Pieter C. Limburg, Martin H. van. Ryswejk, Edwin G. Moore, Mark B. Pepys. 1284. Comparable. Detection .... Faulkner, Samuel Meites, eds. 1352. Reviewers:.
EDITORIALS
Molecular
NMR in Clinical Chemistry-Where Do We Stand? Jay L. Bock
1215
Limit of Detection and Limit of Quantitation as Applied to Drug of Abuse Testing Striving for a Consensus. George M. Lawson 1218 Defining
Assessment of a Simple Colorimetric Procedure to Determine Smoking Status in Diabetic Subjects. George
Thioudellet,
Simultaneous Measurement of Cocaine, Cocaethylene, Their Metabolites, and “Crack” Pyrolysis Products by Gas ChromatographyMass Spectrometsy. Edward J. Cone,
Gerard Siest
Enzymes
of the Clearance Concept to Hyponatremic and Hypernatremic Disorders: A Phenomenological Analysis. Ahmed Said Shoker 1220
A Simple Enzyme-Linked
Laboratory Utilization European
Management
Specifications
and
for
Imprecision and Inaccuracy Compared with Operating
Specifications That Assure the Quality Required by US CLIA Proflency-Testing Criteria. James 0. Westgard, Julie J. Seehafer, Patricia L. Barry 1228 Limit of Detection (LOD)/Limit of Quantitation (LOQ): Comparison of the Empirical and the Statistical Methods Exemplified with GC-MS Assays of Abused Drugs. David A. Armbruster, Margaret D. Tiliman, Linda M. Hubbs 1233 Automation Techniques
and Analytical
Simultaneous Separation and Quantification of Free and MetalChelated Protoporphyrins in Blood by Three-Dimensional HPLC. Haruo Sato, Ken-ichi Ido, Ken Kimura 1239 High-Resolution 1H-NMR Spectroscopy of Blood Plasma
for Metabolic Studies. Ron A. Wevers, Udo Engelke, Arend Heerschap 1245
2A
and Protein
1251
Markers
Martin Bonde, Christian Per Qvist
Phillipou, Stephen K James, Christopher J. Seaborn, Patrick J. Phillips 1296
Mary Hillsgrove, Darwin
Immunosorbent Assay of Human Osteocalcin. Christian Rosenquist,
William D. 1299
New Decision Limits
Fledelius, 1258
MB Isoforms: Markers of Ischemic Myocardial Damage. Mojgan Hossein-Nia, Panny Kallis, Patrick A. Brown, Michael R. Chester, Juan C. Kaski, Andrew J. Murday, Tom Treasure, David W. Holt 1265 Creatine Sensitive
ARTICLES
and Toxicology
Expression of Enzymatically Human Pancreatic Lipase in V79 Cells: Purification and Characterization of the Recombinant Enzyme. Francesca Canalias, Athanase Visvikis, Christine Stable Active
REVIEW Application
Drug Monitoring
Pathology
Kinase
and Quality-Control Material for Detecting Human Chorionic Gonadotropin Misuse in Sports. Paul Laidler, David A Cowan, Robert C. Hider, Andrew T. Kicman 1306 Automated
HPLC
Assay
of
Fluoxetine and Norfluoxetine in Serum. James H. Nichols, Joel R. Charison, George M. Lawson 1312 Endocrinology
Alkaline Serum
Phosphatase Isoforms in After Liver Allograft Surgery.
Julie Randoiph-Habecker, Lott, Raymond J. Tesi
John A. 1272
of Macro Creatine Kinase Type 1 and Type 2 Isoenzymes to Laboratory and Clinical Data. Kyung N. Lee, Gyorgy Csako, Patricia Bernhardt, Ronald J. Elm 1278 Relevance
Rapid Automated Enzyme Immunoassay of Serum Amyloid Julie Wilkins, J. Ruth Gallimore,
A.
