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Pieter C. Limburg, Martin H. van. Ryswejk, Edwin G. Moore, Mark B. Pepys. 1284. Comparable. Detection .... Faulkner, Samuel Meites, eds. 1352. Reviewers:.
EDITORIALS

Molecular

NMR in Clinical Chemistry-Where Do We Stand? Jay L. Bock

1215

Limit of Detection and Limit of Quantitation as Applied to Drug of Abuse Testing Striving for a Consensus. George M. Lawson 1218 Defining

Assessment of a Simple Colorimetric Procedure to Determine Smoking Status in Diabetic Subjects. George

Thioudellet,

Simultaneous Measurement of Cocaine, Cocaethylene, Their Metabolites, and “Crack” Pyrolysis Products by Gas ChromatographyMass Spectrometsy. Edward J. Cone,

Gerard Siest

Enzymes

of the Clearance Concept to Hyponatremic and Hypernatremic Disorders: A Phenomenological Analysis. Ahmed Said Shoker 1220

A Simple Enzyme-Linked

Laboratory Utilization European

Management

Specifications

and

for

Imprecision and Inaccuracy Compared with Operating

Specifications That Assure the Quality Required by US CLIA Proflency-Testing Criteria. James 0. Westgard, Julie J. Seehafer, Patricia L. Barry 1228 Limit of Detection (LOD)/Limit of Quantitation (LOQ): Comparison of the Empirical and the Statistical Methods Exemplified with GC-MS Assays of Abused Drugs. David A. Armbruster, Margaret D. Tiliman, Linda M. Hubbs 1233 Automation Techniques

and Analytical

Simultaneous Separation and Quantification of Free and MetalChelated Protoporphyrins in Blood by Three-Dimensional HPLC. Haruo Sato, Ken-ichi Ido, Ken Kimura 1239 High-Resolution 1H-NMR Spectroscopy of Blood Plasma

for Metabolic Studies. Ron A. Wevers, Udo Engelke, Arend Heerschap 1245

2A

and Protein

1251

Markers

Martin Bonde, Christian Per Qvist

Phillipou, Stephen K James, Christopher J. Seaborn, Patrick J. Phillips 1296

Mary Hillsgrove, Darwin

Immunosorbent Assay of Human Osteocalcin. Christian Rosenquist,

William D. 1299

New Decision Limits

Fledelius, 1258

MB Isoforms: Markers of Ischemic Myocardial Damage. Mojgan Hossein-Nia, Panny Kallis, Patrick A. Brown, Michael R. Chester, Juan C. Kaski, Andrew J. Murday, Tom Treasure, David W. Holt 1265 Creatine Sensitive

ARTICLES

and Toxicology

Expression of Enzymatically Human Pancreatic Lipase in V79 Cells: Purification and Characterization of the Recombinant Enzyme. Francesca Canalias, Athanase Visvikis, Christine Stable Active

REVIEW Application

Drug Monitoring

Pathology

Kinase

and Quality-Control Material for Detecting Human Chorionic Gonadotropin Misuse in Sports. Paul Laidler, David A Cowan, Robert C. Hider, Andrew T. Kicman 1306 Automated

HPLC

Assay

of

Fluoxetine and Norfluoxetine in Serum. James H. Nichols, Joel R. Charison, George M. Lawson 1312 Endocrinology

Alkaline Serum

Phosphatase Isoforms in After Liver Allograft Surgery.

Julie Randoiph-Habecker, Lott, Raymond J. Tesi

John A. 1272

of Macro Creatine Kinase Type 1 and Type 2 Isoenzymes to Laboratory and Clinical Data. Kyung N. Lee, Gyorgy Csako, Patricia Bernhardt, Ronald J. Elm 1278 Relevance

Rapid Automated Enzyme Immunoassay of Serum Amyloid Julie Wilkins, J. Ruth Gallimore,

A.

Glenys A Tennent, Philip N. Hawkins, Martin H. van Ryswejk, Edwin G. Moore, Mark B. Pepys 1284 Pieter C. Limburg,

Comparable

Detection

of Acute

Myocardial Infarction by Creatine Kinase MB Isoenzyme and Cardiac Troponin I. Jesse Adams, Kenneth Schechtman, Yvonne Landt, Jack Lad enson, Allan S. Jaffe 1291

CLINICAL CHEMISTRY, VOL. 40, No. 7, 1994

Glycohemoglobin Measured by Automated Affinity HPLC Correlates with Both Short-Term and Long-Term Antecedent Glycemia. William T. Cefalu, Zhong Q. Wang, Audrey Bell-Farrow, Fran D. Kiger, Camille Izlar 1317 Enzymatic Quantification of 1,5-Anhydro-D-Glucitol: Evaluation and Clinical Application. George

