RESULTS: For all ages and for normal and poor responders combined the clinical PR/transfer was 33.4% (248/743) for women receiving all FSH for. COH vs.
RESULTS: For all ages and for normal and poor responders combined the clinical PR/transfer was 33.4% (248/743) for women receiving all FSH for COH vs. 39.7% (423/1066) when LH was added (P¼.007). The viable PRs were 28.3% vs. 35.5% (P¼0.0016) and the live delivered PRs were 25.8% vs. 32.3% (P¼0.0038). Evaluating separately the poor responders, the clinical, viable, and live delivered PRs for the all FSH group was 25.5% (103/404), 20.5% (83/404), and 17.8% (72/404) vs. 26.4% (60/ 227), 22.5% (51/227), and 20.3% (16/227) for LH/FSH group (chi-square analysis, P¼NS). CONCLUSION: Addition of LH to FSH improves pregnancy rates in normal responders using a traditional high dose FSH COH protocol with a GnRH antagonist. Using mild stimulation for women with diminished ovarian reserve adding LH does not seem to matter.
P-527 Wednesday, October 19, 2011 IVF OUTCOMES FOLLOWING GNRH AGONIST FLARE AND GNRH ANTAGONIST STIMULATION PROTOCOLS IN YOUNG LOW RESPONDERS UNDERGOING THEIR FIRST IVF CYCLE. A. N. Imudia, S. T. McLellan, C. Veiga, D. L. Wright, T. L. Toth, A. K. Styer. Massachusetts General Hospital Fertility Center, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital/Harvard Medical School, Boston, MA. OBJECTIVE: To investigate if a specific low responder controlled ovarian hyperstimulation (COH) protocol results in superior pregnancy outcomes in anticipated low responder women of favorable age groups (< 38 yo) during first fresh IVF attempt. DESIGN: Retrospective cohort study in a tertiary academic center. MATERIALS AND METHODS: A total of 1164 consecutive IVF cycles were reviewed from Jan 05 - Dec 10. All 322 initial fresh IVF attempts utilizing low responder protocol [GnRH antagonist (ANT) or GnRH agonist flare (FL)] were reviewed. Low responders were defined by ovarian reserve testing (Basal FSH and AFC) and protocols chosen by the patient’s physician. Patient demographics, IVF cycle characteristics, and pregnancy outcomes of both groups were analyzed using SPSS. RESULTS: Two hundred seventy-two IVF cycles were analyzed according to inclusion criteria [ANT-N ¼ 146 (53.7%); FL-N ¼ 126 (46.3%)] and 85.7% of the cycles went to ET (ANT ¼ 89.7 and FL ¼ 81.0%). Respective demographic characteristics including mean age, BMI, number of prior superovulation/intrauterine inseminations, gravidity, and parity were similar between both groups. The AFC was higher (7.06 2.36 vs. 8.87 3.15, P