Glenys A Tennent, Philip N. Hawkins, Martin H. van Ryswejk, Edwin G. Moore, Mark B. Pepys 1284 Pieter C. Limburg,
Comparable
Detection
of Acute
Myocardial Infarction by Creatine Kinase MB Isoenzyme and Cardiac Troponin I. Jesse Adams, Kenneth Schechtman, Yvonne Landt, Jack Lad enson, Allan S. Jaffe 1291
CLINICAL CHEMISTRY, VOL. 40, No. 7, 1994
Glycohemoglobin Measured by Automated Affinity HPLC Correlates with Both Short-Term and Long-Term Antecedent Glycemia. William T. Cefalu, Zhong Q. Wang, Audrey Bell-Farrow, Fran D. Kiger, Camille Izlar 1317 Enzymatic Quantification of 1,5-Anhydro-D-Glucitol: Evaluation and Clinical Application. George
Phillipou, Stephen K James, R. Gordon Frith, Robert K Farrant, 1322 Patrick J. Phillips General
Clinical
Chemistry
Stability of Plasma Lactate in Vitro in the Presence of Antiglycolytic Agents. Rex Astles, Charles P. Williams, Frank Sedor 1327 Immunology ELISA-Type Titertray Assay for 1gM Anti-GM 1 Autoantibodies. Einar Bech, Johannes Jakobsen, Torben F. Qrntoft 1331
CASE REPORTS
Platelet-Poor
for Clinical in Biliary (High-Molecular-Mass) and Liver Isoforms of Alkaline Phosphatase After Baboon-to-Human Liver Transplantation. Donald Mercer, Mary Tang, Ignazio B. Marino, Anthony Demetris, John Fung, Thomas Starzl, Vijay Warty 1335 Changes
Aspartate Aminotransferase Macroenzyme Complex in Serum Identified and Characterized. Marie-Jos#{233} Stasia, Anny Surla, Jean-Charles Renversez, Fran#{231}oise Pens, Arlette Morel -Femelez, Francoise Morel 1340
TECHNICAL BRIEF Rapid Measurement of Corticotropin (ACTH) with a Modified Immunochemiluminescent Assay. Hershel Raff, Joseph L. Shaker, Debra K Nelson, James W. Findling 1344
LETTERS of Blood Donation and Iron Supplementation on Indicators of Iron Status. Thomas B. Ledue, Wendy Y. Craig, Robert F. Ritchie, James E. Haddow 1345 Influence
Demonstrated
Plasma Not Suitable Endotoxin Testing, in Horses. Paul J.G.M.
Steverink, Augueste Har J. M. Salden
Sturk,
BOOK REVIEWS Body Fluids, 3rd ed. Carl R. Kjeldsberg, Joseph A. Knight.
1346 Reviewer:
Should
Accuracy
of Iron
Measurements Be Improved? W. Tietz, Alan D. Rinker Response: L. Witte
Norbert 1347
John H. Eckfeldt, David
A. Sasse
1352
Geriatric Clinical Chemistry: Reference Values. Willard R. Faulkner, Samuel Meites, eds. Reviewers:
1348
Edward
James A. Sadowski,
J. Sokoll
Lori 1352
Specificity
of Digoxin Immunoassays Toward Digoxin Metabolites. Pradip Datta, Fred Larsen 1349
Molecular Biology and Pathology: Guidebook for Quality Control. Daniel H. Farkas, ed.
of Inorganic Phosphorus by Hitachi 7 17/747 and Ektachem 700 Without Bilirubin Interferences. Hans Gunther WahI, Isolde Riedlinger, Hartmut M. Liebich 1349
Reviewer: Andrew
Assay
Response:
Mitchell
G. Scott
M. Hruszkewycz 1352
Neonatology and Clinical Biochemistry. Anne Green, Imogen Morgen.
1349
Reviewer: Barbara Effects of Cigarette Smoking on Plasma Lipids, Apolipoproteins, and Lipoprotein(a) in Healthy Subjects. Rudiger Siekmeier, Winfried Mdrz,
Hartmut Kronenberger, Seiffert, Werner Gm/i
A
Ulirich B. 1350
M. Goldsmith 1353
THE CLINICAL CHEMIST Compiled
by David E. Bruns
CLINICAL CHEMISTRY, Vol. 40, No. 7, 1994
1354
3A
Volume 40, No. 7(B) July1994
CLCHAU 40(7) 1359-1476 Part 2 of 2 ISSN 0009-9147
llLnfi1llS
Proceedings of the Arnold 0. Beckman/IFCC European Conference on Environmental Toxicology Biomarkers of Chemical Exposure 16-18 June, 1993. Munich,Germany Organizingand EditorialCommittee:Philippe Grandjean (Chairman), Stanley S. Brown, Phil Reavey, and Donald S. Young
Guest Editor: Robert Rej Arnold
0. Beckman
1359
OVERVIEW Biomarkers Phil Reavey,
of Chemical Exposure: Donald S. Young
State
of the Art. Philippe
Grandjean,
Stanley
S. Brown, 1360
ARTICLES Role of Biomarkers Ellen
K Silbergeld,
Critical
Evaluation McLean
Allan
in Identifying and Understanding Devra Lee Davis of Current
Concepts
in Exposure
Environmentally
Induced
Disease.
