Mar 1, 2009 - Introducing Nanochemoprevention as a Novel Approach for Cancer. Control: Proof of Principle with Green Tea Polyphenol.
Cancer Research
A Journal AmericanAssociation Association for Research A Journal of of thethe American forCancer Cancer Research Volume 69 • Number 5 Reviews Mdm2 Affects Genome Stability Independent of p53. Alyssa Bouska and Christine M. Eischen........................................................................1697 The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer. Tao Liu, Pei Y. Liu, and Glenn M. Marshall ..............................1702
Priority Reports Silencing of TMS1/ASC Promotes Resistance to Anoikis in Breast Epithelial Cells. Melissa J. Parsons, Pritty Patel, Daniel J. Brat, Laronna Colbert, and Paula M. Vertino..................................................1706 Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate. Imtiaz A. Siddiqui, Vaqar M. Adhami, Dhruba J. Bharali, Bilal B. Hafeez, Mohammad Asim, Sabih I. Khwaja, Nihal Ahmad, Huadong Cui, Shaker A. Mousa, and Hasan Mukhtar....1712 Neuronal Guidance Protein Netrin-1 Induces Differentiation in Human Embryonal Carcinoma Cells. Mario Mancino, Claudia Esposito, Kazuhide Watanabe, Tadahiro Nagaoka, Monica Gonzales, Caterina Bianco, Nicola Normanno, David S. Salomon, and Luigi Strizzi......................................................................................1717 The Tamoxifen Metabolite, Endoxifen, Is a Potent Antiestrogen that Targets Estrogen Receptor ␣ for Degradation in Breast Cancer Cells. Xianglin Wu, John R. Hawse, Malayannan Subramaniam, Matthew P. Goetz, James N. Ingle, and Thomas C. Spelsberg ................1722 Oral Cancer Diagnosis by Mechanical Phenotyping. Torsten W. Remmerbach, Falk Wottawah, Julia Dietrich, Bryan Lincoln, Christian Wittekind, and Jochen Guck ..................................................1728 Depletion of Cytosolic Phospholipase A2 in Bone Marrow–Derived Macrophages Protects against Lung Cancer Progression and Metastasis. Mary C.M. Weiser-Evans, Xue-Qing Wang, Jay Amin, Vicki Van Putten, Rashmi Choudhary, Robert A. Winn, Robert Scheinman, Peter Simpson, Mark W. Geraci, and Raphael A. Nemenoff ..................1733
March 1, 2009 • Pages 1697–2150 Inactivation of the Nijmegen Breakage Syndrome Gene Leads to Excess Centrosome Duplication via the ATR/BRCA1 Pathway. Mikio Shimada, Ruri Sagae, Junya Kobayashi, Toshiyuki Habu, and Kenshi Komatsu...............................................................................1768 Identification of Cancer Stem Cells in Ewing’s Sarcoma. Mario-Luca Suvà, Nicolò Riggi, Jean-Christophe Stehle, Karine Baumer, Stéphane Tercier, Jean-Marc Joseph, Domizio Suvà, Virginie Clément, Paolo Provero, Luisa Cironi, Maria-Chiara Osterheld, Louis Guillou, and Ivan Stamenkovic.............................................................................1776 cIAP1, cIAP2, and XIAP Act Cooperatively via Nonredundant Pathways to Regulate Genotoxic Stress–Induced Nuclear Factor-B Activation. Hyung-Seung Jin, Dong-Hee Lee, Dong-Hwan Kim, Ji-Hye Chung, Seul-Ji Lee, and Tae H. Lee ..............................................1782 Overexpression of the Cellular DEK Protein Promotes Epithelial Transformation In vitro and In vivo. Trisha M. Wise-Draper, Rachael A. Mintz-Cole, Teresa A. Morris, David S. Simpson, Kathryn A. Wikenheiser-Brokamp, Mark A. Currier, Timothy P. Cripe, Gerard C. Grosveld, and Susanne I. Wells ..............................................1792 E2F7 Can Regulate Proliferation, Differentiation, and Apoptotic Responses in Human Keratinocytes: Implications for Cutaneous