The majority of the observed variants are within CYP2A7, which is a Leucine instead of Arginine in nearly half of all alleles, though there are rarer variants in ...
Feb 7, 2017 - CJ, MSA, LVW and MDT ... ticularly smoking, impact lung function, genetic .... Data on age and smoking were checked for consistency over.
Results: From 351 frugivorous bats, we detected 14 coronaviruses from two ... evaluate spillover risk to human populations especially for individuals that hunt and consume infected bats. ... HCoV-229E and HCoV-OC43 which generally cause.
Apr 15, 2016 - Milk Genomics initiative,â supported by the Danish Council for Strategic Research, the Danish Cattle Federation, and Arla. Foods as well as the ...
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA. 2 ..... Hoxa13, Pbx- .... for genotype calling and QC using the GenCall algorithm.
Apr 26, 2018 - ACKNOWLEDGMENTS. We thank Daniel Weingaertner and the Department of. Informatics from the Federal University of Paraná in Brazil,.
*The genetic scores were weighted by the individual per allele effects of rs12785878, rs10741657, rs6013897 and rs2282679 on 25(OH)D concentration in CKB ...
We have also designed dynamic HTML web ...... available with Internet Explorer 8 due to the lack of HTML5. ... convert SNPs to dbSNP 132 automatically. 4.
... MICHEL SIXOU,4 MARIE-ANDREE SOL,§. ROBERT HARMON, AND TERRY L. McKAY ...... Yates, F. 1934. The analysis of multiple classifications with ...
Cooper, R., Ward, R., Lander, E.S., Daly, M.J., Altshuler, D., 2002. The structure of hap- · lotype blocks in the human genome. Science 296, 2225â2229.
Jun 6, 2016 - known before planning any medical act or follow-up. .... For instance, the neutral I1858L mutation displays a median of cells per colony higher ...
May 18, 2016 - A Dessa Sadovnick, PhD*,â , Anthony L Traboulsee, MDâ , Cecily Q Bernales, BSc*, Jay P Ross,. BSc*, Amanda L Forwell, BSc*, Irene M Yee, ...
Somaclonal variation occurs in plants regen- erated from somatic tissues and has been observed for morphological, physiological, biochemical and genetic ...
Sep 20, 2018 - advent and improvement of next-generation sequencing technology, has ...... sequencing: advances and applications in cancer diagnosis.
Paterson J, Pichert G, Porteous M, Rahman N, Rogers M, Rowe S, Shanley ... Grarup N, Rose CS, Andersson EA, Andersen G, Nielsen AL, Albrechtsen A,.
Feb 9, 2016 - showed that RTL was significantly associated with SCCHN risk ..... program based on community for non-infective diseases in Jiangsu, China.
Red hair color is associated with phaeomelanin [8]. There is a good dependency of pigmentation characteristics with the. MC1R variants. There are several ...
enzyme at 958C for 15 min and then 40 cycles of denaturation ...... Cornelia Silaghi, Jasmin Skuballa, Claudia Thiel, Kurt Pfister, Trevor Petney, Miriam Pfäffle, ...
Nine associations were novel: IL18: BIRC6, RAD17,. MARVELD2; ferritin: F5; IGF binding protein 1: SERPING1, KLKB, GCKR, CELSR2, and heat shock. 70-kDa ...
Aug 20, 2014 - randomly selected pairs of transcripts from the genes hosting detected sQTLs, and .... unlimited but, we have simulated four main scenarios, which we believe describe ...... www.ebi.ac.uk/Tools/geuvadis-das. Sharing of sQTLs ...
Jun 25, 2005 - A. phagocytophilum, or the WTD agent in Georgia were pre- viously reported (3 ... Sumner, J. A. Comer, R. S. Buller, and G. A. Storch. 2003.
Minor allele frequency (MAF) of 0.001 was used to define variants as rare or common. ... variants were common (MAF ⥠0.001) in at least one ethnic gnomAD ...
The NOD2 gene variants R702W (rs2066844), G908R (rs2066845) and 1007fs (rs2066847) were analyzed by TaqMan PCR as described previously8. For all ...
Since Pro is a helix breaker [133], the substitution of proline for leucine, a ...... [138] Huber, R.; Carrell, R. W. Implications of the three dimensional. Structure of αl ...
Eduardo Beleza Yamagishi2, Tatiane Cristina Seleguim Chud2, Alexandre. Rodrigues Caetano3, DanÃsio Prado Munari2, Dorian J. Garrick4, Marco Antonio.
X-meeting • November 2016 • UFMG
Detection of potential genetic variants affecting gene function in Guzerat cattle Adhemar Zerlotini1, Nedenia Bonvino Stafuzza2, Francisco Pereira Lobo1, Michel Eduardo Beleza Yamagishi2, Tatiane Cristina Seleguim Chud2, Alexandre Rodrigues Caetano3, Danísio Prado Munari2, Dorian J. Garrick4, Marco Antonio Machado5, Marta Fonseca Martins5, Maria Raquel Carvalho6, Marcos Vinicius Gualberto Barbosa da Silva5 1Embrapa
Informática Agropecuária, Campinas; 2Departamento de Ciências Exatas, Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias; 3Embrapa Recursos Genéticos e Biotecnologia; 4Department of Animal Science, Iowa State University; 5Embrapa Gado de Leite; 6Universidade Federal de Minas Gerais. Guzerat is a dual-purpose breed recognized for important traits to its adaptation to adverse tropical environments such as resistance to parasites, heat tolerance and ability to intake forage with low nutritional value. Once genetic variation responsible for these traits has so far not been well characterized, the aim of this study was to identity single nucleotide variants (SNVs) and insertion/deletions (Indels) in Guzerat cattle breed from whole genome re-sequencing in order to characterize loss-of-function variants which could be associated with complex traits in this cattle breed. The genetic variants identified using HiSeq 2000 sequencing platform were classified using the Ensembl Variant Effect Predictor (VEP) tool, based on a subjective classification of the severity of the variant consequence in transcripts defined by the Sequence Ontology (high, moderate, low or modifier). The DAVID v6.7 tool was used for functional enrichment analysis using the list of genes predicted to be function or activity potentially affected by genetic variation (high and moderate effect) against the background set of bovine genes. The Gene Ontology (GO) enrichment analysis were performed considering 5% FDR threshold for significance. The KEGG pathway database was used to investigate the enriched metabolic pathways (P
