Amino acids. U 0400. Direct Synthesis of Unprotected Phenols Using Palladium-Catalyzed Cross Cou- pling Reactions of Functionalized Organozinc Reagents.
2004
Amino acids
Amino acids U 0400 Direct Synthesis of Unprotected Phenols Using Palladium-Catalyzed Cross CouReactions of Functionalized Organozinc Reagents. — The palladium-cata22- 193 pling lyzed cross coupling of various amino acid-derived organozinc reagents (I) and (IV) with iodophenols (II) can be carried out without protection of the hydroxy group. Even iodoarene containing a benzylic alcohol can be applied although moderate yield is obtained only [cf. (IIIe)]. — (JACKSON*, R. F. W.; RILATT, I.; MURRAY, P. J.; Org. Biomol. Chem. 2 (2004) 1, 110-113; Dep. Chem., Univ. Sheffield, Sheffield S3 7HF, UK; Eng.) — Mischke