Squamous Cell Carcinoma Formation. Liliana Endo-Munoz, Alison Dahler, Ngari Teakle, Danny Rickwood, Mehlika Hazar-Rethinam, Ibtissam Abdul-Jabbar, Scott Sommerville, Ian Dickinson, Pritinder Kaur, Sophie Paquet-Fifield, and Nicholas Saunders.......................................1800 DDB1-CUL4 and MLL1 Mediate Oncogene-Induced p16INK4a Activation. Yojiro Kotake, Yaxue Zeng, and Yue Xiong ........................1809 Rat Umbilical Cord Stem Cells Completely Abolish Rat Mammary Carcinomas with No Evidence of Metastasis or Recurrence 100 Days Post–Tumor Cell Inoculation. Chanran Ganta, Doi Chiyo, Rie Ayuzawa, Rajashekar Rachakatla, Marla Pyle, Gordon Andrews, Mark Weiss, Masaaki Tamura, and Deryl Troyer ........................................................1815 TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2. Jeremy Copp, Gerard Manning, and Tony Hunter .............1821
Cell, Tumor, and Stem Cell Biology Conserved Gene Expression Programs Integrate Mammalian Prostate Development and Tumorigenesis. Colin Pritchard, Brig Mecham, Ruth Dumpit, Ilsa Coleman, Madhuchhanda Bhattacharjee, Qian Chen, Robert A. Sikes, and Peter S. Nelson ..........................................................1739 RASSF1A Mediates p21Cip1/Waf1-Dependent Cell Cycle Arrest and Senescence through Modulation of the Raf-MEK-ERK Pathway and Inhibition of Akt. Sonja Thaler, Patricia S. Hähnel, Arno Schad, Reinhard Dammann, and Martin Schuler..............................................1748 Structure-Function Approach Identifies a COOH-Terminal Domain That Mediates Heparanase Signaling. Liat Fux, Nir Feibish, Victoria Cohen-Kaplan, Svetlana Gingis-Velitski, Sari Feld, Chen Geffen, Israel Vlodavsky, and Neta Ilan...............................................................1758
Hepatocyte Growth Factor Activator Inhibitor Type 1 Regulates Epithelial to Mesenchymal Transition through Membrane-Bound Serine Proteinases. Haixia Cheng, Tsuyoshi Fukushima, Nobuyasu Takahashi, Hiroyuki Tanaka, and Hiroaki Kataoka..............1828 Control of HIF-1␣ Expression by eIF2␣ Phosphorylation–Mediated Translational Repression. Keyi Zhu, WaiKin Chan, John Heymach, Miles Wilkinson, and David J. McConkey ..............................................1836 HMGA Proteins Up-regulate CCNB2 Gene in Mouse and Human Pituitary Adenomas. Ivana De Martino, Rosa Visone, Anne Wierinckx, Dario Palmieri, Angelo Ferraro, Paolo Cappabianca, Gennaro Chiappetta, Floriana Forzati, Gaetano Lombardi, Annamaria Colao, Jacqueline Trouillas, Monica Fedele, and Alfredo Fusco .......................1844
Contents (Continued) Clinical Research PIK3CA Mutations in Colorectal Cancer Are Associated with Clinical Resistance to EGFR-Targeted Monoclonal Antibodies. Andrea Sartore-Bianchi, Miriam Martini, Francesca Molinari, Silvio Veronese, Michele Nichelatti, Salvatore Artale, Federica Di Nicolantonio, Piercarlo Saletti, Sara De Dosso, Luca Mazzucchelli, Milo Frattini, Salvatore Siena, and Alberto Bardelli .....................................................................................1851
Endocrinology Recapitulation of Pancreatic Neuroendocrine Tumors in Human Multiple Endocrine Neoplasia Type I Syndrome via Pdx1-Directed Inactivation of Men1. H.-C. Jennifer Shen, Mei He, Anathea Powell, Asha Adem, Dominique Lorang, Charles Heller, Amelia C. Grover, Kris Ylaya, Stephen M. Hewitt, Stephen J. Marx, Allen M. Spiegel, and Steven K. Libutti ..............................................................................1858 The -Catenin Axis Integrates Multiple Signals Downstream from RET/Papillary Thyroid Carcinoma Leading to Cell Proliferation. Maria Domenica Castellone, Valentina De Falco, Deva Magendra Rao, Roberto Bellelli, Magesh Muthu, Fulvio Basolo, Alfredo Fusco, J. Silvio Gutkind, and Massimo Santoro .................................................1867
