'JM Brag-*. 'Pancreato-Biliary Service, and 'Vascular. Biology Group, Royal Infirmary, Manchester, UK; 'Surgical. Pathophysiology, University Hospitals, Malmo, ...
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Biochemical Society Transactions (1999) 27
Relationship between Trypsinogen Burden, Activation and Fibrinol sis in Acute Pancreatitis. 2J Douglas, Appelros, 'A Borgstrom, ;=: : I ' 'JM Brag-*. 'Pancreato-Biliary Service, and 'Vascular Biology Group, Royal Infirmary, Manchester, UK; 'Surgical Pathophysiology, University Hospitals, Malmo, Sweden; 4Chris Hani Baragwanath Hospital, South Africa
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Heightened fibrinolysis is known to be associated with increased morbidity in acute pancreatitis, but its relationship to the degree of trypsinogen activation is unclear. We report a study of admission blood and urine samples, using surrogate markers of plasmin (plasma cross-linked fibrin degradation products; XL-FDP), thrombin (plasma soluble fibrin; SF) and trypsinogen activation (urinary procarboxypeptidase B activation peptide; CAPAP), with assessment of total trypsinogen burden (t-Tg), including anionic and cationic isoforms, in serum. 24 consecutive African patients were studied, including 7 with a severe outcome (3 deaths, 2 at day 2; and 4 with acute lung injury with or without acute tubular necrosis) and 17 mild outcomes. SF mg/L
t-Tg pg/L (n3 (1 7) (1 7) (23) [Reference] (26. IO-IOO] [O 98. 0 30-4 51 [57, 39-92] MildAP '333, I 6, * 1892, 0 40-7 8 144-3664 56-1126 Severe AP * t 1200, 'tS 0, *t4775, 3 8-10 2868-8615 476-2000 Significance 2pC0.05; 'different from controls; ?different from XL-FDP pg/L
CAPAPnM
(22)
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