being post mortem specimens, SM by biopsy in 8; and su.~ected SM in. 15. In the anaphylaxis group, 5 had G5 tryptase levels
J ALLERGYCLIN IMMUNOL
Abstracts
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VOLUME 97, NUMBER 1, PART 3
345
Serum cc-Tryptase, an Update On Its Use to Screen for
347
S y s t e m i c M a s t o c y t o s i s . K Carins MD. C Abernathv MS. LB f~'~7.,.b~.~ Richmond, VA Tryptase, a man cell mediator, is measured in serum samples received in our diagnostic immunology lab by two distinct assays. In normals, trypt&~e (ng/ml) measured by the G5 RIA (J tram Met 86:39,1991) detects primarily ~-tryptase and are 20 nghnl) in most cases of biopsy proven systemic masto~tosis (SM) (Schwartz et al, J Clin Inv, in press). Consecutive cases (n---41)were reviewed solely because the tryptsse level was markedly higher by the BI2 ELISA (>20) than by the (35 RIA (
