Eur Radiol (2003) 13:1849–1858 DOI 10.1007/s00330-002-1785-4
Catherina S. P. van Rijswijk Maartje J. A. Geirnaerdt Pancras C. W. Hogendoorn Johannes L. Peterse Frits van Coevorden Antonie H. M. Taminiau Rob A. E. M. Tollenaar Bin B. R. Kroon Johan L. Bloem
Received: 12 June 2002 Revised: 10 October 2002 Accepted: 25 November 2002 Published online: 8 January 2003 © Springer-Verlag 2003
C.S.P. van Rijswijk (✉) · J.L. Bloem Department of Radiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands e-mail:
[email protected] Tel.: +31-71-5263377 Fax: +31-71-5248256 M.J.A. Geirnaerdt Department of Radiology, Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands P.C.W. Hogendoorn Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands J.L. Peterse Department of Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands F. van Coevorden · B.B.R. Kroon Department of Surgery, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands A.H.M. Taminiau Department of Orthopedic Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands R.A.E.M. Tollenaar Department of Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
M U S C U L O S K E L E TA L
Dynamic contrast-enhanced MR imaging in monitoring response to isolated limb perfusion in high-grade soft tissue sarcoma: initial results
Abstract The objective of this study was to evaluate whether dynamic contrast-enhanced MR imaging can determine tumor response and localize residual viable tumor after isolated limb perfusion (ILP) chemotherapy in soft tissue tumors. Twelve consecutive patients, with histologically proven high-grade soft tissue sarcoma, prospectively underwent nonenhanced MR and dynamic contrastenhanced MR imaging before and after ILP. Tumor volume was measured on non-enhanced MR images. The temporal change of signal intensity in a region of interest on dynamic contrast-enhanced MR images was plotted against time. Start, pattern, and progression of enhancement were recorded. Histopathologic response was defined as complete response if no residual viable tumor was present, partial remission if