Epidemiology Xenobiotic Metabolizing Gene Variants, Dietary Heterocyclic Amine Intake, and Risk of Prostate Cancer. Stella Koutros, Sonja I. Berndt, Rashmi Sinha, Xiaomei Ma, Nilanjan Chatterjee, Michael C.R. Alavanja, Tongzhang Zheng, Wen-Yi Huang, Richard B. Hayes, and Amanda J. Cross .................................................1877 Polymorphisms in the Vitamin D Receptor and Risk of Ovarian Cancer in Four Studies. Shelley S. Tworoger, Margaret A. Gate, I-Min Lee, Julie E. Buring, Linda Titus-Ernstoff, Daniel Cramer, and Susan E. Hankinson ..............................................................................1885 Functional Significance of UDP-Glucuronosyltransferase Variants in the Metabolism of Active Tamoxifen Metabolites. Andrea S. Blevins-Primeau, Dongxiao Sun, Gang Chen, Arun K. Sharma, Carla J. Gallagher, Shantu Amin, and Philip Lazarus ...............................1892 Polychlorinated Biphenyls and Risk of Testicular Germ Cell Tumors. Katherine A. McGlynn, Sabah M. Quraishi, Barry I. Graubard, Jean-Philippe Weber, Mark V. Rubertone, and Ralph L. Erickson ..........1901
Experimental Therapeutics, Molecular Targets, and Chemical Biology Novel Microtubule Polymerization Inhibitor with Potent Antiproliferative and Antitumor Activity. Sonia Arora, Xin I. Wang, Susan M. Keenan, Christina Andaya, Qiang Zhang, Youyi Peng, and William J. Welsh ....................................................................................1910 Identification of Polo-like Kinase 1 as a Potential Therapeutic Target in Anaplastic Thyroid Carcinoma. Tito Claudio Nappi, Paolo Salerno, Horst Zitzelsberger, Francesca Carlomagno, Giuliana Salvatore, and Massimo Santoro .............................................................................1916 Characterization of a Novel Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor with a Unique Mechanism of Action for Cancer Therapy. Sherif Daouti, Huisheng Wang, Wen-hui Li, Brian Higgins, Kenneth Kolinsky, Kathryn Packman, Anthony Specian, Jr., Norman Kong, Nicholas Huby, Yang Wen, Qing Xiang, Frank J. Podlaski, Yang He, Nader Fotouhi, David Heimbrook, and Huifeng Niu..............................1924
Design and Activity of a Murine and Humanized Anti-CEACAM6 Single-Chain Variable Fragment in the Treatment of Pancreatic Cancer. Christopher J. Riley, Kevin P. Engelhardt, Jose W. Saldanha, Wenqing Qi, Laurence S. Cooke, Yingting Zhu, Satya T. Narayan, Kishore Shakalya, Kimiko Della Croce, Ivan G. Georgiev, Raymond B. Nagle, Harinder Garewal, Daniel D. Von Hoff, and Daruka Mahadevan..........................................................................1933 LY303511 Enhances TRAIL Sensitivity of SHEP-1 Neuroblastoma Cells via Hydrogen Peroxide–Mediated Mitogen-Activated Protein Kinase Activation and Up-regulation of Death Receptors. Kirthan Shenoy, Yongfei Wu, and Shazib Pervaiz .............................................................1941 Chemoresistant Colorectal Cancer Cells, the Cancer Stem Cell Phenotype, and Increased Sensitivity to Insulin-like Growth Factor Receptor-I Inhibition. Nikolaos A. Dallas, Ling Xia, Fan Fan, Michael J. Gray, Puja Gaur, George van Buren II, Shaija Samuel, Michael P. Kim, Sherry J. Lim, and Lee M. Ellis......................................1951 Sustained Src Inhibition Results in Signal Transducer and Activator of Transcription 3 (STAT3) Activation