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Effect of Abdominal Visceral Fat Change on Regression of Erosive Esophagitis: Prospective Cohort Study
Running title: Regression of Erosive Esophagitis
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Su Youn Nam1 , 2 , Young-Woo Kim3, Bum Joon Park2, Kum Hei Ryu2 , Hyun Boem Kim4
Center for Gastric Cancer, Kyungpook National University Medical Center, Kyungpook
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National University School of Medicine, Daegu, Korea; 2Center for Cancer Prevention & Detection; 3Center for Gastric Cancer; 4Department of Diagnostic Radiology, National Cancer Center, Goyang, Korea
Corresponding author:
Su Youn Nam, M.D., Ph.D.
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Center for Gastric Cancer,
Kyungpook National University Medical Center Kyungpook National University School of Medicine
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807 Hoguk-ro, Buk-gu, Daegu 702-210, Korea Tel: 82-53-200-2610 / Fax: 82-53-200-2028
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E-mail:
[email protected]
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This is a PDF file of an unedited manuscript that has been accepted for publication in Gut and Liver. We are providing the early version of the manuscript as a service to our readers. This manuscript will undergo copyediting, typesetting, and proofreading process which may lead to differences between this version and the final publication form.
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Background/Aims: Although abdominal visceral fat has been associated with erosive esophagitis in
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cross-sectional studies, there are few data on the longitudinal effect. We evaluated the effects of
abdominal visceral fat change on the regression of erosive esophagitis in a prospective cohort study.
Methods: A total of 163 participants with erosive esophagitis at baseline were followed up at 34 months
and underwent esophagogastroduodenoscopy and computed tomography at both baseline and follow-
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up. The longitudinal effects of abdominal visceral fat on the regression of erosive esophagitis were
evaluated using relative risk (RR) and 95% confidence intervals (CIs). Results: Regression was observed in approximately 49% of participants (n=80). The 3rd (RR, 0.13; 95% CI, 0.02 to 0.71) and 4th quartiles (RR, 0.07; 95% CI, 0.01 to 0.38) of visceral fat at follow-up were associated with decreased regression of erosive esophagitis. The highest quartile of visceral fat change reduced the probability of the regression of erosive esophagitis compared to the lowest quartile (RR, 0.10; 95% CI, 0.03 to 0.28). Each trend showed a dose-dependent pattern (p for trend
