e2 e1 fgg' himakjbcdln

Figure S1. Phylogenetic tree of selected cytochromes b. Bootstrap support was obtained from 100 replications. Clades from A to J are marked according to the previously published tree (Dibrova et al., 2013). New clades K, L, M, N and G’ are colored red. The tree leaves are colored according to the taxonomy of the organism (see color codes in Figure 2 of the main text). The color legend for the gene neighborhoods is below the figure. Additional heme binding site 47 36 57 86 44

58

35 29 17

A

16 40

95 99 57 30 74 100 42 50 15

46 77

100

K

75

58 30 83 32 45 95 51 32 43

77 67

J B C

100 96 54 82 95 67 72 100 71 48 53 19 49 53

43

16 61

46

93 92

D

49 98 99 36 27 30

100 39

95 100 53

85 96 44 100 100 20

M

70 88

32

100 99

97

40

95 100

84

59

100 97 100

95

35 15

20 24 42

65

I

32 36 78 29

100

80 79 62 44 36

19

87 73

19 25 46

44

44 59 44 66

L

45 95 38

52 100

H

99 98

93 91 100 100

64 100

38

G'

100 31

100 54 62 100

19

100

64 47 100 66 33

61 90 86

38

G

39 48

28

99 89

66

31

41

93 41 80 63 86 99

69

100

25 59 50 100 99 73 53 68 42 72

N

44 83 84

100

73 44 65 100

18 86

F

48

98 94

53 97 97 80 86 40 16 27 100

76

51

99 96 100 100 63 72 99

E1

100 57 50 82 83

55

20 99

85 55

6671 49 36 56

39 39

59 100 100 38 22 20

75 100 75 100 100

E2

90 99 53 98

37

100 57 34

65 100

39 82

41

100 69 82

Cal7507 3601-Cal7507 3600|Calothrix sp. PCC 7507 Npun F0310-Npun F0311|Nostoc punctiforme PCC 73102 Anacy 0705-Anacy 0704|Anabaena cylindrica PCC 7122 alr3421-alr3422|Nostoc sp. PCC 7120 Cylst 0825-Cylst 0824|Cylindrospermum stagnale PCC 7417 Chro 4126-Chro 4125|Chroococcidiopsis thermalis PCC 7203 Riv7116 2421-Riv7116 2420|Rivularia sp. PCC 7116 Glo7428 2540-Glo7428 2541|Gloeocapsa sp. PCC 7428 Mic7113 6032-Mic7113 6033|Microcoleus sp. PCC 7113 Cha6605 5227-Cha6605 5226|Chamaesiphon minutus PCC 6605 Osc7112 0899-Osc7112 0898|Oscillatoria nigro-viridis PCC 7112 GEI7407 3542-GEI7407 3543|Geitlerinema sp. PCC 7407 Tery 1137-Tery 1136|Trichodesmium erythraeum IMS101 PCC7418 3067-PCC7418 3066|Halothece sp. PCC 7418 Dacsa 2331-Dacsa 2330|Dactylococcopsis salina PCC 8305 AM1 4666-AM1 4665|Acaryochloris marina MBIC11017 Cri9333 0821-Cri9333 0820|Crinalium epipsammum PCC 9333 slr0342-slr0343|Synechocystis sp. PCC 6803 MAE 33570-MAE 33560|Microcystis aeruginosa NIES-843 NIES39 M02420-NIES39 M02410|Arthrospira platensis NIES-39 Pse7367 2580-Pse7367 2581|Pseudanabaena sp. PCC 7367 Syn6312 3601-Syn6312 3600|Synechococcus sp. PCC 6312 tlr0796-tlr0797|Thermosynechococcus elongatus BP-1 Cyagr 1601-Cyagr 1600|Cyanobium gracile PCC 6307 P9303 21851-P9303 21841|Prochlorococcus marinus str. MIT 9303 Ple7327 1434-Ple7327 1433|Pleurocapsa sp. PCC 7327 Sta7437 2708-Sta7437 2709|Stanieria cyanosphaera PCC 7437 Cyan7822 5195-Cyan7822 5196|Cyanothece sp. PCC 7822 Cyan10605 3018-Cyan10605 3019|Cyanobacterium aponinum PCC 10605 Lepto7376 3192-Lepto7376 