Differentially expressed lncRNAs and mRNAs ... - Wiley Online Library
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Differentially expressed lncRNAs and mRNAs ... - Wiley Online Library
Pediatric Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China 2
The Second General Surgery, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, Shijiazhuang, Hebei, China 3
Research Center, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, Shijiazhuang, Hebei, China Correspondence: Gui-ying Wang, The Second General Surgery, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, Hebei 050011, China (wangguiyingtgzy@163. com). Funding information National Natural Science Foundation of China, Grant/Award Number: 81502032; Natural Science Foundation of Hebei Province, Grant/Award Number: H2015206376; Health and Family Planning Commission of Hebei Province, Grant/ Award Number: 20150362; 2016 Hebei government-supported clinical medical talents; 2016 Hebei medical application technology tracking project, Grant/Award Number: GL201621
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Abstract Long noncoding RNAs (lncRNAs) play an important role in gene regulation, but their impact on the pathogenesis of colorectal cancer and the biological function of cancer cells is unclear. In this study, we used next-generation sequencing to study the differences in the expression profiles of lncRNAs and mRNAs in colorectal cancer tissues. We analyzed the differentially expressed genes by Gene Ontology/Kyoto Encyclopedia of Genes and Genomes (GO/KEGG) enrichment and predicted new lncRNA functions. Our results revealed that compared with lncRNAs and mRNAs in nontumor colorectal tissues, 1019 lncRNAs (512 upregulated, 507 downregulated) and 3221 mRNAs (1606 upregulated, 1615 downregulated) were differentially expressed in tumor colorectal tissues (fold change >2 and P
