Does MHC polymorphism explain phytohaemaglutinin-induced skin inflammation in the California sea lion? Jorge Montano 1 * , Camila Vera Massieu 1 , Karina Acevedo-Whitehouse
1,2
1 Laboratorio de Genética Molecular y Ecología Evolutiva. Unidad de Microbiología Básica y Aplicada, Facultad de Ciencias Naturales , Universidad Autónoma de Querétaro , Querétaro, 76140, México . *
[email protected] 2 Institute of Zoology, Regent ´s Park. London NW14RY, UK
Introduction The phytohaemagglutinin (PHA)-induced skin swelling test consists in a plant lectin often used as an in vivo challenge in studies on field immunology (1). Subcutaneous injection of PHA leads to local swelling that involves proliferation and infiltration of most leukocyte types into the challenged tissue because is recognized as a pathogen-associated molecular pattern (PAMP) (2). The Major Histocompatibility glycoproteins pathogen
and
Complex
involved
in
(MHC) the
class
II
presentation
nonpathogen-derived
genes of
peptides,
encode
foreign and
also
cell
antigens,
surface be
participate
these in
the
Results Model 1
df Deviance df Resid.
Resid. Dev
Pr(
