Design of dissolution media for in-vitro bioequivalence testing of ...
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Design of dissolution media for in-vitro bioequivalence testing of ...
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Journal of Applied Pharmaceutical Science Vol. 3 (06), pp. 106-110, June, 2013 Available online at http://www.japsonline.com DOI: 10.7324/JAPS.2013.3617 ISSN 2231-3354
Design of dissolution media for in-vitro bioequivalence testing of Lamivudine Nagiat T Hwisa1, Shanta Kumari Adiki2, Prakash Katakam1*, Babu Rao Chandu 1 1
Faculty of Pharmacy, University of Zawia, Al-Zawia, Libya. Nirmala College of Pharmacy, Mangalagiri, Guntur 522503, India.
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ARTICLE INFO
ABSTRACT
Article history: Received on: 31/03/2013 Revised on: `13/05/2013 Accepted on: 06/06/2013 Available online: 27/06/2013
The present investigation is aimed at developing the stability indicating dissolution media for the determination of lamivudine (3TC) in pharmaceutical dosage forms. The stability of 3TC was tested in various dissolution media maintained at ambient temperature and 37 oC for 48 hrs. Stability studies of 3TC in various media indicated that the drug was stable in 0.1M HCl, pH 1.2 KCl-HCl buffer, pH 6.2 and pH 7.0 phosphate buffers. The λmax were found to be 280.0, 278.8, 273.0 and 271.5nm for 0.1M HCl, pH 1.2 KCl-HCl buffer, pH 6.2 and pH 7.0 phosphate buffers respectively with low CV of
