Transient electronics or Bioresorbable ... A Conformal, Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac ... Environmental sensors & e- waste. 32 ...
Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics Dawn John Mullassery Electrical and Computer Engineering University of British Columbia 1
The Paper
John A Rogers
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Overview • Motivation and Background • The technology • Future
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MOORE’s LAW “The observation made in 1965 by Gordon Moore, co-founder of Intel, that the number of transistors per square inch on integrated circuits had doubled every year since the integrated circuit was invented. Moore predicted that this trend would continue for the foreseeable future.” - Webopedia
http://www.singularitysymposium.com/moores-law.html
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Bio-Integration
6th International Conference on Intelligent and Advanced Systems 2016 (ICIAS2016), ieeemy.org, http://www.computerhope.com/jargon/e/edsac.htm,
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Bio-Integration
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Existing Technology – Utah
http://www.sci.utah.edu/~gk/abstracts/bisti03/, 7 Acute human brain responses to intracortical microelectrode arrays: challenges and future prospects - Eduardo et.al , doi: 10.3389/fneng.2014.00024
Electro - Corticography
Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical Mapping N. Jeremy Hill et.al ; doi: 10.3791/3993
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Two main areas! • Bio-integrated or Biocompatible electronics • Transient electronics or Bioresorbable electronics
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Bio-Integrated Electronics • Epidermal Electronics
• Non – uniform surfaces inside the body 10
Bio-Integrated Electronics - Brain
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Bio-Integrated Electronics - Brain
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13 http://rogers.matse.illinois.edu/multimedia.php
Bio-Integrated Electronics - Cardiac Electrophysiology
A Conformal, Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology: Jonathan Viventi, et.,al; Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo: Jonathan Viventi, et.al;
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Bio-Integrated Electronics - Cardiac Electrophysiology
A Conformal, Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology: Jonathan Viventi, et.,al;
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16 http://rogers.matse.illinois.edu/multimedia.php
Bio-Integrated Electronics Spatiotemporal cardiac measurements
ECG sensor
Si strain gauge μ-ILED
pH sensor
Temperature sensor
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium. Lizhi Xu et.al;
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Bio-Integrated Electronics - Advantages • High resolution results • Less complicated process • Similar process can be used for epidermal electronics • Non – invasive method
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Transient Electronics Electronic systems that dissolve, resorb, or otherwise physically disappear at programmed rates or specific triggered times.
A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
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Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
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Water Soluble Silicon Silicon for Transient Electronics
Silicon for Regular Electronics
• Silicon Thickness - 35 nm
• Silicon Thickness 700 µm
• Dissolution Time – 10 days
• Dissolution Time – 600 to 1000 years
• Water – 0.4 ml
• Water - 8 L
A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
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Silk membranes dissolve
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Transient Electronic Device
23 A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
24 A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
25 A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
26 A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
Why a novel approach? • Biomedical Purposes • Environmental Sensors • Consumer Electronics
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Biomedical Application – Transient Electronics
28 A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
Biomedical Application – Surgical Site Infections
29 A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
Edible and Good! Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 µg vs ~ 10 mg
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Biomedical Applications • Drug Delivery
• Electronic Aspirin
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Environmental sensors & e- waste
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33 http://rogers.matse.illinois.edu/multimedia.php
Next Few Years & Future • Human body • Non – biomedical applications • Further R & D required
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Why will this be a classic paper? • New approach to existing techniques of biomedical methods • Any form of biological surface – with minimal invasion • Not limited to biomedical
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