3193|Leptolyngbya sp. PCC 7376 gvip265-gvip264|Gloeobacter violaceus PCC 7421 gvip258-gvip257|Gloeobacter violaceus PCC 7421 Cha6605 5913-Cha6605 5912|Chamaesiphon minutus PCC 6605 AM1 6000|Acaryochloris marina MBIC11017 Chro 3047|Chroococcidiopsis thermalis PCC 7203 Glo7428 3997|Gloeocapsa sp. PCC 7428 Chro 4114|Chroococcidiopsis thermalis PCC 7203 Mic7113 2526|Microcoleus sp. PCC 7113 Pse7367 0446|Pseudanabaena sp. PCC 7367 Riv7116 6402|Rivularia sp. PCC 7116 Anacy 1866|Anabaena cylindrica PCC 7122 Cal7507 4358|Calothrix sp. PCC 7507 Cylst 2931|Cylindrospermum stagnale PCC 7417 all0253|Nostoc sp. PCC 7120 Npun R2785|Nostoc punctiforme PCC 73102 DAMO 0821|Candidatus Methylomirabilis oxyfera Cabther A0913|Candidatus Chloracidobacterium thermophilum B Ctha 0473|Chloroherpeton thalassium ATCC 35110 Paes 1779|Prosthecochloris aestuarii DSM 271 Ppha 0467|Pelodictyon phaeoclathratiforme BU-1 CT0303|Chlorobium tepidum TLS Cpar 1734|Chlorobaculum parvum NCIB 8327 AEG59790.1-AEG59791.1|Desulfotomaculum ruminis DSM 2154 ACL18274.1-ACL18275.1|Desulfitobacterium hafniense DCB-2 ABZ83854.1-ABZ83855.1|Heliobacterium modesticaldum Ice1 BSU22550-BSU22540|Bacillus subtilis subsp. subtilis str. 168 BAC13731.1-BAC13730.1|Oceanobacillus iheyensis HTE831 BAH43467.1-BAH43468.1|Brevibacillus brevis NBRC 100599 Psta 3849|Pirellula staleyi DSM 6068 EAQ81031.1|Blastopirellula marina DSM 3645 AMV19716.1|Planctomyces sp. SH-PL14 GAU 0696|Gemmatimonas aurantiaca T-27 ADG66274.1|Planctopirus limnophila DSM 3776 Sinac 6679|Singulisphaera acidiphila DSM 18658 AMV36736.1|Planctomyces sp. SH-PL62 Isop 1950|Isosphaera pallida ATCC 43644 SCE1572 02805|Sorangium cellulosum So0157-2 EDL57571.1|Gimesia maris DSM 8797 KHE92659.1-suIV|Candidatus Scalindua brodae CAJ73854.1|Candidatus Kuenenia stuttgartiensis GAB64150.1|Candidatus Jettenia caeni KKO18694.1|Candidatus Brocadia fulgida GAN33511.1|Candidatus Brocadia sinica JPN1 KXK25515.1|Candidatus Brocadia sinica LFML04 1074|Leptospirillum ferriphilum ML-04 NIDE0899|Candidatus Nitrospira defluvii NIDE3889|Candidatus Nitrospira defluvii Acid 6208|Candidatus Solibacter usitatus Ellin6076 Rxyl 2711-Rxyl 2956|Rubrobacter xylanophilus DSM 9941 Rxyl 2957-Rxyl 2710|Rubrobacter xylanophilus DSM 9941 Cabther A0771|Candidatus Chloracidobacterium thermophilum B OAI47698.1|Planctomycetaceae bacterium SCGC AG-212-F19 Cwoe 5927-Cwoe 5926|Conexibacter woesei DSM 14684 AciX8 2892|Granulicella mallensis MP5ACTX8 AciX9 2158|Granulicella tundricola MP5ACTX9 Acid 7586|Candidatus Solibacter usitatus Ellin6076 EAQ77017.1|Blastopirellula marina DSM 3645 ZPR 1407|Zunongwangia profunda SM-A87 Oter 3544|Opitutus terrae PB90-1 ABX10598.1|uncultured planctomycete 6N14 EDL59929.1|Gimesia maris DSM 8797 GAN31713.1|Candidatus Brocadia sinica JPN1 KXK28356.1|Candidatus Brocadia sinica KKO20068.1-suIV|Candidatus Brocadia fulgida GAB63685.1-suIV|Candidatus Jettenia caeni CAJ70967.1|Candidatus Kuenenia