and Cancer Cell Survival via Altered Janus-Activated Kinase–STAT3 Binding. Banibrata Sen, Babita Saigal, Nila Parikh, Gary Gallick, and Faye M. Johnson..............1958 Acquired Resistance to 17-Allylamino-17-Demethoxygeldanamycin (17-AAG, Tanespimycin) in Glioblastoma Cells. Nathalie Gaspar, Swee Y. Sharp, Simon Pacey, Chris Jones, Michael Walton, Gilles Vassal, Suzanne Eccles, Andrew Pearson, and Paul Workman..........................1966 Down-regulation of Vascular Endothelial Growth Factor Receptor 2 Is a Major Molecular Determinant of Proteasome Inhibitor–Mediated Antiangiogenic Action in Endothelial Cells. Markus Meissner, Gabi Reichenbach, Monika Stein, Igor Hrgovic, Roland Kaufmann, and Jens Gille.................................................................................................1976 Mitogen-Activated Protein Kinase Inhibition Induces Translocation of Bmf to Promote Apoptosis in Melanoma. Matthew W. VanBrocklin, Monique Verhaegen, Maria S. Soengas, and Sheri L. Holmen ...............1985 The Interleukin-11 Receptor ␣ as a Candidate Ligand-Directed Target in Osteosarcoma: Consistent Data from Cell Lines, Orthotopic Models, and Human Tumor Samples. Valerae O. Lewis, Michael G. Ozawa, Michael T. Deavers, Guiying Wang, Tomo Shintani, Wadih Arap, and Renata Pasqualini.......................................................1995
Immunology Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome. Michael Gobert, Isabelle Treilleux, Nathalie Bendriss-Vermare, Thomas Bachelot, Sophie Goddard-Leon, Vanessa Arfi, Cathy Biota, Anne Claire Doffin, Isabelle Durand, Daniel Olive, Solène Perez, Nicolas Pasqual, Christelle Faure, Isabelle Ray-Coquard, Alain Puisieux, Christophe Caux, Jean-Yves Blay, and Christine Ménétrier-Caux..........................................2000 IFN␥ Promotes Papilloma Development by Up-Regulating Th17-Associated Inflammation. Mingjie Xiao, Chunhui Wang, Jinhua Zhang, Zhiguang Li, Xueqiang Zhao, and Zhihai Qin................2010 Enhanced Immune Recognition of Cryptic Glycan Markers in Human Tumors. Thomas E. Newsom-Davis, Denong Wang, Lawrence Steinman, Paul F-T. Chen, Lai-Xi Wang, A. Katharina Simon, and Gavin R. Screaton.............................................................................2018 Tumor-Induced Suppression of CTL Expansion and Subjugation by gp96-Ig Vaccination. Taylor H. Schreiber, Vadim V. Deyev, Joseph D. Rosenblatt, and Eckhard R. Podack ..........................................2026
Contents (Continued) Kinetic Preservation of Dual Specificity of Coprogrammed Minor Histocompatibility Antigen-Reactive Virus-Specific T Cells. Marleen M. van Loenen, Renate S. Hagedoorn, Michel G.D. Kester, Manja Hoogeboom, Roel Willemze, J.H. Frederik Falkenburg, and Mirjam H.M. Heemskerk .................................................................2034
RGS17, an Overexpressed Gene in Human Lung and Prostate Cancer, Induces Tumor Cell Proliferation Through the Cyclic AMP-PKA-CREB Pathway. Michael A. James, Yan Lu, Yan Liu, Haris G. Vikis, and Ming You..................................................................2108
