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Cell Reports, Volume 15
Supplemental Information
Dopamine Autoreceptor Regulation of a Hypothalamic Dopaminergic Network Stefanos Stagkourakis, Hoseok Kim, David J. Lyons, and Christian Broberger
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SUPPLEMENTAL INFORMATION
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Figure S1. Robustness of the TIDA oscillation and maintenance of rhythmicity in long whole-cell recordings, see Experimental Procedures.
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(Aa-g) Cycle duration does not change in control long-term recordings (+0.71±0.55 s; p>0.05 at t=40 min vs t=1 min; n=6). (Ag) Cycle duration does not change in control long-term recordings in an 80 min period (+0.97±1.03 s; p>0.05 at t=80 min vs t=1 min; n=3).
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Figure S2. Related to Figure 1; D2R activation effect on cycle and phase duration persists in fast ionotropic blockade.
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(A) Quinpirole application leads to an increase in cycle duration in the presence of fast ionotropic blockade (FIB;
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Picrotoxin 100 μM, CNQX 10 μM and AP-5 25 μM) via phase 1 and phase 3 prolongation. (B) Cycle duration