stuttgartiensis KKO20514.1-suIV|Candidatus Brocadia fulgida KXK25346.1-suIV|Candidatus Brocadia sinica KHE93570.1|Candidatus Scalindua brodae Gmet 1923|Geobacter metallireducens GS-15 Thal 0369|Thermocrinis albus DSM 14484 HTH 1333|Hydrogenobacter thermophilus TK-6 aq 044|Aquifex aeolicus VF5 HY04AAS1 1534|Hydrogenobaculum sp. Y04AAS1 SUN 0209|Sulfurovum sp. NBC37-1 NIS 1584|Nitratiruptor sp. SB155-2 C694 07975|Helicobacter pylori 26695 SULAZ 0289|Sulfurihydrogenibium azorense Az-Fu1 PERMA 0587|Persephonella marina EX-H1 SAR116 2188|Candidatus Puniceispirillum marinum IMCC1322 MICA 1674|Micavibrio aeruginosavorus ARL-13 amb4089|Magnetospirillum magneticum AMB-1 RSKD131 2793|Rhodobacter sphaeroides KD131 BJ6T 73410|Bradyrhizobium japonicum USDA 6 Astex 1142|Asticcacaulis excentricus CB 48 PB2503 10629|Parvularcula bermudensis HTCC2503 SL003B 1173|Polymorphum gilvum SL003B-26A1 RC0359|Rickettsia conorii str. Malish 7 Mmc1 0357|Magnetococcus marinus MC-1 SAR11G3 00715|Candidatus Pelagibacter sp. IMCC9063 Za10 0344|Zymomonas mobilis subsp. mobilis NCIMB 11163 AFE 3110|Acidithiobacillus ferrooxidans ATCC 23270 AFE 2730|Acidithiobacillus ferrooxidans ATCC 23270 Nmul A1004|Nitrosospira multiformis ATCC 25196 TVNIR 2621|Thioalkalivibrio nitratireducens DSM 14787 LPE509 00320|Legionella pneumophila subsp. pneumophila LPE509 MCA1961|Methylococcus capsulatus str. Bath Bxe A0415|Burkholderia xenovorans LB400 Tbd 1832|Thiobacillus denitrificans ATCC 25259 CV 4007|Chromobacterium violaceum ATCC 12472 Tmz1t 1403|Thauera sp. MZ1T CAP2UW1 0315|Candidatus Accumulibacter phosphatis clade IIA str. UW-1 Rmag 0010|Candidatus Ruthia magnifica str. Cm (Calyptogena magnifica) M5M 17645|Simiduia agarivorans SA1 DSM 21679 PXO 00440|Xanthomonas oryzae pv. oryzae PXO99A Avin 13070|Azotobacter vinelandii DJ Patl 3700|Pseudoalteromonas atlantica T6c VC0574|Vibrio cholerae O1 biovar El Tor str. N16961 ASA 0336|Aeromonas salmonicida subsp. salmonicida A449 Gmet 0539-Gmet 3585|Geobacter metallireducens GS-15 Selin 2603-Selin 2604|Desulfurispirillum indicum S5 Dacet 1797|Denitrovibrio acetiphilus DSM 12809 DEFDS 0675-DEFDS 0676|Deferribacter desulfuricans SSM1 THEYE A1159-THEYE A1160|Thermodesulfovibrio yellowstonii DSM 11347 CAP2UW1 1327|Candidatus Accumulibacter phosphatis clade IIA str. UW-1 CAP2UW1 1324|Candidatus Accumulibacter phosphatis clade IIA str. UW-1 amb2225|Magnetospirillum magneticum AMB-1 HTH 0156|Hydrogenobacter thermophilus TK-6 Turpa 2107|Turneriella parva DSM 21527 Deba 1754|Desulfarculus baarsii DSM 2075 CUS89966.1|2|Candidatus Kryptonium thompsoni CUS85844.1|2|Candidatus Kryptonium thompsoni CUS78125.1|2|Candidatus Kryptonium thompsoni CUT03256.1|2|Candidatus Chrysopegis kryptomonas CUU09713.1|2|Candidatus Kryptobacter tengchongensis CUU07947.1|2|Candidatus Kryptobacter tengchongensis KXK07380.1|2|Acidobacteria bacterium OLB17 KPK10738.1|2|Anaerolineae bacterium SG8 19 KPL21884.1|2|Anaerolineae bacterium SM23 84 