Phillipou, Stephen K James, R. Gordon Frith, Robert K Farrant, 1322 Patrick J. Phillips General

Clinical

Chemistry

Stability of Plasma Lactate in Vitro in the Presence of Antiglycolytic Agents. Rex Astles, Charles P. Williams, Frank Sedor 1327 Immunology ELISA-Type Titertray Assay for 1gM Anti-GM 1 Autoantibodies. Einar Bech, Johannes Jakobsen, Torben F. Qrntoft 1331

CASE REPORTS

Platelet-Poor

for Clinical in Biliary (High-Molecular-Mass) and Liver Isoforms of Alkaline Phosphatase After Baboon-to-Human Liver Transplantation. Donald Mercer, Mary Tang, Ignazio B. Marino, Anthony Demetris, John Fung, Thomas Starzl, Vijay Warty 1335 Changes

Aspartate Aminotransferase Macroenzyme Complex in Serum Identified and Characterized. Marie-Jos#{233} Stasia, Anny Surla, Jean-Charles Renversez, Fran#{231}oise Pens, Arlette Morel -Femelez, Francoise Morel 1340

TECHNICAL BRIEF Rapid Measurement of Corticotropin (ACTH) with a Modified Immunochemiluminescent Assay. Hershel Raff, Joseph L. Shaker, Debra K Nelson, James W. Findling 1344

LETTERS of Blood Donation and Iron Supplementation on Indicators of Iron Status. Thomas B. Ledue, Wendy Y. Craig, Robert F. Ritchie, James E. Haddow 1345 Influence

Demonstrated

Plasma Not Suitable Endotoxin Testing, in Horses. Paul J.G.M.

Steverink, Augueste Har J. M. Salden

Sturk,

BOOK REVIEWS Body Fluids, 3rd ed. Carl R. Kjeldsberg, Joseph A. Knight.

1346 Reviewer:

Should

Accuracy

of Iron

Measurements Be Improved? W. Tietz, Alan D. Rinker Response: L. Witte

Norbert 1347

John H. Eckfeldt, David

A. Sasse

1352

Geriatric Clinical Chemistry: Reference Values. Willard R. Faulkner, Samuel Meites, eds. Reviewers:

1348

Edward

James A. Sadowski,

J. Sokoll

Lori 1352

Specificity

of Digoxin Immunoassays Toward Digoxin Metabolites. Pradip Datta, Fred Larsen 1349

Molecular Biology and Pathology: Guidebook for Quality Control. Daniel H. Farkas, ed.

of Inorganic Phosphorus by Hitachi 7 17/747 and Ektachem 700 Without Bilirubin Interferences. Hans Gunther WahI, Isolde Riedlinger, Hartmut M. Liebich 1349

Reviewer: Andrew

Assay

Response:

Mitchell

G. Scott

M. Hruszkewycz 1352

Neonatology and Clinical Biochemistry. Anne Green, Imogen Morgen.

1349

Reviewer: Barbara Effects of Cigarette Smoking on Plasma Lipids, Apolipoproteins, and Lipoprotein(a) in Healthy Subjects. Rudiger Siekmeier, Winfried Mdrz,

Hartmut Kronenberger, Seiffert, Werner Gm/i

A

Ulirich B. 1350

M. Goldsmith 1353

THE CLINICAL CHEMIST Compiled

by David E. Bruns

CLINICAL CHEMISTRY, Vol. 40, No. 7, 1994

1354

3A

Volume 40, No. 7(B) July1994

CLCHAU 40(7) 1359-1476 Part 2 of 2 ISSN 0009-9147

llLnfi1llS

Proceedings of the Arnold 0. Beckman/IFCC European Conference on Environmental Toxicology Biomarkers of Chemical Exposure 16-18 June, 1993. Munich,Germany Organizingand EditorialCommittee:Philippe Grandjean (Chairman), Stanley S. Brown, Phil Reavey, and Donald S. Young

Guest Editor: Robert Rej Arnold

0. Beckman

1359

OVERVIEW Biomarkers Phil Reavey,

of Chemical Exposure: Donald S. Young

State

of the Art. Philippe

Grandjean,

Stanley

S. Brown, 1360

ARTICLES Role of Biomarkers Ellen

K Silbergeld,

Critical

Evaluation McLean

Allan

in Identifying and Understanding Devra Lee Davis of Current

Concepts

in Exposure

Environmentally

Induced

Disease.