1363 Assessment.
Birger
G.J. Heinzow, 1368
Technical
and Scientific Developments in Exposure Marker Methodology. Eric J. Sampson, James L. Pirkie, W. Harry Hannon, Dayton T. Miller, Donald G. Patterson, John T. Bernert, David L. Ashley, Robert H. Hill, Elaine W. Gunter, Daniel C. Paschal, Francis W. Spierto, Michael J. Rich
1376
Reference
1385
Larry L. Need ham,
Validity
Limits
in Occupational
of Lead Exposure
Markers
Toxicology.
Antero
in Diagnosis
Aitio
and Surveillance.
Joseph
H. Graziano
Robert
B. Lauwerys,
Cadniiuzn: Exposure Markers as Predictors of Nephrotoxic Alfred M. Bernard, Harry A. Roels, Jean-Pierre Buchet
Effects.
Methylmercury: Significance Pal Weihe, Jesper Bo Nielsen
Exposures.
of Intrauterine
Blood Concentrations of Volatile Organic and in Groups with Suspected Exposure. Joan M. McCraw, Joe V. Wooten 4A
CLINICAL CHEMISTRY, VOL. 40, No. 7, 1994
and Postnatal
1387
1391 Philippe
Grandjean, 1395
Compounds David
in a Nonoccupationally L. Ashley, Michael A. Bonin,
Exposed Frederick
US Population L. Cardinali, 1401
Chlorinated
Dibenzo-p-dioxins
Exposure
to Mixtures
Svensson,
Lillemor
Quality
Mechanisms
Problems
in Analysis
and Congeners
Asplund,
Assurance,
and -furans:
Lars
Accreditation,
of Carcinogenesis
of Polychiorinated Hagmar and Certification:
and Individual
Biphenyls.
Complex
Use in Diagnosis
Adducts: Exposures:
Potentials
Needs
Risks: Experimental
Acceptable
Determining
Skerfving,
and Possibilities. to Cancer.
Susceptibility
Exposure
Schiatter
..
1405
Bengt-Goran
Ren#{233} Dybkaer
Stanley
Venitt
and Disease:
1416 1421
Legal
and Ethical 1426
Peter B. Farmer
and Risk Assessment.
for Assessing
Staffan
Christian
1409
Monitoring the Worker and the Community for Chemical Considerations in the US. Nicholas A. Ash ford Carcinogen
of Biomarkers.
Integrated
Exposures.
and Epidemiological
Masayuki Issues.
1438 Ikeda
Renate
1444
D. Kimbrough
1448
EXTENDED ABSTRACTS Molecular Stephen
Epidemiological
P. Faux,
Mm
Studies in Workers Exposed to Chromium-Containing Gao, T. Ching Aw, Robin A Braithwaite, Leonard S. Levy
Diesel Exhaust-Related Herman Autrup
DNA Adducts
in Garage
Workers.
A Battery of Biomarkers for Detecting Carcinogenic Vigagni, Francesca Maffei, Moreno Paolini, Renata
with Gastrointestinal Hans Opdam Risk from Fungicides. Mesirca, Laura Pozzeti,
Exposure
to Mixed Solvents. Anne Wright
Howard
J. Mason,
Patrizia
Hrelia, Fernanda
Giorgio
Cantelli-Forti
James
and 1462 P. Wheeler,
1,2- and 1,4-Cyclohexanediol. 1466
of Occupational and Environmental Exposures to Benzene by Measuring Acid in Urine. Dankwart Rauscher, Gerhard Lehnert, Jurgen Angerer
trans,trans-Muconic
Serum Total Radical-Trapping Antioxidant Parameter (TRAP) Thim J.J.M. Derhaag, Jan de Jong, Aalt Bast, Paul J.A. Borm Monitoring Occupational Exposure to Some Industrial Adducts. Nico J. van Sittert, Erik W.N. van Vliet
1460
1464
of Exposure to Cyclohexanone, Cyclohexane, and Cyclohexanol: Mr#{225}z, Eva Gdlovd, Hana Nohovd, Dana V(tkovd
Biomomtoring
to Solvents. 1458
in Long-Term Postexposure Investigations of Acetonitrile Exposures in Two Subjects. Dirk Kohlm#{252}ller, Walter Kochen
Hepatic Effects of Chronic Exposure Jaspal S. Purba, Michael D. Wright, Markers Jaroslav
Per Sabro Nielsen,
Air Analyzed
Trichloroethylene
1454
1456
Method to Study Metabolic Interactions in Humans Jesper Baelum, Lars M#{248}lhave,Steen Honor#{233} Hansen,
Exhalation
Compounds.
Chemicals
in Coal Workers.
1468
Roel P. F. Schins, 1470
by Determining
Hemoglobin 1472
CLINICAL CHEMISTRY, Vol. 40, No. 7, 1994
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