KKU19708.1|1|Candidatus Saccharibacteria bacterium GW2011 GWA2 46 10 KPK86900.1|1|Bacteroides sp. SM23 62 1 KPL16532.1|1|Bacteroides sp. SM23 62 KWT86068.1|1|Nitrospirae bacterium HCH-1 KJU86151.1|1|Candidatus Magnetobacterium bavaricum Haur 4252|Herpetosiphon aurantiacus DSM 785 CLDAP 20090|Caldilinea aerophila DSM 14535 NBRC 104270 KHE90388.1-suIV|Candidatus Scalindua brodae PUV 26680|Parachlamydia acanthamoebae UV-7 CRX37522.1|1|Estrella lausannensis wcw 1967|Waddlia chondrophila WSU 86-1044 CDZ79846.1|1|Candidatus Rubidus massiliensis Gmet 2119-Gmet 2120|Geobacter metallireducens GS-15 Acid 3505|Candidatus Solibacter usitatus Ellin6076 DAMO 0768|Candidatus Methylomirabilis oxyfera YM304 04010-YM304 04020|Ilumatobacter coccineus YM16-304 EFH85446.1-EFH85445.1|Ktedonobacter racemifer DSM 44963 LFML04 1933-LFML04 1932|Leptospirillum ferriphilum ML-04 Dole 0198-Dole 0199|Desulfococcus oleovorans Hxd3 Sinac 1830-Sinac 1831|Singulisphaera acidiphila DSM 18658 AMV37279.1-suIV|Planctomyces sp. SH-PL62 Psta 2936-Psta 2935|Pirellula staleyi DSM 6068 AMV21965.1-suIV|Planctomyces sp. SH-PL14 EAQ80215.1-suIV|Blastopirellula marina DSM 3645 BMS 0208-BMS 0209|Bacteriovorax marinus SJ DAMO 1671-DAMO 1670|Candidatus Methylomirabilis oxyfera KKR31821.1|2|Candidatus Gottesmanbacteria bacterium GW2011 GWC2 39 8 KMP12479.1-KMP12478.1|Nitrospina sp. SCGC AAA799 A02 Acid 4387-Acid 4386|Candidatus Solibacter usitatus Ellin6076 KKO21048.1|Candidatus Brocadia fulgida KXK29968.1-suIV|Candidatus Brocadia sinica GAB61554.1-suIV|Candidatus Jettenia caeni CAJ72226.1-suIV|Candidatus Kuenenia stuttgartiensis KHE91632.1-suIV|Candidatus Scalindua brodae KHE90665.1-suIV|Candidatus Scalindua brodae CAJ75333.1-suIV|Candidatus Kuenenia stuttgartiensis KXK30656.1-suIV|Candidatus Brocadia sinica GAB63915.1-suIV|Candidatus Jettenia caeni KKO18437.1-suIV|Candidatus Brocadia fulgida HVO 0842-HVO 0841|Haloferax volcanii DS2 Hbor 23760-Hbor 23770|Halogeometricum borinquense DSM 11551 Hqrw 1651-Hqrw 1652|Haloquadratum walsbyi C23 HTIA 2619-HTIA 2620|Halorhabdus tiamatea SARL4B VNG0583G-VNG0582C|Halobacterium sp. NRC-1 rrnAC0732-rrnAC0731|Haloarcula marismortui ATCC 43049 Hmuk 3097-Hmuk 3096|Halomicrobium mukohataei DSM 12286 HacjB3 11110-HacjB3 11105|Halalkalicoccus jeotgali B3 L593 03290-L593 03285|Salinarchaeum sp. Harcht-Bsk1 Hlac 0647-Hlac 0648|Halorubrum lacusprofundi ATCC 49239 TTHA1930|Thermus thermophilus HB8 Marky 2180|Marinithermus hydrothermalis DSM 14884 Mesil 0470|Meiothermus silvanus DSM 9946 Ocepr 0104|Oceanithermus profundus DSM 14977 DR 0436|Deinococcus radiodurans R1 Acel 0961|Acidothermus cellulolyticus 11B HVO 2654|Haloferax volcanii DS2 Hlac 1333|Halorubrum lacusprofundi ATCC 49239 Hmuk 2472|Halomicrobium mukohataei DSM 12286 rrnAC1196|Haloarcula marismortui ATCC 43049 Hbor 35020|Halogeometricum borinquense DSM 11551 HVO B0162|Haloferax volcanii DS2 Kcr 1166|Candidatus Korarchaeum cryptofilum OPF8 UP 000031661.1|Thaumarchaeota