1363 Assessment.

Birger

G.J. Heinzow, 1368

Technical

and Scientific Developments in Exposure Marker Methodology. Eric J. Sampson, James L. Pirkie, W. Harry Hannon, Dayton T. Miller, Donald G. Patterson, John T. Bernert, David L. Ashley, Robert H. Hill, Elaine W. Gunter, Daniel C. Paschal, Francis W. Spierto, Michael J. Rich

1376

Reference

1385

Larry L. Need ham,

Validity

Limits

in Occupational

of Lead Exposure

Markers

Toxicology.

Antero

in Diagnosis

Aitio

and Surveillance.

Joseph

H. Graziano

Robert

B. Lauwerys,

Cadniiuzn: Exposure Markers as Predictors of Nephrotoxic Alfred M. Bernard, Harry A. Roels, Jean-Pierre Buchet

Effects.

Methylmercury: Significance Pal Weihe, Jesper Bo Nielsen

Exposures.

of Intrauterine

Blood Concentrations of Volatile Organic and in Groups with Suspected Exposure. Joan M. McCraw, Joe V. Wooten 4A

CLINICAL CHEMISTRY, VOL. 40, No. 7, 1994

and Postnatal

1387

1391 Philippe

Grandjean, 1395

Compounds David

in a Nonoccupationally L. Ashley, Michael A. Bonin,

Exposed Frederick

US Population L. Cardinali, 1401

Chlorinated

Dibenzo-p-dioxins

Exposure

to Mixtures

Svensson,

Lillemor

Quality

Mechanisms

Problems

in Analysis

and Congeners

Asplund,

Assurance,

and -furans:

Lars

Accreditation,

of Carcinogenesis

of Polychiorinated Hagmar and Certification:

and Individual

Biphenyls.

Complex

Use in Diagnosis

Adducts: Exposures:

Potentials

Needs

Risks: Experimental

Acceptable

Determining

Skerfving,

and Possibilities. to Cancer.

Susceptibility

Exposure

Schiatter

..

1405

Bengt-Goran

Ren#{233} Dybkaer

Stanley

Venitt

and Disease:

1416 1421

Legal

and Ethical 1426

Peter B. Farmer

and Risk Assessment.

for Assessing

Staffan

Christian

1409

Monitoring the Worker and the Community for Chemical Considerations in the US. Nicholas A. Ash ford Carcinogen

of Biomarkers.

Integrated

Exposures.

and Epidemiological

Masayuki Issues.

1438 Ikeda

Renate

1444

D. Kimbrough

1448

EXTENDED ABSTRACTS Molecular Stephen

Epidemiological

P. Faux,

Mm

Studies in Workers Exposed to Chromium-Containing Gao, T. Ching Aw, Robin A Braithwaite, Leonard S. Levy

Diesel Exhaust-Related Herman Autrup

DNA Adducts

in Garage

Workers.

A Battery of Biomarkers for Detecting Carcinogenic Vigagni, Francesca Maffei, Moreno Paolini, Renata

with Gastrointestinal Hans Opdam Risk from Fungicides. Mesirca, Laura Pozzeti,

Exposure

to Mixed Solvents. Anne Wright

Howard

J. Mason,

Patrizia

Hrelia, Fernanda

Giorgio

Cantelli-Forti

James

and 1462 P. Wheeler,

1,2- and 1,4-Cyclohexanediol. 1466

of Occupational and Environmental Exposures to Benzene by Measuring Acid in Urine. Dankwart Rauscher, Gerhard Lehnert, Jurgen Angerer

trans,trans-Muconic

Serum Total Radical-Trapping Antioxidant Parameter (TRAP) Thim J.J.M. Derhaag, Jan de Jong, Aalt Bast, Paul J.A. Borm Monitoring Occupational Exposure to Some Industrial Adducts. Nico J. van Sittert, Erik W.N. van Vliet

1460

1464

of Exposure to Cyclohexanone, Cyclohexane, and Cyclohexanol: Mr#{225}z, Eva Gdlovd, Hana Nohovd, Dana V(tkovd

Biomomtoring

to Solvents. 1458

in Long-Term Postexposure Investigations of Acetonitrile Exposures in Two Subjects. Dirk Kohlm#{252}ller, Walter Kochen

Hepatic Effects of Chronic Exposure Jaspal S. Purba, Michael D. Wright, Markers Jaroslav

Per Sabro Nielsen,

Air Analyzed

Trichloroethylene

1454

1456

Method to Study Metabolic Interactions in Humans Jesper Baelum, Lars M#{248}lhave,Steen Honor#{233} Hansen,

Exhalation

Compounds.

Chemicals

in Coal Workers.

1468

Roel P. F. Schins, 1470

by Determining

Hemoglobin 1472

CLINICAL CHEMISTRY, Vol. 40, No. 7, 1994

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