Deposits of terminal complement complex (TCC) - Gut
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Deposits of terminal complement complex (TCC) - Gut
ment complex (TCC) is formed when C5b reacts with. C6, C7, C8, and C9. ..... complex disease or Arthus type reactionas suggested by the presence of ...
(Gut, 1989, 30, 36 1-366
Deposits of terminal complement complex (TCC) in muscularis mucosae and submucosal vessels in ulcerative colitis and Crohn's disease of the colon T S HALSTENSEN, T E MOLLNES,
FAUSA AND P BRANDTZAEG
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From the Laboratory for Immunohistochemistry and Immunopathology (LIIPA T), Institute of Pathology, Institute of Immunology and Rheumatology, and Section of Gastroenterology, Medical Department A, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway
Extensively washed, ethanol fixed and paraffin embedded colonic specimens from 15 patients with ulcerative colitis (UC) and nine patients with Crohn's disease (CD) of the colon, ileal specimens from six patients with CD of the ileum, and histologically normal control specimens obtained from 10 patients operated for colonic carcinoma, were examined by immunohistochemistry with a monoclonal antibody specific for a neoepitope in the C9 part of the terminal complement complex (TCC). The submucosal blood vessels in inflammatory bowel disease (IBD) showed significantly more TCC positivity than the controls, and vascular TCC deposition was statistically related (p
