDA)

Full Product Information • • • •

Brand Name Generic Name Content/Active Ingredient Description of Chemical & Physical Properties • Pharmacology, Pharmacokinetics, Toxicology • Indications • Dosage & Administration • Overdosage

• Contraindications • Warnings • Special Precautions • Adverse Effects • Side Effects • Drug Interactions • Caution for Usage • Storage • Presentation, Pack And Price • Supplier’s Information

Generic Monograph • • • • •

Generic Name MIMS Classification Mechanism of Action Dosage & Indications Dosage Adjustments for Special Population Groups • Administration

• Contraindications • Special Precautions • Adverse Effects • Drug Interactions • Food Interactions • Lab Interference • Pregnancy Category (US FDA)

* Exact content may vary from country to country.

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MIMS INTEGRATED

interacts intelligently in real time to maximise your time.

DrugAlert Module

The DrugAlert module processes drug-drug interaction checks. An interaction warning displays essential information after checking for an interaction between two drugs:

• •

Severity level of interaction Level of documentation to support the interaction

•

Description of probable mechanism of the interaction

•

Pharmacological action of each interacting drug

• •

Recommended action

Examples:

• • • • •

itraconazole + phenytoin warfarin + fenofibrate phenytoin + carbamazepine carbamazepine + chlorpromazine phenytoin + diazoxide

International references

A medication error is any preventable event that may cause or lead to inappropriate medication use or patient harm while the medication is in the control of the health care professional, patient, or consumer. Such events may be related to professional practice, health care products, procedures, and systems, including prescribing; order communication; product labeling, packaging, and nomenclature; compounding; dispensing; distribution; administration; education; monitoring; and use. National Coordinating Council for Medication Error Reporting and Prevention http://www.nccmerp.org/aboutMedErrors.html (April 2007)

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Reassuring. Fast.

DrugAllergyAlert Module

DrugHealthAlert Module

The DrugAllergyAlert module enables the healthcare professional to process drug allergy checks at the point of care by comparing a patient’s drug allergy profile and the current medication regime, against the active ingredients in the medications about to be ordered. An alert is displayed to warn against a potential drug allergy. Also, generates a cross-reaction warning for allergic cross-sensitivity between drug groups is provided with international references.

The DrugHealthAlert module is used in conjunction with the patient’s profile for stored medical conditions and subsequently for potential contraindications with the prescribed medication. The database currently supports ICD10 and can be cross-referenced to several standard disease classification systems worldwide. The alert returns information on the severity, the level of documentation and a description of the contraindication. All information is internationally referenced.

Examples:

Examples:

• • •

penicillins + cephalosporins heparinoids + heparins salicylates + tartrazines

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• • •

digoxin + sick sinus syndrome ciclosporin + melanoma ciclosporin + renal impairment

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Invest in tomorrow. Practise patient safety today.

DuplicateAlert Module The DuplicateAlert module provides an alert if the medicine to be prescribed, dispensed or administered has an identical therapeutic function to another medicine already prescribed to the patient. Examples:

•

omeprazole + ranitidine



■



omeprazole (proton pump inhibitors group) and ranitidine (H2 antagonists group) are both indicated for GI ulceration.

• Losec

®

+ Prevacid®

■

LOSEC® contains omeprazole and PREVACID® contains lansoprazole. Both are proton pump inhibitors.

DoseAlert Module

Alerts may also be triggered based on frequency, duration, age, gender, weight or body surface area (BSA). This helps the healthcare provider and, eventually, the patient to avoid treatment failures, adverse effects and toxicities that could be life-threatening. Key characteristics:

•

Data and information are obtained from recognised published medical literature or internationally accepted drug references.

•

Monthly updates are completed using leads from online tertiary references.

•

Applicable and can be used by related healthcare providers.

• •

Customisable user and alert interface.

•

Dose profiles may be brand, formulation or indication specific.

Dose profiles are available for combination products.

Examples: The DoseAlert module processes drug orders to check for patient suitability and for doses against recommended therapeutic ranges. The DoseAlert module warns healthcare providers if the drug being prescribed to a patient is outside of the normal dosing limits. Alerts may be triggered if the dose is sub-therapeutic (below the minimum dose) or an overdose (above the maximum and /or the absolute maximum).

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•

Indication based dosing: Finasteride + benign prostatic hyperplasia

• •

Weight based dosing: Abciximab

• •

Duration based dosing: Ofloxacin

Body surface area (BSA) based dosing: Oxaliplatin Gender based dosing: Bicalutamide contraindicated in female

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Safety is something we learn from the start -

Being isaccident free doing our part.

DrugPregnancyAlert Module

DrugLactationAlert Module

The DrugPregnancyAlert module cautions the healthcare providers if the drug being prescribed to a pregnant woman is harmful to the developing foetus. Pregnancy data is principally composed of pregnancy letter categories from the US Food and Drug Administration (FDA) and/ or the Australian Drug Evaluation Committee (ADEC); and may contain short comments based on literature review of current studies and guidelines. Drug safety data for women of childbearing age are also included to avoid inadvertent exposure of the foetus to an unsafe drug, especially in unplanned pregnancies.