archaeon JGI OTU-1 UP 000030978.1|Thaumarchaeota archaeon JGI OTU-1 UP 000025351.1|Aigarchaeota archaeon SCGC AAA471-F17 UP 000020786.1|Aigarchaeota archaeon SCGC AAA471-E16 UP 000019706.1|Aigarchaeota archaeon SCGC AAA471-A16 UP 000030341.1|Thaumarchaeota archaeon JGI OTU-4 CSUB C0065|Candidatus Caldiarchaeum subterraneum NTE 01577|Candidatus Nitrososphaera evergladensis SR1 NVIE 002610|Nitrososphaera viennensis EN76 Ngar c14510|Candidatus Nitrososphaera gargensis Ga9.2 NMY3 03555|Thaumarchaeota archaeon MY3 UP 000026821.1|Thaumarchaeota archaeon SCGC AAA287-E17 UP 000018799.1|Thaumarchaeota archaeon SCGC AAA007-O23 UP 000016803.1|Marine Group I thaumarchaeote SCGC AB-629-I23 AAA799D07 00307|Marine Group I thaumarchaeote SCGC AAA799-D07 UP 000033967.1|Thaumarchaeota archaeon MY2 NITUZ 40469|Thaumarchaeota archaeon N4 SU86 004530|Thaumarchaeota archaeon SAT1 CENSYa 0002|Cenarchaeum symbiosum A BG20 I1164|Candidatus Nitrosoarchaeum limnia BG20 Nlim 1947|Candidatus Nitrosoarchaeum limnia SFB1 MY1 1661|Candidatus Nitrosoarchaeum koreensis MY1 T478 1266|Candidatus Nitrosopelagicus brevis ABR53 03105|Nitrosopumilus sp. BACL13 MAG-121220-bin23 ABR52 02470|Nitrosopumilus sp. BACL13 MAG-120910-bin56 Nmar 1543|Nitrosopumilus maritimus SCM1 UP 000013671.1|Nitrosopumilus sp. AR NSED 08480|Candidatus Nitrosopumilus sp. AR2 BD31 I0641|Candidatus Nitrosopumilus salaria BD31 NADRNF5 0348|Candidatus Nitrosopumilus sp. NF5 UP 000015751.1|Nitrosopumilus sp. SJ UP 000010678.1|Nitrosopumilus sp. AR NKOR 08390|Candidatus Nitrosopumilus koreensis AR1 NPIRD3C 0016|Candidatus Nitrosopumilus sp. D3C AAA799D11 01469|Marine Group I thaumarchaeote SCGC AAA799-D11 SCCGRSA3 02360|Marine Group I thaumarchaeote SCGC RSA3 UP 000023471.1|Aigarchaeota archaeon JGI 0000106-J15 Calag 1350|Caldisphaera lagunensis DSM 15908 MROS 1772|Melioribacter roseus P3M-2 IALB 1666|Ignavibacterium album JCM 16511 Thein 0667|Thermodesulfatator indicus DSM 15286 PAE1350|Pyrobaculum aerophilum str. IM2 Acel 1781|Acidothermus cellulolyticus 11B ASAC 1488|Acidilobus saccharovorans 345-15 Msed 0321|Metallosphaera sedula DSM 5348 SSO2970|Sulfolobus solfataricus P2 Saci 2260|Sulfolobus acidocaldarius DSM 639 APE 1725|Aeropyrum pernix K1 Ta1222|Thermoplasma acidophilum DSM 1728 TVN0373|Thermoplasma volcanium GSS1 PTO1134|Picrophilus torridus DSM 9790 FACI IFERC00001G1373|Ferroplasma acidarmanus fer1 Cmaq 1912|Caldivirga maquilingensis IC-167 TTX 0318|Thermoproteus tenax Kra 1 Vdis 1232|Vulcanisaeta distributa DSM 14429 Ta1228|Thermoplasma acidophilum DSM 1728 TVN0367|Thermoplasma volcanium GSS1 Cmaq 1939|Caldivirga maquilingensis IC-167 SSO2805|Sulfolobus solfataricus P2 Saci 1861|Sulfolobus acidocaldarius DSM 639 Msed 0500|Metallosphaera sedula DSM 5348 Ahos 1653|Acidianus hospitalis W1 Ahos 0314|Acidianus hospitalis W1 Msed 0291|Metallosphaera sedula DSM 5348 SSO2656|Sulfolobus solfataricus P2 Saci 2087|Sulfolobus acidocaldarius DSM 639

