DNA damage and alterations in expression of DNA damage ...

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regulated DNA damage responsive genes, the cyclin- dependent ... Particle size distribution of TiO2 NPs in the treat- ..... concentration of the small particles.
Nanotoxicology, 2010; Early Online, 1–13

DNA damage and alterations in expression of DNA damage responsive genes induced by TiO2 nanoparticles in human hepatoma HepG2 cells  1, BOJANA ŽEGURA1, MAGDALENA STEVANOVIC  2, JANA PETKOVIC  2, SAŠA NOVAK3, & METKA FILIPIC 1 NATAŠA DRNOVŠEK3, DRAGAN USKOKOVIC Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia, 2Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, Belgrade, Serbia, and 3Department for Nanostructured Materials, Jozef Stefan Institute, Jamova 39, Ljubljana, Slovenia

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(Received 3 March 2010; accepted 6 July 2010)

Abstract We investigated the genotoxic responses to two types of TiO2 nanoparticles (