Jun 28, 2012 - Effect of artemether on hematological parameters of healthy and uninfected adult Wistar rats. Osonuga IO1,Osonuga OA2, Osonuga A3*, ...
Asian Pac J Trop Biomed 2012; 2(6): 493-495
493
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Asian Pacific Journal of Tropical Biomedicine journal homepage:www.elsevier.com/locate/apjtb
Document heading
doi:10.1016/S2221-1691(12)60083-5
襃
2012
by the Asian Pacific Journal of Tropical Biomedicine. All rights reserved.
Effect of artemether on hematological parameters of healthy and uninfected adult Wistar rats Osonuga IO1,Osonuga OA2, Osonuga A3*, Onadeko AA1, Osonuga AA4 Department of Physiology, Olabisi Onabanjo University, Ikenne Remo, Nigeria Department of Pharmacology, Olabisi Onabanjo University, Ikenne Remo, Nigeria 3 School of Medical Sciences, University of Cape Coast, Ghana 4 Department of Nursing, University of Cape Coast, Ghana 1 2
ARTICLE INFO
ABSTRACT
Article history: Received 10 October 2011 Received in revised form 25 November Accepted 18 December 2011 Available online 28 June 2012
Objective: To evaluate the effect of short term artemether administration on some blood parameters in adult male Wistar rats. Methods: Sixty five albino rats with body weight of 190-220 g were used for the four-phased study. The animals were randomly divided into five groups. The first-four groups of 15 rats were further divided into 3 subgroups of 5 rats. The drug was administered orally at sub-optimal, therapeutic, and high doses of 25, 50 and 75 mg/kg bw, respectively to the rats for 1 day, 2 days and 3 days. Blood samples were collected by cardiopuncture from the rats for hematology at the end of each phase. The last group served as control, and they were given water ad libitum. Results: Artemether caused significant reduction (P