0.2

Core components:

Quinone binding site

Helix 4 Helix 2

CLGG CLGG CLGG CLGG CLGG CLGG CLGG CFGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG CLGG YLSS IIAV LLAV ILSV ILSV VLAV ILAI LLAV ILSV ILSV ILSV ILSV ILSV ILSV YFGG YWGG YFGG YFGG YFGG YFGG YFGG CFGG CFGG CLGG CFGG CFGG CFGG ITGS VWGS VWGS VWGS AWGS VFGS VCGS VFGS VWGG IWGG ---VFGS VFGS VFGS VFGS VFGS VFGS VFGS VFGS VFGS TLGS TLGS AFGS AFGS TLGS VFGS VFGS VFGS VFGS VWGS VFGS VFGS IFGS CMGG CMGG CMGG CMGG CMGG CMGG CMGG CMGG SLGS AFGV AFGV VFGI AFGV AMGM AMGV AMGV SFGV SFGV NFGS NFGA NFGS IWGV TFGA TFGG TFGG TFGG NLGS NFGS SFGG NFGV YAGS YAGS YFGS YFGS FFGS FFGS FFGS FFGS FFGS FFGS FFGS FFGS FFGV YFGS FFGS VFGF LFGS FFGS CLGG CLGG YAGA CLGG CFGG HLGA HLGT CLGA HLGA YLGA CLGG WLGT WLGT WLGT WLGT WLGT WLGT WLGT GLGG GLGG GLGI GLGV GLGL GMGL GLGL GLGW RLGL CLGG GLGV GLGA GLGT GLGS GLGL GLGL ALGM CLGG CMGG CLGG CLGG CMGG CMGG CMGG CMGG CMGG CMGG CMGG GMGG CMGG GMGG CMGG CMGG CMGG CMGG CMGG CLGG CMGG CMGG CMGG CMGG TLGL TLGL TLGF ALGS SLGF ALGS ALGS SLGA SLGS SLGS FLGE FLGE FLGE FLGE FLGE MLGE LLGE LLGE LLGE LLGE LLGE LLGE SLGG YLGT ---YLGT YLGT YLGT YLGT YLGT FLGM FLGM FLGM FLGM FLGM FLGM FLGM FLGM FLGM FLGM FLGM ---M FLGM FLGM FLGM FLGM FLGM FLGM FLGM FLGM FLGM FLGM FLGM FLGM FLGM FLGM FLGM FLGM FLGM WLGA WLGA TFGQ PFGN ---WFGD VFGV QIGF WLGS WLGG WLGG WLGA WTGS WTGS WTGA ---WLGA WLGA WLGG WTGA WTGA WTGG WLGA WLGS WLGA WLGA ---WLGA WLGA WLGA

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H F Q Q Q Q E E Q Q N Q D Q Q H H H H H H H H H H H H H H H H H Q H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H Q H H H S H S H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H K K H H H K H H H H H H H H H H H H H H H H H H H H H H H H

PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY ------------------------------------PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PDWY PEWY PDWY PDWY PDWY PEWY PEWY PEWY PEWY PEWY PEWY PEWF PEWY PAWY PEWF PEWY PEWY PEWY PEWY PEWY PEWY PAWY PEWY PEWY PEWY PEWF PEWF PEWY PEWY PEWY PDFA PDFA PDFF PDWY PDWY PDWY PDWY PDWY ------P-WF P-WF ---P-WF P-WF ---PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PPWY PPWY PVWY PVWY PVWY PVWY PVWY PLWY PVWY PVWY PVWY PLWY PVWY PVWY PVWY PVWY PVWY PVWY SAWF SGWF SAWF SAWF PEWY ------------------P-WY P-WY P-WY P-WY P-WY P-WY P-WY A-WY A-WY P-WY S-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY ---P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY P-WY PDWY PDWY PDWY PDWY PDWY PDWY PDWY PDWY PDWY PDWY PDWY PDWY PDWY PDWY PDWY PDFY PDWF PDWF PDWF PDWF PDWF PDWF PEWY ---PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PEWY PDWY ------GPWF PPWP ---PDLF PDWY PDWY PDWY PPWF PDWY PDWY PDWY PDWY PPWF PPWF PPWF PPWF PPWF PLWF PPWF PPWF PPWF PPWF PPWI PPWF PPWF PPWF

Other redox domains:

#295

PF13631

Cytochrome b(N-terminal)/b6/petB

#5

PF00033

Cytochrome b(N-terminal)/b6/petB

#224

PF00355

Rieske [2Fe-2S] domain

#31

PF10399

Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal

#171

PF00032

Cytochrome b(C-terminal)/b6/petD

#81

PF00034

Cytochrome c

#31

PF02167

Cytochrome C1 family

FeS cluster domains:

#26

PF07992

Pyridine nucleotide-disulphide oxidoreductase

#20

PF03572

Peptidase family S41

#14

PF00595

PDZ domain (Also known as DHR or GLGF)

#14

PF09459

Ethylbenzene dehydrogenase

#12

PF02613

Nitrate reductase delta subunit

#8

PF00384

Molybdopterin oxidoreductase

#8

PF00999

Sodium/hydrogen exchanger family

#8

PF02254

TrkA-N domain

#7

PF13180

PDZ domain

#6

PF01568

Molydopterin dinucleotide binding domain

#5

PF02662

Methyl-viologen-reducing hydrogenase, delta subunit

#2

PF00175

Oxidoreductase NAD-binding domain

#2

PF00970

Oxidoreductase FAD-binding domain

#42

PF12838

4Fe-4S dicluster domain

#27

PF14691

Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster

#12

PF13247


#5

PF08802

Cytochrome B6-F complex Fe-S subunit

#4

PF13187


#1

PF13450

NAD(P)-binding Rossmann-like domain

#3

PF13237


#1

PF00529

HlyD family secretion protein

#2

PF00111

2Fe-2S iron-sulfur cluster binding domain

#1

PF07223

Protein of unknown function (DUF1421)

#1

PF12797

4Fe-4S binding domain

#1

PF13183


Cytochome c oxidase domains: #63

PF13442

Cytochrome C oxidase, cbb3-type, subunit III

#30

PF00115

Cytochrome C and Quinol oxidase polypeptide I

#24

PF00116

Cytochrome C oxidase subunit II, periplasmic domain

#12

PF02433

Cytochrome C oxidase, mono-heme subunit/FixO

#7

PF09678

Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)

Other domains: #12

PF13435

Cytochrome c554 and c-prime

#7

PF07690

Major Facilitator Superfamily

#3

PF14522

Cytochrome c7

#2

PF01027

Inhibitor of apoptosis-promoting Bax1

#2

PF13166

AAA domain

#2

PF13520

Amino acid permease

#1

PF01292

Prokaryotic cytochrome b561

#1

PF03546

Treacher Collins syndrome protein Treacle

#1

PF05466

Brain acid soluble protein 1 (BASP1 protein)

#1

PF07174

Fibronectin-attachment protein (FAP)

#1

PF10101

Predicted membrane protein (DUF2339)

#1

PF12730

ABC-2 family transporter protein

#1

PF13476

AAA domain

#1

PF14358

Domain of unknown function (DUF4405)