Prevention Molecular Biology, Pathobiology, and Genetics Heat-Induced Perturbations of DNA Damage Signaling Pathways are Modulated by Molecular Chaperones. Andrei Laszlo and I. Fleischer ........................................................................................2042 E-Cadherin Deficiency Initiates Gastric Signet-Ring Cell Carcinoma in Mice and Man. Bostjan Humar, Vanessa Blair, Amanda Charlton, Helen More, Iain Martin, and Parry Guilford.........................................2050 Activation of Ribosomal RNA Transcription by Hepatitis C Virus Involves Upstream Binding Factor Phosphorylation via Induction of Cyclin D1. Santanu Raychaudhuri, Vanessa Fontanes, Bhaswati Barat, and Asim Dasgupta.................................................................................2057 Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy. Johannes H. Schulte, Soyoung Lim, Alexander Schramm, Nicolaus Friedrichs, Jan Koster, Rogier Versteeg, Ingrid Ora, Kristian Pajtler, Ludger Klein-Hitpass, Steffi Kuhfittig-Kulle, Eric Metzger, Roland Schüle, Angelika Eggert, Reinhard Buettner, and Jutta Kirfel........................................................................................2065 EphA2 (Re)-Expression Prompts Invasion of Melanoma Cells Shifting from Mesenchymal to Amoeboid-like Motility Style. Matteo Parri, Maria Letizia Taddei, Francesca Bianchini, Lido Calorini, and Paola Chiarugi..................................................................................2072 Alternative Splicing of Cyr61 Is Regulated by Hypoxia and Significantly Changed in Breast Cancer. Marc Hirschfeld, Axel zur Hausen, Herta Bettendorf, Markus Jäger, and Elmar Stickeler.................................................................................2082 Unsupervised Analysis of Transcriptomic Profiles Reveals Six Glioma Subtypes. Aiguo Li, Jennifer Walling, Susie Ahn, Yuri Kotliarov, Qin Su, Martha Quezado, J. Carl Oberholtzer, John Park, Jean C. Zenklusen, and Howard A. Fine ................................................................................2091 Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence. Eli S. Williams, Rebekah Klingler, Brian Ponnaiya, Tanja Hardt, Evelin Schrock, Susan P. Lees-Miller, Katheryn Meek, Robert L. Ullrich, and Susan M. Bailey...................................................2100
Sulforaphane Inhibits Prostate Carcinogenesis and Pulmonary Metastasis in TRAMP Mice in Association with Increased Cytotoxicity of Natural Killer Cells. Shivendra V. Singh, Renaud Warin, Dong Xiao, Anna A. Powolny, Silvia D. Stan, Julie A. Arlotti, Yan Zeng, Eun-Ryeong Hahm, Stanley W. Marynowski, Ajay Bommareddy, Dhimant Desai, Shantu Amin, Robert A. Parise, Jan H. Beumer, and William H. Chambers ......................................................................2117
Systems Biology and Emerging Technologies L-Amino
Acid Transporter-1 and Boronophenylalanine-Based Boron Neutron Capture Therapy of Human Brain Tumors. Allah Detta and Garth S. Cruickshank.......................................................................2126 Granulocyte Macrophage Colony-Stimulating Factor Inhibits Breast Cancer Growth and Metastasis by Invoking an Anti-Angiogenic Program in Tumor-Educated Macrophages. Tim D. Eubank, Ryan D. Roberts, Mahmood Khan, Jennifer M. Curry, Gerard J. Nuovo, Periannan Kuppusamy, and Clay B. Marsh ............................................2133
Tumor Microenvironment Dysfunctional Microvasculature as a Consequence of Shb Gene Inactivation Causes Impaired Tumor Growth. Nina S. Funa, Vitezslav Kriz, Guangxiang Zang, Gabriela Calounova, Björn Åkerblom, Jaroslav Mares, Erik Larsson, Ying Sun, Christer Betsholtz, and Michael Welsh..................................................................................2141
Corrections Correction: Article on Combination Therapy Using PD 0332991 and Bortezomib ....................................................................................2149 Correction: Article on Differential Sensitivity to IGF-IR Inhibitor ....................................................................................2149
