Early changes in cardiovascular structure and function in ... - TSpace
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Early changes in cardiovascular structure and function in ... - TSpace
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Bradley et al. Cardiovasc Diabetol (2016) 15:31 DOI 10.1186/s12933-016-0351-3
Cardiovascular Diabetology Open Access
ORIGINAL INVESTIGATION
Early changes in cardiovascular structure and function in adolescents with type 1 diabetes Timothy J. Bradley1, Cameron Slorach1, Farid H. Mahmud2, David B. Dunger3, John Deanfield4,5, Livia Deda2, Yesmino Elia2, Ronnie L. H. Har2, Wei Hui1, Rahim Moineddin6, Heather N. Reich7, James W. Scholey7, Luc Mertens1, Etienne Sochett2 and David Z. I. Cherney7*
Abstract Background: Children with type 1 diabetes (T1D) are at higher risk of early adult-onset cardiovascular disease. We assessed cardiovascular structure and function in adolescents with T1D compared with healthy controls and the relationships between peripheral vascular function and myocardial parameters. Methods and results: 199 T1D [14.4 ± 1.6 years, diabetes duration 6.2 (2.0–12.8) years] and 178 controls (14.4 ± 2.1 years) completed endothelial function by flow mediated vasodilatation (FMD), arterial stiffness using pulse wave velocity (PWV) along with M-mode, pulse wave and tissue Doppler, and myocardial deformation echocardiographic imaging. Systolic (113 ± 10 vs. 110 ± 9 mmHg; p = 0.0005) and diastolic (62 ± 7 vs. 58 ± 7 mmHg; p