The DrugLactationAlert module is a tool that alerts the healthcare provider if the medicine(s) to be prescribed or administered to a mother can inhibit lactation, cause harm to the nursing mother or child, or if the drug is indicated in conditions where lactation is a contraindication. A record in the DrugLactationAlert module contains a description on the excretion of the drug into breastmilk, the effect of the drug on either the nursing mother or infant, severity of the interaction, and the precautions needed. This helps the healthcare professional and, eventually, the nursing mother to avoid adverse events and toxicities that could be life-threatening to the infant.

Key characteristics:

•

Data on pregnancy letter categories are from official product information labels approved by the US FDA and/or ADEC.

•

Comments are evaluated information on drugs and pregnancy from recognised published medical literature or internationally accepted drug references.

•

Monthly updates are completed using leads from online tertiary references, and safety updates from the FDA and ADEC.

•

Pregnancy letter categories specific to the route of administration are included.

For drugs without assigned pregnancy letter categories, any available data from studies/ guidelines/recommendations is provided.

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Key characteristics:

•

Data and information are obtained only from recognised published medical literature or internationally accepted drug references, and not from the manufacturer’s prescribing information

•

Regular review and updating of information and evidence contained in the database is carried out to ensure that the information is up to date.

•

Alerts healthcare providers about the severity, references used and description of the interaction.

•

Both generic and brand names are recognised.

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Integrated.. Intelligent. Intuitive.

MIMS INTEGRATED API MIMS INTEGRATED is delivered via the FastTrack software Application Programming Interface (API). By utilising a software API the data content and decision support modules can be quickly integrated into the clinical application system. Development and testing time are reduced allowing for fast deployment to the end user. FastTrack is implemented as an XML based API which allows for a great deal of flexibility in the integration and presentation of the data within the clinical application. Functionality is provided to allow access to the DrugInfo module as well as to support the interactive modules such as DrugAlert and DrugAllergyAlert.

•

FastTrack Windows for Microsoft Windows



FastTrack Windows has an extremely small footprint and has no dependency on any other library files (DLL file). Data is stored in a proprietary database engine requiring no administration. The API is accessed through a Microsoft COM interface which is compatible with the Microsoft .Net environment..

• FastTrack Java

FastTrack Java requires J2SE 1.4 or above and users an embedded database, which requires no administration.

• FastTrack Linux

Built for speed and ease of deployment, the FastTrack API has been designed to be the most convenient way to deploy MIMS knowledge into your application. FastTrack is available in three versions for different platforms:

FastTrack Linux requires a recent version of Linux using x86 or x86_64 architectures. Languages supported: C++; Java 6/7; PHP 5.3/5.4 (available but not tested). Library dependencies (important): g++ 4.3 and glibc 2.1. The Linux API has been tested on Ubuntu 11 and 12, SuSE Enterprise Linux 11 SP2, SuSE Enterprise Linux 12.

Server Requirement for Windows, Java & Linux Versions Minimum

Recommended

CPU Intel® Core2 Duo 1.7GHz

CPU Intel® i5 2.53GHz

RAM

2 GB

RAM

4 GB

HDD free space

4 GB

HDD free space

5 GB

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Offices in Asia Pacific AUSTRALIA Level 2, 1 Chandos Street St Leonards NS W 2065 Australia Tel: (61) 2 9902 7700 Fax (61) 2 9902 7701 [email protected]

CHINA Beijing

Suite 907 A19 North East Third Ring Road Nexus Center Chaoyang Beijing 100020 Tel: (86 10) 5970 6111 Fax: (86 10) 5970 6112 [email protected]

Shanghai

Delhi - NCR

404, 4th Floor, Galleria Tower, DLF City Phase-IV, Gurgaon-122009 Haryana, India Phone: (91 124) 463 6500 Fax: (91 124) 463 6522 [email protected]

Mumbai

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INDONESIA

SINGAPORE

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Zhuhai

KOREA

THAILAND

Room 1506B, Industry and Commerce Mansion, No.125 East Ren Min Road, Xiang Zhou District, Zhuhai 519001, China Tel: (86 756) 811 6841 Fax: (86 756) 811 6842 [email protected]

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INDIA Bangalore

Empire Towers, No. 53, Railway Parallel Road, Kumara Park West, Bangalore 560020, Karnataka, India Tel: (91 80) 4346 4500 Fax: (91 80) 4346 4529 [email protected]

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12FL. Sangkyoung Bldg., 120 Teheran-ro, Gangnam-gu Seoul 135-934, Korea Tel: (82 2) 3019 9350 Fax: (82 2) 3454 0149 [email protected]

MALAYSIA

Level 3A, Luther Centre, No. 6, Jalan Utara, 46200 Petaling Jaya, Selangor, Malaysia Tel: (60 3) 7954 2910 Fax: (60 3) 7958 7853 [email protected]

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MYANMAR

Room-004, Building 1 Aung Myay Tharsi Housing Est (West) , Kamayut Township, Yangon, Myanmar Tel/Fax: (95-1) 539 174 [email protected]

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JUN-13

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